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Cortactin (CTTN) (NM_138565) Human Recombinant Protein
CAT＃: TP710315
Purified recombinant protein of Human cortactin (CTTN / EMS1), transcript variant 2, full length, with C-terminal DDK tag, expressed in sf9, 20ug
View other "Cortactin" proteins (8)
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CNY 4,020.00
| Cited in 5 publications. |
Product images
Specifications
| Product Data | |
| Species | Human |
| Expression Host | Sf9 |
| Expression cDNA Clone or AA Sequence |
A DNA sequence from TrueORF clone, RC201111, encoding human full-length CTTN
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| Tag | C-DDK |
| Predicted MW | 57.3 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 50 mM Tris-HCl, 100 mM glycine, pH 8.0, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_612632 |
| Locus ID | 2017 |
| UniProt ID | Q14247 |
| Refseq Size | 3208 |
| Cytogenetics | 11q13.3 |
| Refseq ORF | 1539 |
| Synonyms | EMS1 |
| Summary | This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010] |
| Protein Families | Druggable Genome |
| Protein Pathways | Pathogenic Escherichia coli infection, Tight junction |
Citations (5)
| The use of this Proteins has been cited in the following citations: |
|---|
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Anti-Cortactin Autoantibodies Are Associated With Key Clinical Features in Adult Myositis But Are Rarely Present in Juvenile Myositis.
,null,
Arthritis & rheumatology (Hoboken, N.J.)
,PubMed ID 34313394
[CTTN]
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Diagnostic utility of cortactin antibodies in myasthenia gravis.
,null,
Annals of the New York Academy of Sciences
,PubMed ID 29068555
[CTTN]
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Inhibitory cortactin nanobodies delineate the role of NTA- and SH3-domain-specific functions during invadopodium formation and cancer cell invasion.
,null,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
,PubMed ID 28235780
[CTTN]
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Clinical Characteristics of Patients With Double-Seronegative Myasthenia Gravis and Antibodies to Cortactin.
,null,
JAMA neurology
,PubMed ID 27379450
[CTTN]
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Cortactin autoantibodies in myasthenia gravis.
,null,
Autoimmunity reviews
,PubMed ID 25193850
[CTTN]
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Documents
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Resources
| 蛋白相关资源 |
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC403359 | CTTN HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC417430 | CTTN HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LC429248 | CTTN HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY403359 | Transient overexpression lysate of cortactin (CTTN), transcript variant 2 |
CNY 3,080.00 |
|
| LY417430 | Transient overexpression lysate of cortactin (CTTN), transcript variant 1 |
CNY 4,840.00 |
|
| LY429248 | Transient overexpression lysate of cortactin (CTTN), transcript variant 1 |
CNY 3,080.00 |
|
| PH301111 | CTTN MS Standard C13 and N15-labeled recombinant protein (NP_612632) |
CNY 19,520.00 |
|
| TP301111 | Recombinant protein of human cortactin (CTTN), transcript variant 2, 20 µg |
CNY 2,900.00 |
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