STAT6 (NM_003153) Human Recombinant Protein
CAT#: TP720974
Purified recombinant protein of Human signal transducer and activator of transcription 6, interleukin-4 induced (STAT6), transcript variant 2
View other "STAT6" proteins (4)
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CNY 3,140.00
Cited in 1 publication. |
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Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
Ser627-Ser837
|
Tag | C-His |
Predicted MW | 23.9 kDa |
Concentration | lot specific |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
Reference Data | |
RefSeq | NP_003144 |
Locus ID | 6778 |
UniProt ID | P42226 |
Refseq Size | 4031 |
Cytogenetics | 12q13.3 |
Refseq ORF | 2541 |
Synonyms | D12S1644; IL-4-STAT; STAT6B; STAT6C |
Summary | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors |
Protein Pathways | Jak-STAT signaling pathway |
Citations (1)
The use of this Proteins has been cited in the following citations: |
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PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
,null,
Nature Communications
,PubMed ID 27796300
[STAT6]
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC401100 | STAT6 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY401100 | Transient overexpression lysate of signal transducer and activator of transcription 6, interleukin-4 induced (STAT6) |
CNY 3,080.00 |
|
PH310065 | STAT6 MS Standard C13 and N15-labeled recombinant protein (NP_003144) |
CNY 19,520.00 |
|
TP310065 | Recombinant protein of human signal transducer and activator of transcription 6, interleukin-4 induced (STAT6), 20 µg |
CNY 2,900.00 |