IL23 (p19+p40) Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	Sf9
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Human IL-23 consists of two subunits linked via a disulfide bond: P19, the region of Ala21- Pro189) from Accession# NP_057668, and P40, the region of Ile 23-Ser 328) from Accession# NP_002178.2
Tag	Tag Free
Predicted MW	53.3 kDa
Concentration	lot specific
Purity	>95%, as determined by Coomassie stained SDS-PAGE.
Buffer	1 x PBS
Storage	Store at -80°C.
Stability	Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Bioactivity	The ED50 is 0.4 - 2.0 ng/ml, corresponding to a specific activity of 0.5 - 2.50 x 10^6 units/mg determined by mouse splenocyte IL-17A secretion, which is induced by hIL-23 in a dose dependent manner.
Endotoxin	Less than 0.01 ng per µg protein as determined by the LAL method
Reference Data
RefSeq	NP_057668
Locus ID	51561
UniProt ID	Q9NPF7
Refseq Size	1049
Cytogenetics	12q13.3
Refseq ORF	567
Synonyms	IL-23; IL-23A; IL23P19; P19; SGRF
Summary	This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.