IL10 Human Recombinant Protein

CAT#: TP724597

Recombinant Human Interleukin-10/IL-10 (C-His)



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CNY 3,140.00


货期*
5周

规格
    • 10 ug

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Specifications

Product Data
Species Human
Protein Source Human 293
Expression cDNA Clone or AA Sequence
Tag C-6His
Buffer Lyophilized from a 0.2 um filtered solution of PBS, pH 7.2
Note Recombinant Human Interleukin-10 is produced by Human 293 Cells. The target gene encoding Ser19-Asn178 is expressed with a 6His tag at the C terminus.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Locus ID 3586
UniProt ID P22301
Synonyms Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF; IL10; RP11-262N9.1; IL10A;MGC126450; MGC126451; TGIF
Summary Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor (CSIF), is a secreted protein that belongs to the IL-10 family. IL-10 is secreted by various mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. As a major immune regulatory cytokine, IL-10 has profound anti-inflammatory functions on many cells of the immune system, limiting excessive tissue disruption caused by inflammation. Studies showed that IL-10 provides a feedback loop to limit the effector functions of macrophages and DCs on T cells. Once expressed, IL-10 signals through the IL-10 receptor (IL-10R) to activate STAT3. In addition to elevated levels in parasitic infection, high expression levels of IL-10 are also found in retroviral infections inducing immunodeficiency. The immunosuppressive properties of IL-10 suggest a possible clinical use of IL-10 in suppressing rejections of grafts after organ transplantations
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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