S Protein SARS-CoV-2 Recombinant Protein

Specifications

Product Data
Species	SARS-CoV-2
Protein Source	Insect
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) 319-532
Tag	C-8His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant SARS-CoV-2 Spike Protein is produced by Insect. The target gene encoding 319-532 is expressed with a 8His tag at the C terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	43740568
Synonyms	Spike Receptor Binding Domain; Spike RBD
Summary	The SARS-CoV-2 Spike Protein is a glycoprotein expressed in various cell types, which may support its involvement in the innate immune response. Receptors that bind S1 include ACE2, DPP4, and CEACAM. The spike (S) glycoprotein is essential for binding the virus to the host cell during the infection process, as seen in severe acute respiratory syndrome (SARS). In SARS-CoV, the S glycoprotein alone facilitates membrane fusion for virus entry and cell fusion, making it a significant immunogen and entry inhibitor target. Reports show that the 2019-nCoV can infect human respiratory epithelial cells by interacting with the human ACE2 receptor. The spike protein is a type I transmembrane protein containing two subunits: S1 and S2. S1 includes the receptor-binding domain (RBD), which recognizes the cell surface receptor, and S2 includes basic elements needed for membrane fusion. The S protein is crucial in inducing neutralizing-antibody, T-cell responses,and providing protective immunity.

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