Her2 (ERBB2) Human Recombinant Protein

CAT#: TP724631

Recombinant Human ErbB2/Her2(C-His)



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CNY 3,140.00


货期*
5周

规格
    • 10 ug

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经常一起买 (1)
ERBB2 mouse monoclonal antibody, clone OTI4F10 (formerly 4F10)
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Specifications

Product Data
Species Human
Protein Source Human 293
Expression cDNA Clone or AA Sequence
Tag C-6His
Buffer Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note Recombinant human ErbB2 is produced by Human 293 Cells. The target gene encoding T23-T652 is expressed with a 6His tag at the C terminus.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Locus ID 2064
UniProt ID P04626
Synonyms CD340 antigen; CD340; c-erb B2/neu protein; EC 2.7.10; EGFR2; ErbB2; HER2; HER-2; HER2EC 2.7.10.1; herstatin; Metastatic lymph node gene 19 protein; MLN 19; MLN19; Neu Oncogene; NEUHER-2/neu; neuroblastoma/glioblastoma derived oncogene homolog; NGL; NGLTKR1; p185erbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2
Summary ErbB2, also known as human epidermal growth factor receptor 2 (HER2), is a type I membrane glycoprotein that belongs to the epidermal growth factor (EGF) receptor family. ErbB2 is expressed in various tumor tissue including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. ErbB2 plays a key role in development, cell proliferation and differentiation. ErbB2 is reported to be an orphan receptor, with none of the EGF family of ligands able to activate it. Around 30% of breast cancers overexpress ErbB2, which is associated with increased disease recurrence and worse prognosis.
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Adherens junction, Bladder cancer, Calcium signaling pathway, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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