CD22 Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) D20-R687
Tag	C-10His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4
Note	Recombinant Human Siglec-2 is produced by Human 293 Cells. The target gene encoding D20-R687 is expressed with a 10His tag at the C terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	933
UniProt ID	P20273
Synonyms	CD22, SIGLEC2, BL-CAM, SIGLEC-2, Siglec2, SIGLEC2FLJ22814
Summary	B-cell receptor CD22, also known as Siglec-2, is a member of the immunoglobulin superfamily, SIGLEC family of lectins. CD22 is expressed by B-lymphocytes and can mediate B-cell B-cell interactions, as well as the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins, one of which is CD45. As an inhibitory coreceptor of the B-cell receptor (BCR), CD22 plays a central role in establishing signaling thresholds for B-cell activation. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1.
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	B cell receptor signaling pathway, Cell adhesion molecules (CAMs), Hematopoietic cell lineage

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