Cynomolgus Recombinant Protein
CAT#: TP724778
Recombinan Cynomolgus MerTK ECD (C-His)
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CNY 3,140.00
货期*
2周
规格
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Specifications
Product Data | |
Species | Cynomolgus |
Protein Source | Human |
Expression cDNA Clone or AA Sequence |
Arg22-Pro503
|
Tag | C-His |
Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
Note | Recombinant Cynomolgus MerTK ECD (C-His) is produced by Human Cells. The target gene encoding Arg22-Pro503 is expressed with a C-His tag. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | 12 months from date of despatch |
Reference Data | |
Synonyms | MERTK,Mer |
Summary | Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. |
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