Fibronectin (FN1) Human Recombinant Protein
CAT#: TP724801
Biotinylated Recombinant Human Fibronectin ED-B (N-His&Avi)
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CNY 3,140.00
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Specifications
Product Data | |
Species | Human |
Protein Source | E. coli |
Expression cDNA Clone or AA Sequence |
Glu5-Thr95
|
Tag | N-6His&Avi |
Buffer | Supplied as a 0.2 um filtered solution of 50mM Tris, 150mM NaCl, pH7.2. |
Note | Recombinant Human Fibronectin is produced by our E.coli expression system and the target gene encoding Glu5-Thr95 is expressed with a 6His, Avi tag at the N-terminus. |
Storage | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 2335 |
UniProt ID | P02751 |
Synonyms | Fibronectin; FN1 |
Summary | Fibronectin is a glycoprotein of the extracellular matrix that binds integrins. It binds to extracellular matrix components such as collagen, fibrin, and heparan sulfate proteoglycans. Multiple isoforms result from alternative mRNA splicing of the ED-A, ED-B, and III-CS regions, and post-translational modification. Fibronectin is critical for cell adhesion, growth, migration, and differentiation, as well as wound healing and embryonic development. Altered fibronectin expression, degradation, and organization are associated with pathologies, including cancer and fibrosis. Fragmentation of pericellular fibronectin and increased production by peritumoral stroma are early signs of malignant transformation in solid human tumors. Further investigations are encouraged to explore the potential importance of fibronectin production and breakdown during cancer progression. |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein |
Protein Pathways | ECM-receptor interaction, Focal adhesion, Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer |
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