Cynomolgus Recombinant Protein

CAT#: TP724822

Recombinant Cynomolgus B7-1/CD80 (C-His)



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CNY 3,140.00


货期*
5周

规格
    • 10 ug

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Specifications

Product Data
Species Cynomolgus
Protein Source Human 293
Expression cDNA Clone or AA Sequence
Tag C-6His
Buffer Lyophilized from a 0.2 um filtered solution of PBS, 5% Trehalose pH 7.4
Note Recombinant Cynomolgus T-lymphocyte Activation Antigen CD80 is produced by our Mammalian expression system and the target gene encoding Val35-Asn242 is expressed with a 6His tag at the C-terminus.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Synonyms T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7; CD80
Summary CD80, also known as B7-1, is a member of cell surface immunoglobulin superfamily. CD80 is predominately expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. CD80 and CD86, together with their receptors CD28 and CTLA4, form one of the dominant co-stimulatory pathways that mediate T- and B- cell responses. Although both CD28 and CTLA4 can bind to CD80 and CD86, CTLA-4 has 20-100 fold higher affinity than CD28 plays a role in the down-regulation of the immune response. CD80 is also involved in the induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. Therefore, CD80 has the potential to be promising therapeutic targets for autoimmune diseases and various carcinomas.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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