Cynomolgus Recombinant Protein

CAT#: TP725538

Recombinant Cynomolgus GUCY2C (C-hFc)



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CNY 3,140.00


货期*
5周

规格
    • 10 ug

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Specifications

Product Data
Species Cynomolgus
Protein Source Human 293
Expression cDNA Clone or AA Sequence
Tag C-hFc
Buffer Lyophilized from a 0.2 um filtered solution of PBS,pH7.4
Note Recombinant Cynomolgus GUCY2C (C-hFc) is produced by Human Cells. The target gene encoding Ser24-Gln430 is expressed with a C-hFc tag.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Synonyms GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C
Summary GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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