IL17RA Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Leu33-Trp320
Tag	C-His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Note	Recombinant Human Interleukin-17 receptor A is produced by our Mammalian expression system and the target gene encoding Leu33-Trp320 is expressed with a 6His tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	23765
UniProt ID	Q96F46
Synonyms	IL17Rinterleukin-17 receptor A; interleukin 17 receptor A; IL17RA;CD217
Summary	CD217, also known as Interleukin-17 receptor A, is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F, it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6. The signaling events of IL 17 includes activation of NF kappa B and JNK, and require TNF receptor associated factors 6 (TRAF6) in the signaling pathway.
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction

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