BMPR1A Human Recombinant Protein
CAT#: TP727972
Recombinant Human BMP Receptor IA/ALK-3/CD292 (C-Fc-6His)
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CNY 3,140.00
货期*
2周
规格
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经常一起买 (1)
Specifications
Product Data | |
Species | Human |
Protein Source | Human |
Expression cDNA Clone or AA Sequence |
Gln24-Arg152
|
Tag | C-Fc&His |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. |
Note | Recombinant Human Bone Morphogenetic Protein Receptor Type IA/Activin Receptor-like Kinase 3 is produced by our Mammalian expression system and the target gene encoding Gln24-Arg152 is expressed with a Fc, 6His tag at the C-terminus. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 657 |
UniProt ID | P36894 |
Synonyms | Bone Morphogenetic Protein Receptor Type-1A; BMP Type-1A Receptor; BMPR-1A; Activin Receptor-Like Kinase 3; ALK-3; Serine/Threonine-Protein Kinase Receptor R5; SKR5; CD292; BMPR1A; ACVRLK3; ALK3 |
Summary | Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A is a single-pass type I membrane protein and highly expressed in skeletal muscle. BMPR1A contains one GS domain and one protein protein kinase domain. BMPR1A is necessary for the extracellular matrix depostition by osteoblasts. BMPR1A can activate SMAD transcriptional regulators, binding with ligands. Defects in BMPR1A are a cause of juvenile polyposis syndrome, Cowden disease and hereditary mixed polyposis syndrome 2 (HMPS2). |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane |
Protein Pathways | Cytokine-cytokine receptor interaction, TGF-beta signaling pathway |
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