GTP cyclohydrolase 1 (GCH1) (NM_001024024) Human Recombinant Protein
CAT#: TP760518
Purified recombinant protein of Human GTP cyclohydrolase 1 (GCH1), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
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CNY 2,040.00
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding human full-length GCH1
|
Tag | N-His |
Predicted MW | 27.7 kDa |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_001019195 |
Locus ID | 2643 |
UniProt ID | P30793 |
Refseq Size | 1995 |
Cytogenetics | 14q22.2 |
Refseq ORF | 750 |
Synonyms | DYT5; DYT5a; DYT14; GCH; GTP-CH-1; GTPCH1; HPABH4B |
Summary | This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome |
Protein Pathways | Folate biosynthesis, Metabolic pathways |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC400058 | GCH1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LC422611 | GCH1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY400058 | Transient overexpression lysate of GTP cyclohydrolase 1 (GCH1), transcript variant 1 |
CNY 3,080.00 |
|
LY422611 | Transient overexpression lysate of GTP cyclohydrolase 1 (GCH1), transcript variant 2 |
CNY 3,080.00 |
|
TP760308 | Recombinant protein of human GTP cyclohydrolase 1 (GCH1), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug |
CNY 2,040.00 |
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