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Wilms Tumor Protein (WT1) (NM_024424) Human Recombinant Protein
CAT＃: TP760644
Purified recombinant protein of Human Wilms tumor 1 (WT1), transcript variant B, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
View other "Wilms Tumor Protein" proteins (8)
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CNY 2,040.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Species | Human |
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence |
A DNA sequence encoding human full-length WT1
|
| Tag | N-His |
| Predicted MW | 55.8 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_077742 |
| Locus ID | 7490 |
| UniProt ID | P19544 |
| Refseq Size | 3020 |
| Cytogenetics | 11p13 |
| Refseq ORF | 1542 |
| Synonyms | AWT1; GUD; NPHS4; WAGR; WIT-2; WT33 |
| Summary | This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015] |
| Protein Families | Druggable Genome, Transcription Factors |
Citations (2)
| The use of this Proteins has been cited in the following citations: |
|---|
|
The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer
,null,
Journal of Ovarian Research
,PubMed ID 27036110
[WT1]
|
|
Neural precursor cells induce cell death of high-grade astrocytomas via stimulation of TRPV1
,null,
Nature medicine
,PubMed ID 22820645
[WT1]
|
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| 蛋白相关资源 |
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC411289 | WT1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LC424762 | WT1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LC434129 | WT1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY411289 | Transient overexpression lysate of Wilms tumor 1 (WT1), transcript variant C |
CNY 4,840.00 |
|
| LY424762 | Transient overexpression lysate of Wilms tumor 1 (WT1), transcript variant A |
CNY 4,840.00 |
|
| LY434129 | Transient overexpression lysate of Wilms tumor 1 (WT1), transcript variant F |
CNY 3,080.00 |
|
| TP760989 | Purified recombinant protein of Human Wilms tumor 1 (WT1), transcript variant A, full length, with N-terminal HIS tag, expressed in E. coli, 50ug |
CNY 2,040.00 |
|
| TP762366 | Purified recombinant protein of Human Wilms tumor 1 (WT1), transcript variant B, Met1-Ala78-GGGGS-Lys141-Gly229, with N-terminal His tag, expressed in E.coli, 50ug |
CNY 1,950.00 |
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