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Macrophage Scavenger Receptor I (MSR1) (NM_138715) Human Recombinant Protein
CAT＃: TP761290
Purified recombinant protein of Human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AI, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
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CNY 2,040.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Species | Human |
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence |
A DNA sequence encoding human full-length MSR1
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| Tag | N-GST and C-His |
| Predicted MW | 75.6 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_619729 |
| Locus ID | 4481 |
| UniProt ID | P21757 |
| Refseq Size | 3761 |
| Cytogenetics | 8p22 |
| Refseq ORF | 1353 |
| Synonyms | CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI; SR-AII; SR-AIII; SRA |
| Summary | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] |
| Protein Families | Druggable Genome, Transmembrane |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC403366 | MSR1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC408527 | MSR1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC419319 | MSR1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY403366 | Transient overexpression lysate of macrophage scavenger receptor 1 (MSR1), transcript variant SR-AI |
CNY 3,080.00 |
|
| LY408527 | Transient overexpression lysate of macrophage scavenger receptor 1 (MSR1), transcript variant SR-AIII |
CNY 3,080.00 |
|
| LY419319 | Transient overexpression lysate of macrophage scavenger receptor 1 (MSR1), transcript variant SR-AII |
CNY 3,080.00 |
|
| PH312931 | MSR1 MS Standard C13 and N15-labeled recombinant protein (NP_002436) |
CNY 19,520.00 |
|
| PH323314 | MSR1 MS Standard C13 and N15-labeled recombinant protein (NP_619730) |
CNY 19,520.00 |
|
| TP312931 | Recombinant protein of human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AII, 20 µg |
CNY 2,900.00 |
|
| TP323314 | Recombinant protein of human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AIII, 20 µg |
CNY 2,900.00 |
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