P2RX7 Human siRNA Oligo Duplex (Locus ID 5027)
CAT#: SR321204
P2RX7 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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SR321204 is the updated version of SR303325.
CNY 4,090.00
货期*
7周
规格
Cited in 1 publication. |
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_002562, NM_177427, NR_033948, NR_033949, NR_033950, NR_033951, NR_033952, NR_033953, NR_033954, NR_033955, NR_033956 |
Synonyms | P2X7 |
Components | P2RX7 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 5027)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
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ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival
,Gilbert, SM;Oliphant, CJ;Hassan, S;Peille, AL;Bronsert, P;Falzoni, S;Di Virgilio, F;McNulty, S;Lara, R;,
Oncogene
,PubMed ID 30087439
[P2RX7]
|
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