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Atoh8 (NM_153778) Mouse Untagged Clone
CAT＃: MC204248
Atoh8 (untagged) - Mouse atonal homolog 8 (Drosophila) (Atoh8), (10ug)
CNY 2,400.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 4933425C05Rik; bHLHa21; Hath6; Math6; okadin |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC023684
CCACGCGTCCGCCCACGCGTCCGCCCACGCGTCCGGCGCGTCCCGGGCAGTCCCACGCCCCAGCCTCACG CCGTCCTCGCCATGAAGCACATCCCGGTCCTCGAGGACGGGCCGTGGAAGACTGTGTGCGTTAAAGAACT GAACGGCCTCAAGAAGCTCAAGCGGAAAGGCAAGGAGCCGGTGCGGCGCGCGAATGGCTATAAAACTTTC CGATTGGACTTGGAAGCTCCCGAGCTCGGCGCCACAGTCAGCACCACCGCCGCCACCAACGGGCTTCGGG ACAGGACACAACCGTTCCCGATCGCGACCCCAGTACCAGCCTCAGTGGCGCCGGCGGTTCCTCCAGGTGG AGGCACAGACACAGCCAGGGAATTCCGGGGCATCAGAGCGCCTGAGGTCTCTGACGCGCGCAAACGCGGT TTCGCTCTGGGCACAGTGGGACCGGGACTACCCACGCCACCGCCGCCTCCCGCATCTCAGAGCTTGGCAC CCGGGGATCCCGAGGCGCACTCCTTCCGCGAGCAGGCTCTGCGTCCCCGCATCTTGCTGTGCGCCCCTCC CGCGCGTCCCACACAATCCGCGCCTCTCGCACCCCCAGCGGCGCCACAAGAGTCCCCCGTGCGCCCTGCG CCCCCCACGCGCCCGGGGGAAAGTTCCTACTCGTCAATTTCACACGTAATTTACAATAACCACCCGGATT CTTCCGCGTCGCCTAGGAAACGGCCAGGCGAAGCGACCGCCGCCTCAACGGAGATCAAAGCCCTGCAGCA GACCCGGAGGCTTCTGGCCAACGCCAGGGAGCGGACGCGGGTGCACACCATCAGCGCAGCCTTCGAGGCG CTGAGGAAGCAGGTGCCGTGCTACTCCTATGGGCAGAAGCTCTCCAAACTGGCCATCCTGAGGATTGCCT GTAACTACATCTTGTCCCTGGCACGGCTGGCTGACCTGGACTACAGTGCCGACCACAGCAACCTCAGCTT CTCCGAGTGTGTGCAGCGCTGCACCCGCACCCTGCAGGCAGAAGGGCGAGCCAAGAAACGGAAGGAGTGA CCTGCCACAGGCTAGACCACAGACACCACTGTGAGTCTCTTCCCAGTTGGGACTGAGGAGAAAGCTGGGA CCACCAGGAGACGACCAGCCTCATTCCTTGTCTTCCTCAAGATGCTGCCAGATACTCAGCCCGTGTACCA TCTCTCAGGGTCACTTAGAACCAGCACAAGGGCCGCCGGCCTCCCTCTCCGTCTCCTGCCATCCAGGGTT ACTTCAGATTTTGCCTTCTGCCTGGTGGGGCGGGCTATTGCCAAAGATTCTACAGAGATCGTCCAAGGAA ATTATGGATGAGGCCCCAACAGCACAAAACCACATCATTGCTGCCCTACCAAGTCCACCTCAAGCCAAAG ATGGATTAGCACTACTGCTAGGAACCCATGCAGTGGGCACCTGGTGACCATCAGAAGCACTTAACCCTCC AAGCCAGTGCTCGCTCTGTGCTGGGCCCTGAGCAGCTGGTTGTCTTCGAGACAAGCTTCCTAGAGCCACG ACAAGCAGGCTGCTGGTGGAAGGTGGAGCCCGAGATCCTTGGCCCTTCCCATTAGCTACCCAGACCTCTG ACTCCTGTTCCCGATACTCTTTGGGTCCTGGCTCCTTCTTGGACCCCAAGCCTCCTGAGAGAGGAGGGAA GGGGGAGACTAAAGAAGCAATATTGCCCCATACCCCACCCGGGATGTGCCCCAAGGAAATCTTTCTGACA GTCCTTGCTCCCAGCCCCTGCCCCAGCAGGTGCGCCTCACCAGTGGTCAGGTTCAGGCTAACACTTAAAT TAGCACTCTGCTGGAGAGCAGCTGCCTGTGGACAGGCCAGGCAGGAGGACTTAGGGAGGAAGGGACCAGG GGAATGGGCCAGGATGTGGGGGAAGGGGCACGTTCAAAGCCAAGGCCTGCTCCTTGTGCTCCAGAGGCCA AAGCTGTTCACATCTGTGTGCAACCATCTGCTTCAAATTGAAGTAAAAGCGGCAACATATAAAAAAAAAA AAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_153778 |
| Insert Size | 969 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | BC023684, AAH23684 |
| RefSeq Size | 2035 bp |
| RefSeq ORF | 969 bp |
| Locus ID | 71093 |
| UniProt ID | Q99NA2 |
| Gene Summary | Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). Regulates endothelial cell proliferation, migration and tube-like structures formation (By similarity). Modulates endothelial cell differentiation through NOS3 (By similarity). May be implicated in specification and differentiation of neuronal cell lineages in the brain (PubMed:11733035). May participate in kidney development and may be involved in podocyte differentiation (PubMed:16937370). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (PubMed:18560595). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (PubMed:24186058). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (By similarity). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (PubMed:23938248).[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG204653 | Atoh8 (tGFP-tagged) - Mouse atonal homolog 8 (Drosophila) (Atoh8) |
CNY 2,850.00 |
|
| MR204653 | Atoh8 (Myc-DDK-tagged) - Mouse atonal homolog 8 (Drosophila) (Atoh8) |
CNY 2,400.00 |
|
| MR204653L3 | Lenti ORF clone of Atoh8 (Myc-DDK-tagged) - Mouse atonal homolog 8 (Drosophila) (Atoh8) |
CNY 4,750.00 |
|
| MR204653L4 | Lenti ORF clone of Atoh8 (mGFP-tagged) - Mouse atonal homolog 8 (Drosophila) (Atoh8) |
CNY 4,800.00 |
