United States
Germany
Japan
United Kingdom
China
shRNA Citations
OriGene产品已被全世界的科学家广泛使用，以提高他们的研究效率。 为了供您参考，我们收集了一些使用OriGene产品发表过的代表性的引用文献，将其发布在此页面上。
使用基因名称或靶标名称搜索文献
这是研究人员使用OriGene产品后最新发表的一些论文。
| 靶点 | 研究论文 | 杂志 | 产品类型 | 货号 |
|---|---|---|---|---|
| THOC2 expression and its impact on 5-fluoro resistance in glioblastoma multiforme | American Journal of Cancer Research | shRNA | TR30021 | |
| A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial-mesenchymal transition | International Journal of Oncology | shRNA | TR30021 | |
| An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma | Nature Communications | shRNA | TR30021 | |
| A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling | The EMBO Journal | shRNA | TR30015 | |
| Targeting the secreted RGDKGE collagen fragment reduces PD‑L1 by a proteasome‑dependent mechanism and inhibits tumor growth. | Oncology reports | shRNA | TR30021 | |
| In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma | Nature Communications | shRNA | TR30012 | |
| Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform. | Biochemical and biophysical research communications | shRNA | TR30015 | |
| Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin | International Journal of Oncology | shRNA | TR30021 | |
| A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration | Developmental cell | shRNA | TR30021 | |
| Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy. | Journal of advanced research | shRNA | TR30021 | |
| Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia | JCI Insight | shRNA | TR30021 | |
| Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer | Scientific Reports | shRNA | TR30021 | |
| Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity | Journal for Immunotherapy of Cancer | shRNA | TR30021 | |
| The TLK1–MK5 Axis Regulates Motility, Invasion, and Metastasis of Prostate Cancer Cells | Cancers | shRNA | TR30021 | |
| The STIM1/2-Regulated Calcium Homeostasis Is Impaired in Hippocampal Neurons of the 5xFAD Mouse Model of Alzheimer’s Disease | International Journal of Molecular Sciences | shRNA | TR30021 | |
| Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals. | PLoS biology | shRNA | TR30012 | |
| Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals. | PLoS biology | shRNA | TR30013 | |
| BAG3 Attenuates Ischemia-Induced Skeletal Muscle Necroptosis in Diabetic Experimental Peripheral Artery Disease | International Journal of Molecular Sciences | shRNA | TR30013 | |
| DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting | Cell reports | shRNA | TR30021 | |
| The role of FYCO1-dependent autophagy in lens fiber cell differentiation. | Autophagy | shRNA | TR30021 | |
| Cadherin‐3 is a novel oncogenic biomarker with prognostic value in glioblastoma | Molecular Oncology | shRNA | TR30021 | |
| The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus | eLife | shRNA | TR30021 | |
| Matrix Metalloproteinase-1 (MMP1) Upregulation through Promoter Hypomethylation Enhances Tamoxifen Resistance in Breast Cancer | Cancers | shRNA | TR30021 | |
| Guidelines for the Detection of NADPH Oxidases by Immunoblot and RT-qPCR | Methods in molecular biology (Clifton, N.J.) | shRNA | TR30013 | |
| Attenuation of MAMLD1 Expression Suppresses the Growth and Migratory Properties of Gonadotroph Pituitary Adenomas. | Pathology oncology research : POR | shRNA | TR30021 | |
| Usp9X Controls Ankyrin-repeat Domain Protein Homeostasis during Dendritic Spine Development | Neuron | shRNA | TR30015 | |
| The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo | The Journal of Physiology | shRNA | TR30021 | |
| Molecular Motor KIF3B Acts as a Key Regulator of Dendritic Architecture in Cortical Neurons | Frontiers in Cellular Neuroscience | shRNA | TR30021 | |
| Intratumoral IFN-α gene delivery reduces tumor-infiltrating regulatory T cells through the downregulation of tumor CCL17 expression. | Cancer gene therapy | shRNA | TR30003 | |
| Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD + Recycling | Cell metabolism | shRNA | TR30012 | |
| Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain | The Journal of Cell Biology | shRNA | TR30012 | |
| Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation. | Cell reports | shRNA | TR30003 | |
| Regulation of estrogen signaling and breast cancer proliferation by an ubiquitin ligase TRIM56 | Oncogenesis | shRNA | TR30013 | |
| Oncogenic transgelin-2 is differentially regulated in isocitrate dehydrogenase wild-type vs. mutant gliomas | Oncotarget | shRNA | TR30012 | |
| Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single Step Transformation by KRAS Mutations | Cancer cell | shRNA | TR30012 | |
| Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma. | Biology of the cell | shRNA | TR30021 | |
| Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. | Science (New York, N.Y.) | shRNA | TR30021 | |
| Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery | eLife | shRNA | TR30012 | |
| The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer. | Biochemical and biophysical research communications | shRNA | TR30021 | |
| A large-scale RNAi screen identifies LCMR1 as a critical regulator of Tspan8-mediated melanoma invasion. | Oncogene | shRNA | TR30012 | |
| Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle | PLoS ONE | shRNA | TR30013 | |
| Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle | PLoS ONE | shRNA | TR30007 | |
| Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway. | The American journal of pathology | shRNA | TR30003 | |
| Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype | Nat. Immunol. | shRNA | TR30012 | |
| Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer | Clin. Cancer Res. | shRNA | TR30015 | |
| Displacement correlations between a single mesenchymal-like cell and its nucleus effectively link subcellular activities and motility in cell migration analysis | Sci Rep | shRNA | TR30015 | |
| Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease | Mol. Psychiatry | shRNA | TR30021 | |
| Platelet integrin a6ß1 controls lung metastasis through direct binding to cancer cell-derived ADAM9 | JCI Insight | shRNA | TR30021 | |
| Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-ß autocrine loop | Oncotarget | shRNA | TR30021 | |
| Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice | Gastroenterology | shRNA | TR30007 | |
| Identification of NEK3 Threonine 165 as a Novel Regulatory Phosphorylation Site that Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration | J. Biol. Chem. | shRNA | TR30014 | |
| Identification of NEK3 Threonine 165 as a Novel Regulatory Phosphorylation Site that Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration | J. Biol. Chem. | shRNA | TR30015 | |
| Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential | Horm Cancer | shRNA | TR30008 | |
| IMP2 axonal localization, RNA interactome, and function in the development of axon trajectories | Development | shRNA | TR30012 | |
| Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis | Nat Commun | shRNA | TR30012 | |
| Nm23H1 mediates tumor invasion in esophageal squamous cell carcinoma by regulation of CLDN1 through the AKT signaling | Oncogenesis | shRNA | TR20003 | |
| High Podocalyxin levels promote cell viability partially through up-regulation of Annexin A2 | Biochem. Biophys. Res. Commun. | shRNA | TR30013 | |
| Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1 | J. Virol. | shRNA | TR30021 | |
| Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells | Cancer Cell | shRNA | TR30021 | |
| Folate Receptor Alpha Upregulates Oct4, Sox2 and Klf4 and Downregulates miR-138 and miR-let-7 in Cranial Neural Crest Cells | Stem Cells | shRNA | TR30013 | |
| SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair | EMBO J. | shRNA | TR30003 | |
| SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair | EMBO J. | shRNA | TR30012 | |
| Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma | Oncogene | shRNA | TR30012 | |
| Characterization of SKAP/Kinastrin isoforms - The N-terminus defines tissue specificity and Pontin binding | Hum. Mol. Genet. | shRNA | TR30021 | |
| Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death | Sci Rep | shRNA | TR30013 | |
| Upregulation of long noncoding RNA LOC100507661 promotes tumor aggressiveness in thyroid cancer | Mol. Cell. Endocrinol. | shRNA | Custom shRNA for ncRNA | |
| Molecular Mechanisms of Malignant Transformation by Low Dose Cadmium in Normal Human Bronchial Epithelial Cells | PLoS ONE | shRNA | TR30013 | |
| HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells | Mol Med Rep | shRNA | TR30013 | |
| OCT-4: a novel estrogen receptor-a collaborator that promotes tamoxifen resistance in breast cancer cells | Oncogene | shRNA | TR30021 | |
| FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1 | Nature Communications | shRNA | TR30021 | |
| Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration | Free Radic. Biol. Med. | shRNA | TR20003 | |
| Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration | Free Radic. Biol. Med. | shRNA | TR30003 | |
| Regulación del Uniportador de Calcio Mitocondrial por MICU1 y MICU2 | thesis | shRNA | TR30014 | |
| Inhibition of the Expression of the Small Heat Shock Protein aB-crystallin Inhibits Exosome Secretion in Human Retinal Pigment Epithelial Cells in Culture | J. Biol. Chem. | shRNA | TR30007 | |
| CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor | Oncogene | shRNA | TR30013 | |
| Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heart | Aging (Albany NY) | shRNA | TR30023 | |
| aCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome | Nucleic Acids Res. | shRNA | TR30007 | |
| Development of a novel HAC-based gain of signal quantitative assay for measuring chromosome instability (CIN) in cancer cells | Oncotarget | shRNA | TR30007 | |
| Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone | Neurobiol. Dis. | shRNA | TR20003 | |
| NF-YA splice variants have different roles on muscle differentiation | Biochim. Biophys. Acta | shRNA | TR30021 | |
| IMP1 suppresses breast tumor growth and metastasis through the regulation of its target mRNAs | Oncotarget | shRNA | TR30007 | |
| MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo. | Cancer letters | shRNA | TR30013 | |
| A Conserved Function in Phosphatidylinositol Metabolism for Mammalian Vps13 Family Proteins | PLoS ONE | shRNA | TR30015 | |
| Der Einfluss des Mismatch Reparaturfaktors hMSH2 auf distinkte Reparaturwege der DNA Doppelstrangbruch Reparatur | thesis | shRNA | TR30012 | |
| Synergistic restoring effects of isoproterenol and magnesium on KCNQ1-inhibited bradycardia cell models cultured in microelectrode array. | Cardiology | shRNA | TR30013 | |
| KIF20A-Mediated RNA Granule Transport System Promotes the Invasiveness of Pancreatic Cancer Cells | Neoplasia (New York, N.Y.) | shRNA | TR30013 | |
| VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2–dependent Ca 2+ signaling | Proceedings of the National Academy of Sciences of the United States of America | shRNA | TR30012 | |
| The Transcription Factor GLI1 Interacts with SMAD Proteins to Modulate Transforming Growth Factor β-Induced Gene Expression in a p300/CREB-binding Protein-associated Factor (PCAF)-dependent Manner | The Journal of Biological Chemistry | shRNA | TR30013 | |
| Autophagic Clearance of Mitochondria in the Kidney Copes with Metabolic Acidosis | Journal of the American Society of Nephrology : JASN | shRNA | TR30012 | |
| Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3σ. | Journal of cell science | shRNA | TR30013 | |
| APLP2 regulates neuronal stem cell differentiation during cortical development. | Journal of cell science | shRNA | TR30012 | |
| miR-126&126* Restored Expressions Play a Tumor Suppressor Role by Directly Regulating ADAM9 and MMP7 in Melanoma | PLoS ONE | shRNA | TR30013 | |
| Phox activity of differentiated PLB-985 cells is enhanced, in an agonist specific manner, by the PLA2 activity of Prdx6-PLA2. | European journal of immunology | shRNA | TR30003 | |
| Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation | Carcinogenesis | shRNA | TR30003 | |
| Estrogenic transmembrane receptor of GPR30 mediates invasion and carcinogenesis by endometrial cancer cell line RL95-2. | Journal of cancer research and clinical oncology | shRNA | TR30003 | |
| Selenoprotein W depletion induces a p53- and p21-dependent delay in cell cycle progression in RWPE-1 prostate epithelial cells. | Journal of cellular biochemistry | shRNA | TR30012 | |
| B7-H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis-associated genes. | International journal of cancer | shRNA | TR30003 | |
| Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. | Oncogene | shRNA | TR30003 | |
| The G protein-coupled receptor GPR30 mediates the proliferative and invasive effects induced by hydroxytamoxifen in endometrial cancer cells. | Biochemical and biophysical research communications | shRNA | TR30003 | |
| The bone morphogenetic protein antagonist Gremlin is overexpressed in human malignant mesothelioma. | Oncology reports | shRNA | TR30012 | |
| Phosphorylation of microtubule-associated protein tau by AMPK-related kinases. | Journal of neurochemistry | shRNA | TR30013 | |
| Endogenous hydrogen sulfide is involved in asymmetric dimethylarginine-induced protection against neurotoxicity of 1-methyl-4-phenyl-pyridinium ion. | Neurochemical research | shRNA | TR30012 | |
| Proteomic analysis of testis biopsies in men treated with transient scrotal hyperthermia reveals the potential targets for contraceptive development. | Proteomics | shRNA | TR30003 | |
| Indole-3-Carbinol Triggers Aryl Hydrocarbon Receptor-dependent Estrogen Receptor (ER)α Protein Degradation in Breast Cancer Cells Disrupting an ERα-GATA3 Transcriptional Cross-Regulatory Loop | Molecular Biology of the Cell | shRNA | TR30003 | |
| Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components | Proceedings of the National Academy of Sciences of the United States of America | shRNA | TR30003 | |
| Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ERK mitogen-activated protein kinase pathway. | Cancer science | shRNA | TR30003 | |
| Telomerase reverse transcriptase regulates the expression of a key cell cycle regulator, cyclin D1. | Biochemical and biophysical research communications | shRNA | TR30003 | |
| ABCB1 | Targeted co-delivery of paclitaxel and anti P-gp shRNA by low molecular weight PEI decorated with L-3,4-dihydroxyphenylalanine. | Biotechnology progress | shRNA | TF315032 |
| ABCB1 | Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells | Cancer Lett. | shRNA | TF315032 |
| ABCC4 | Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer | Oncotarget | shRNA | TR315025 |
| ABCC6 | Dysregulation of gene expression in ABCC6 knockdown HepG2 cells | Cell. Mol. Biol. Lett. | shRNA | TR315023 |
| ABCG2 | Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2 | Exp. Mol. Med. | shRNA | TR315016 |
| Abhd6 | Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation | J. Biol. Chem. Dec 2013. | shRNA | TG306904 |
| ABI1 | PTEN dephosphorylates Abi1 to promote epithelial morphogenesis | J. Cell Biol. | shRNA | TG513768 |
| Abi1 | PTEN dephosphorylates Abi1 to promote epithelial morphogenesis | The Journal of Cell Biology | shRNA | TL513768 |
| ABI1 | PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1 | Sci Rep | shRNA | TF315014 |
| ABI2 | PTEN dephosphorylates Abi1 to promote epithelial morphogenesis | J. Cell Biol. | shRNA | TF508429 |
| Abi2 | PTEN dephosphorylates Abi1 to promote epithelial morphogenesis | The Journal of Cell Biology | shRNA | TL508429 |
| ACKR2 | A novel ACKR2-dependent role of fibroblast-derived CXCL14 in epithelial-to-mesenchymal transition and metastasis of breast cancer | Clin. Cancer Res. | shRNA | TF503412 |
| ACKR3 | CXCR7 maintains osteosarcoma invasion after CXCR4 suppression in bone marrow microenvironment | Tumour Biol. | shRNA | TR305345 |
| ACKR3 | The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation | Mol. Cancer | shRNA | TR305345 |
| ACKR3 | Use of shRNA for Stable Suppression of Chemokine Receptor Expression and Function in Human Cancer Cell Lines | Methods Mol. Biol. | shRNA | TG305345 |
| ACLY | ATP-Citrate Lyase Reduction Mediates Palmitate-induced Apoptosis in Pancreatic Beta Cells | J. Biol. Chem., Oct 2010; 285: 32606 - 32615 | shRNA | TR505684 |
| ACP5 | ACP5, a direct transcriptional target of FoxM1, promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma | Oncogene doi:10.1038/onc.2013.90 | shRNA | TG314985 |
| ACTN4 | Alpha-actinin-4 is Required for Amoeboid-type Invasiveness of Melanoma Cells | J. Biol. Chem. | shRNA | TG314967 |
| ACVRL1 | The role of Alk-1 and Alk-5 in the mechanosensing of chondrocytes | Cell. Mol. Biol. Lett. | shRNA | TG710699 |
| ADAM12 | A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial-mesenchymal transition | International Journal of Oncology | shRNA | TL306850 |
| ADAM8 | ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP-9 expression and transendothelial migration in breast cancer cells | Int. J. Cancer | shRNA | TF314948 |
| ADAM8 | ADAM8 as a drug target in pancreatic cancer | Nat Commun | shRNA | TF314948 |
| Adamts12 | Identification of relevant genetic alterations in cancer using topological data analysis | Nature Communications | shRNA | TL510190 |
| ADAMTS15 | Genetic Inactivation of ADAMTS15 Metalloprotease in Human Colorectal Cancer | Cancer Res., Jun 2009; 69: 4926 - 4934 | shRNA | TR306839 |
| ADAR | ADAR1 restricts LINE-1 retrotransposition | Nucleic Acids Res. | shRNA | TG306828 |
| ADAR | Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma | Nature Medicine 19, 209-216 doi:10.1038/nm.3043 | shRNA | TG306828 |
| Adcy5 | Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation | J. Cell Sci., Jan 2012; 125: 176 - 188. | shRNA | TG506651 |
| Adcyap1 | Age-Related Decline of Autocrine Pituitary Adenylate Cyclase-Activating Polypeptide Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells | J. Gerontol. A Biol. Sci. Med. Sci. | shRNA | TR709809 |
| ADIPOR1 | Underactivation of the adiponectin-adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression | Clin Exp Metastasis. 2013 Oct 5 | shRNA | TG306815 |
| ADM2 | Adrenomedullin2 (ADM2)/Intermedin (IMD): A potential role in the pathophysiology of Preeclampsia | J. Clin. Endocrinol. Metab. | shRNA | TR306813 |
| ADORA2A | Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy | J. Clin. Invest. | shRNA | TF314920 |
| ADPRH | Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair | JCI Insight | shRNA | TG512261 |
| ADRB2 | Housing temperature-induced stress drives therapeutic resistance in murine tumour models through ß2-adrenergic receptor activation | Nat Commun | shRNA | TG314911 |
| ADRM1 | Regulation of NF-{kappa}B activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13) | PNAS, Aug 2010; 107: 13854 - 13859 | shRNA | TR306807 |
| AGBL3 | Structural modeling and functional characterization of mammalian cytosolic carboxypeptidases 2 and 3 | Thesis | shRNA | TG318365 |
| Ager | RAGE ablation attenuates glioma progression and enhances tumor immune responses by suppressing galectin-3 expression. | Neuro-oncology | shRNA | TL515756 |
| AGXT | In Silico Modeling of Liver Metabolism in a Human Disease Reveals a Key Enzyme for Histidine and Histamine Homeostasis | Cell Rep | shRNA | TR314885 |
| Ahnak | Neurite outgrowth induced by NGF or L1CAM via activation of the TrkA receptor is sustained also by the exocytosis of enlargeosomes | Proc. Natl. Acad. Sci. U.S.A. | shRNA | TR514924 |
| Ahnak2 | AHNAK2 Participates in the Stress-Induced Nonclassical FGF1 Secretion Pathway | J. Cell. Biochem. | shRNA | TG512658 |
| AHR | The aryl hydrocarbon receptor is a novel negative regulator of interleukin-17-mediated signaling and inflammation in vitro | FEBS Lett. | shRNA | TG320259 |
| AHR | Interleukin-24 as a target cytokine of environmental aryl hydrocarbon receptor agonist exposure in the lung | Toxicol. Appl. Pharmacol | shRNA | TR320259 |
| AHR | Indole-3-Carbinol Triggers Aryl Hydrocarbon Receptor-dependent Estrogen Receptor (ER){alpha} Protein Degradation in Breast Cancer Cells Disrupting an ER{alpha}-GATA3 Transcriptional Cross-Regulatory Loop | Mol. Biol. Cell, Apr 2010; 21: 1166 - 1177 | shRNA | TR320259 |
| AHRR | Wood Smoke Enhances Cigarette Smoke-Induced Inflammation by Inducing the Aryl Hydrocarbon Receptor Repressor in Airway Epithelial Cells | Am. J. Respir. Cell Mol. Biol. | shRNA | TR306787 |
| AIFM1 | Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression | Blood, Mar 2011; 117: 2891 - 2900 | shRNA | TR302572 |
| AIM2 | Francisella tularensis Reveals a Disparity between Human and Mouse NLRP3 Inflammasome Activation | J. Biol. Chem., Nov 2011; 286: 39033 - 39042. | shRNA | TR314876 |
| AKIRIN2 | A critical role for the nuclear protein Akirin2 in the formation of mammalian muscle in vivo | Genesis | shRNA | TF805514 |
| AKT1 | Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells | Br. J. Cancer | shRNA | TR320260 |
| Alas1 | Heterochromatin protein (HP)1γ is not only in the nucleus but also in the cytoplasm interacting with actin in both cell compartments | Biochim. Biophys. Acta | shRNA | TG500071 |
| ALDH1B1 | Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma | Pancreas | shRNA | TF314844 |
| ALDH1B1 | ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/ß-Catenin, Notch and PI3K/Akt Signaling Pathways | PLoS ONE | shRNA | TF314844 |
| ALKBH3 | Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells | Biochim Biophys Acta Gene Regul Mech | shRNA | TR306757 |
| ALOX12 | Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection | Proc. Natl. Acad. Sci. U.S.A. | shRNA | TR314824 |
| ALOX15 | Mechanistic Contribution of Ubiquitous 15-Lipoxygenase-1 Expression Loss in Cancer Cells to Terminal Cell Differentiation Evasion | Cancer Prevention Research, Dec 2011; 4: 1961 - 1972. | shRNA | TR314822 |
| AMER1 | Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression | Nat Commun | shRNA | TG307603 |
| AMPH | AMPH-1 is a tumor suppressor of lung cancer by inhibiting Ras-Raf-MEK-ERK signal pathway | Lasers Med Sci | shRNA | TR306724 |
| ANG2 | Angiopoietin-2 Regulates Cortical Neurogenesis in the Developing Telencephalon | Cereb Cortex, Jul 2011; 21: 1695 - 1702. | shRNA | TR500092 |
| ANGPT1 | Oct4-dependent FoxC1 Activation Improves the Survival and Neovascularization of Mesenchymal Stem Cells under Myocardial Ischemia | Research Square | shRNA | TR711949 |
| Angpt2 | Angiopoietin-2 Regulates Cortical Neurogenesis in the Developing Telencephalon | Cereb Cortex, Dec 2010; 10.1093/cercor/bhq243 | shRNA | TR514004 |
| Angptl4 | Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines. | Oncology reports | shRNA | TL713738 |
| ANK | Antagonistic interactions between osterix and pyrophosphate during cementum formation | Bone | shRNA | TR500093 |
| ANO5 | Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca2+ signaling of differentiated C2C12 myotubes | Korean J. Physiol. Pharmacol. | shRNA | TG509067 |
| Ano6 | Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine | Cell Host Microbe | shRNA | TF511035 |
| Ano6 | Calcium-dependent phospholipid scrambling by TMEM16F | Nature 468, 834-838 (24 November 2010) doi:10.1038/nature09583 Letter | shRNA | TR511035 |
| ANXA1 | The Effect of Annexin A1 as a Potential New Therapeutic Target on Neuronal Damage by Activated Microglia | Molecules and cells | shRNA | TG513843 |
| ANXA1 | Hydrodynamic stress stimulates growth of cell clusters via the ANXA1/PI3K/AKT axis in colorectal cancer | Sci Rep | shRNA | TR314775 |
| ANXA1 | Differential expression of ANXA1 in benign human gastrointestinal tissues and cancers | BMC Cancer July 2014 | shRNA | TR314775 |
| Anxa2 | Annexin A2 Enhances Complement Activation by Inhibiting Factor H | J. Immunol. | shRNA | TF500250 |
| ANXA2 | Annexin A2 is a C-terminal PCSK9 binding protein that regulates endogenous LDL receptor levels | J. Biol. Chem., Sep 2008; 10.1074/jbc.M805971200. | shRNA | TR314772 |
| ANXA2R | The Annexin a2 Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog Pathway | PLoS ONE | shRNA | TG315286 |
| ANXA6 | Balancing functions of annexin A6 maintain equilibrium between hypertrophy and apoptosis in cardiomyocytes | Cell Death Dis | shRNA | TG314768 |
| ANXA6 | Cytosolic dynamics of annexin A6 triggers feedback regulation of hypertrophy via atrial natriuretic peptide in cardiomyocytes | J. Biol. Chem., Jan 2014. | shRNA | TG314768 |
| AP2A1 | Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation | J. Biol. Chem., Mar 2012; 287: 9429 - 9440. | shRNA | TR314754 |
| AP2M1 | Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2 | J. Biol. Chem. | shRNA | TG712191 |
| AP2M1 | Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2 | BioRxiv | shRNA | TG712191 |
| APBB1 | A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer\'s disease pathologies | Brain : a journal of neurology | shRNA | TG306652 |
| APBB1 | Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation | Sci Rep | shRNA | TG306652 |
| APCS | Complex formation with Pentraxin-2 regulates Factor X plasma levels and macrophage interactions | Blood | shRNA | TR501968 |
| APOBEC3 | Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy | Nature communications | shRNA | TG505334 |
| APOBEC3 | APOBEC3 mediates resistance to oncolytic viral therapy | Molecular Therapy - Oncolytics | shRNA | TR505334 |
| APOE | Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity | Front Immunol | shRNA | TG500118 |
| APOE | Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase C | J. Biol. Chem., May 2012; 287: 15947 - 15958. | shRNA | TR314721 |
| APRT | Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells | PLoS ONE | shRNA | TG320095 |
| Aqp1 | Aquaporin 1 is Important for Maintaining Secretory Granule Biogenesis in Endocrine Cells | Mol. Endocrinol., Aug 2008; 22: 1924 - 1934 | shRNA | TR500121 |
| AQP3 | Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA‑MB‑231 breast cancer cell line | Oncol Lett | shRNA | TF314712 |
| AR | Stromal Hyaluronan Interaction with Epithelial CD44 Variants Promotes Prostate Cancer Invasiveness by Augmenting Expression and Function of Hepatocyte Growth Factor and Androgen Receptor | J. Biol. Chem., Jun 2010; 285: 19821 - 19832 | shRNA | TR320265 |
| ARF6 | A critical role of Arf6 in the response of commissural axons to Slit | Development | shRNA | TR500130 |
| Arf6 | Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse | Elife | shRNA | TF710999 |
| Arf6 | Antagonistic Functions of Dishevelleds Regulate Frizzled3 Endocytosis via Filopodia Tips in Wnt-Mediated Growth Cone Guidance | J. Neurosci. Dec 2013. | shRNA | TG500130 |
| ARHGAP15 | Forkhead box P3 regulates ARHGAP15 expression and affects migration of glioma cells through the Rac1 signaling pathway | Cancer Sci | shRNA | TR306620 |
| ARHGDIA | Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression | Nat Commun | shRNA | TG314680 |
| ARHGEF17 | Phosphorylation of Cdc42 Effector Protein-4 (CEP4) by Protein Kinase C Promotes Motility of Human Breast Cells | J. Biol. Chem. | shRNA | TG314673 |
| ARHGEF9 | RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of α2 GABAA receptors | PLoS Genet.2017 | shRNA | TF517554 |
| ARID1A | A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment | Oncotarget | shRNA | TG306603 |
| Arid1a | BAF complexes facilitate decatenation of DNA by topoisomerase IIa | Nature 497, 624-627 doi:10.1038/nature12146 | shRNA | TG306603 |
| ARID2 | Essential Role of ARID2 Protein-containing SWI/SNF Complex in Tissue-specific Gene Expression | J. Biol. Chem., Feb 2012; 287: 5033 - 5041. | shRNA | TR306601 |
| ARNTL | Circadian Modulation of 8-Oxoguanine DNA Damage Repair | Sci Rep | shRNA | TR314656 |
| ARRB1 | A β-arrestin-2-dependent mechanism of GPR52 signalling in frontal cortical neurons | ACS Chem Neurosci | shRNA | TG510701 |
| ARRB1 | Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling | International Journal of Biological Science | shRNA | TG510701 |
| ARRB1 | Downregulation of β-arrestin 1 suppresses glioblastoma cell growth and glycolysis via inhibition of Src signaling | Exp. Cell Res. | shRNA | TR306568 |
| ARRB1 | β-Arrestin 1 has an essential role in neurokinin-1 receptor-mediated glioblastoma cell proliferation and G2/M phase transition | J. Biol. Chem | shRNA | TG306568 |
| ARRB1 | Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer | EMBO J. | shRNA | TG306568 |
| ARRB1 | Nodal signals via ß-arrestins and RalGTPases to regulate trophoblast invasion | Cell. Signal. | shRNA | TR306568 |
| ARRB1 | ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells | Mol. Cancer Res., Jul 2009; 7: 1064 - 1077 | shRNA | TR306568 |
| ARRB2 | A β-arrestin-2-dependent mechanism of GPR52 signalling in frontal cortical neurons | ACS Chem Neurosci | shRNA | TG517061 |
| ARRB2 | Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling | International Journal of Biological Science | shRNA | TF517061 |
| ARRB2 | β-Arrestin 1 has an essential role in neurokinin-1 receptor-mediated glioblastoma cell proliferation and G2/M phase transition | J. Biol. Chem | shRNA | TG306567 |
| ARRB2 | Beta-Arrestin-2 Counters CXCR7-mediated EGFR Transactivation and Proliferation | Mol. Cancer Res. | shRNA | TG306567 |
| ARRB2 | Nodal signals via ß-arrestins and RalGTPases to regulate trophoblast invasion | Cell. Signal. | shRNA | TR306567 |
| ARRB2 | ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells | Mol. Cancer Res., Jul 2009; 7: 1064 - 1077 | shRNA | TR306567 |
| ART1 | Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair | JCI Insight | shRNA | TG512773 |
| ASB4 | Expression of ankyrin repeat and SOCS box containing 4 (ASB4) confers migration and invasion properties of hepatocellular carcinoma cells | Biosci Trends | shRNA | TG306546 |
| ASCL1 | Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1 | Nat Commun | shRNA | TR314633 |
| ASF1B | Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components | PNAS, Feb 2010; 107: 2461 - 2466 | shRNA | TR317316 |
| Asns | Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series | Genome Med | shRNA | TG709676 |
| ASPN | The dual role of asporin in breast cancer progression | Oncotarget | shRNA | TR306531 |
| ASXL1 | ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis | Sci Adv | shRNA | TG306527 |
| ATAT1 | Tubulin Acetyltransferase aTAT1 Destabilizes Microtubules Independently of Its Acetylation Activity | Mol. Cell. Biol., Mar 2013; 33: 1114 - 1123. | shRNA | TR314302 |
| ATF6 | Insulin demand regulates ß cell number via the unfolded protein response | J. Clin. Invest. | shRNA | TR314613 |
| ATG10 | Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity | J. Virol., Mar 2011; 10.1128/JVI.02032-10 | shRNA | TR306517 |
| ATG5 | ATGs ubiquitination is required for circumsporozoite protein to subvert host innate immunity against malaria liver stage | bioRxiv | shRNA | TR314610 |
| ATG5 | Chloroquine reverses chemoresistance via upregulation of p21WAF1/CIP1 and autophagy inhibition in ovarian cancer | Cell death & disease | shRNA | TG314610 |
| ATG5 | An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z | PLoS ONE | shRNA | TR314610 |
| ATG5 | Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy | Autophagy | shRNA | TG314610 |
| ATG5 | Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells | J. Cell. Mol. Med. | shRNA | TF314610 |
| Atg5 | Autophagic Clearance of Mitochondria in the Kidney Copes with Metabolic Acidosis | Journal of the American Society of Nephrology : JASN | shRNA | TR500113 |
| ATG5 | Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity | J. Virol., Mar 2011; 10.1128/JVI.02032-10 | shRNA | TR314610 |
| ATG5 | Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death | Cell Death and Differentiation (8 October 2010) doi:10.1038/cdd.2010.117 Original Paper | shRNA | TR314610 |
| ATG5 | Energy Restriction as an Antitumor Target of Thiazolidinediones | J. Biol. Chem., Mar 2010; 285: 9780 - 9791 | shRNA | TR314610 |
| ATG7 | ATGs ubiquitination is required for circumsporozoite protein to subvert host innate immunity against malaria liver stage | bioRxiv | shRNA | TR314609 |
| ATG7 | Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells | J Cell Physiol | shRNA | TG504956 |
| ATG7 | Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer | Nat Commun | shRNA | TG504956 |
| ATG7 | Metformin prevents cell tumorigenesis through autophagy-related cell death | Sci Rep | shRNA | TG314609 |
| Atg7 | Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells | Elife | shRNA | TG504956 |
| Atg7 | Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation | Scientific Reports | shRNA | TF504956 |
| Atg7 | Autophagy is required and protects against apoptosis during myoblast differentiation | Biochem. J. | shRNA | TG504956 |
| ATG7 | Antagonism of tumoral prolactin receptor promotes autophagy-related cell death | Cell Rep 488-500 7 2. April 2014 | shRNA | TG314609 |
| ATG7 | Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response | shRNA | TG504956 | |
| Atg7 | Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens | Autophagy | shRNA | TR504956 |
| ATG7 | Energy Restriction as an Antitumor Target of Thiazolidinediones | J. Biol. Chem., Mar 2010; 285: 9780 - 9791 | shRNA | TR314609 |
| ATG7 | Eradication of Intracellular Salmonella Typhimurium with a Small-Molecule, Host Cell-Directed Agent | Antimicrob. Agents Chemother., Oct 2009; 10.1128/AAC.00555-09 | shRNA | TR504956 |
| ATM | ATM expression predicts Veliparib and Irinotecan sensitivity in gastric cancer by mediating P53 independent regulation of cell cycle and apoptosis | Mol. Cancer Ther. | shRNA | TR320267 |
| ATM | ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion | Elife | shRNA | TG320267 |
| ATP5PF | Over-Expression of the ATP5J Gene Correlates with Cell Migration and 5-Fluorouracil Sensitivity in Colorectal Cancer | PLoS One. 2013 Oct 4;8(10):e76846 | shRNA | TR314579 |
| Atp5pf | Over-Expression of the ATP5J Gene Correlates with Cell Migration and 5-Fluorouracil Sensitivity in Colorectal Cancer | PLoS ONE | shRNA | TL712002 |
| ATP6AP2 | (Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations | Br. J. Cancer | shRNA | TR314574 |
| ATP7A | A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity | J. Biol. Chem., Dec 2009; 284: 33949 - 33956 | shRNA | TR314562 |
| ATP7A | Copper transport into the secretory pathway is regulated by oxygen in macrophages | J. Cell Sci., May 2009; 122: 1315 - 1321. | shRNA | TR314562 |
| Atp7a | Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes | Nature 454, 1142 - 1146 (23 Jul 2008), doi: 10.1038/nature07163, Letter | shRNA | TR314562 |
| ATP7B | Copper ions are novel therapeutic agents for uterine leiomyosarcoma | Am. J. Obstet. Gynecol. | shRNA | TF314561 |
| AURKA | A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport | Cell reports | shRNA | TL320538 |
| AURKA | Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells | Cancer Biology & Therapy | shRNA | TR320538 |
| AURKB | Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells | Cancer Biology & Therapy | shRNA | TR320607 |
| B2M | A Subset of Human Autoreactive CD1c-Restricted T Cells Preferentially Expresses TRBV4-1+ TCRs | J. Immunol. | shRNA | TR314543 |
| B2M | Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors | PLoS ONE | shRNA | TR314543 |
| B3GALNT1 | Human Intestinal Tissue and Cultured Colonic Cells Contain Globotriaosylceramide Synthase mRNA and the Alternate Shiga Toxin Receptor, Globotetraosylceramide | Infect. Immun., Nov 2010; 78: 4488 - 4499 | shRNA | TR306471 |
| Babam2 | Anti-apoptotic protein BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase inhibitor XIAP in mouse Lewis lung carcinoma D122 cells | Apoptosis, Jan 2014. | shRNA | TG505808 |
| BAG3 | A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy | Cell Death Dis | shRNA | TR314524 |
| BAK1 | Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability | Mol. Neurobiol. | shRNA | TF712171 |
| BAK1 | BAX/BAK–Independent Mitoptosis during Cell Death Induced by Proteasome Inhibition | Mol. Cancer Res., Aug 2009; 7: 1268 - 1284 | shRNA | TR314515 |
| BAX | Secreted frizzled-related protein 5 protects against oxidative stress-induced apoptosis in human aortic endothelial cells via downregulation of Bax | J. Biochem. Mol. Toxicol. | shRNA | TR306440 |
| BAX | Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability | Mol. Neurobiol. | shRNA | TF709871 |
| BAZ1B | DNA damage response defect in Williams-Beuren syndrome | Int. J. Mol. Med. | shRNA | TG306439 |
| BAZ1B | PLA2G16 represents a switch between entry and clearance of Picornaviridae | Nature | shRNA | TG306439 |
| BCDIN3D | BCDIN3D regulates tRNAHis 3' fragment processing | PLoS Genet. | shRNA | TR317908 |
| BCL11B | A novel 4-dimensional live-cell imaging system to study leukocyte-endothelial dynamics in ANCA-associated vasculitis | Autoimmunity | shRNA | TR306424 |
| Bcl11b | Striatal Neurodevelopment Is Dysregulated in Purine Metabolism Deficiency and Impacts DARPP-32, BDNF/TrkB Expression and Signaling: New Insights on the Molecular and Cellular Basis of Lesch-Nyhan Syndrome | PLoS ONE | shRNA | TL515999 |
| BCL2 | IL-13 in LPS-Induced Inflammation Causes Bcl-2 Expression to Sustain Hyperplastic Mucous cells | Sci Rep | shRNA | TG316461 |
| BCL2 | Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner | J. Allergy Clin. Immunol. | shRNA | TR316461 |
| BCL2 | Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in BclxL silenced glioma cell lines | Molecular carcinogenesis | shRNA | TR316461 |
| BCL2 | Parecoxib Protects Mouse Cortical Neurons Against OGD/R Induced Neurotoxicity by Up-Regulating Bcl-2 | Neurochem. Res. | shRNA | TG316461 |
| Bcl2a1 | The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment | Cancers | shRNA | TL712645 |
| BCL2L11 | RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy | Autophagy | shRNA | TG306422 |
| BDNF | A unique homeostatic signaling pathway links synaptic inactivity to postsynaptic mTORC1 | J. Neurosci. | shRNA | TG306410 |
| BECN1 | Autophagy Exacerbates Muscle Wasting in Cancer Cachexia and Impairs Mitochondrial Function | J. Mol. Biol. | shRNA | TG503112 |
| BECN1 | HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells | Cell Death Dis | shRNA | TG314484 |
| BECN1 | RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy | Autophagy | shRNA | TG314484 |
| BECN1 | Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells | J. Cell. Mol. Med. | shRNA | TF314484 |
| BECN1 | Antagonism of tumoral prolactin receptor promotes autophagy-related cell death | Cell Rep 488-500 7 2. April 2014 | shRNA | SC117750 |
| BECN1 | From autophagy to senescence and apoptosis in Angiotensin II-treated vascular endothelial cells | APMIS | shRNA | TG314484 |
| BECN1 | Enhancement of Autophagy during Lytic Replication by the Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Activator | J. Virol., Aug 2010; 84: 7448 - 7458 | shRNA | TR314484 |
| BECN1 | Eradication of Intracellular Salmonella Typhimurium with a Small-Molecule, Host Cell-Directed Agent | Antimicrob. Agents Chemother., Oct 2009; 10.1128/AAC.00555-09 | shRNA | TR314484 |
| BID | Inhibition of O-GlcNAcase sensitizes apoptosis and reverses bortezomib resistance in mantle cell lymphoma through modification of truncated Bid | Mol. Cancer Ther.2017 | shRNA | TF314477 |
| BIK | Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria | Nat Commun | shRNA | TF500209 |
| BIRC5 | Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells | Cancer Biology & Therapy | shRNA | TR315477 |
| BIRC5 | Molecular Chaperone gp96 Is a Novel Therapeutic Target of Multiple Myeloma | Clin Cancer Res. 2013 Nov 15;19(22):6242-51 | shRNA | TG315477 |
| BIRC5 | IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin | Blood, Jan 2011; 117: 352 - 361 | shRNA | TR315477 |
| BLM | ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1-BLM Interaction. | Cells | shRNA | TR314471 |
| BMF | Bmf Facilitates Protein Degradation and Reduces Beclin1 Ubiquitination to Inhibit Autophagy Independent of mTOR | bioRxiv | shRNA | TR314463 |
| BMI1 | Polycomb protein BMI1 regulates osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells downstream of GSK3 | Stem Cells Dev. | shRNA | TG314462 |
| BMI1 | BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair | J. Cell Biol., Oct 2010; 191: 45 - 60 | shRNA | TR314462 |
| BMP4 | BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells | Mol Ther Nucleic Acids | shRNA | TF306390 |
| BMP4 | Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression | OncoImmunology | shRNA | TG516759 |
| BMP4 | BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells | Mol. Cancer | shRNA | TG516759 |
| BMX | BMX negatively regulates BAK function thereby increasing apoptotic resistance to chemotherapeutic drugs | Cancer Res. | shRNA | TR320275 |
| BMX | Bone Marrow X Kinase–Mediated Signal Transduction in Irradiated Vascular Endothelium | Cancer Res., Apr 2008; 68: 2861 - 2869. | shRNA | TR320275 |
| BNIP3 | Role of HIF-1a in regulating autophagic cell survival during cerebral ischemia reperfusion in rats | Oncotarget | shRNA | TG316465 |
| BNIP3 | Autophagy Induction Results in Enhanced Anoikis-resistance in Models of Peritoneal Disease | Mol. Cancer Res. | shRNA | TR316465 |
| BNIP3 | Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis | J. Cell Biol., Jul 2012; 198: 103 - 114. | shRNA | TR316465 |
| Bnip3 | Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis | The Journal of Cell Biology | shRNA | TG500221 |
| BNIP3L | Role of HIF-1a in regulating autophagic cell survival during cerebral ischemia reperfusion in rats | Oncotarget | shRNA | TG316466 |
| BRAF | Lactate Dehydrogenase A as a Potential New Biomarker for Thyroid Cancer | Endocrinology and metabolism (Seoul, Korea) 2021 | shRNA | TR320276 |
| Brca1 | A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. | Molecular cell | shRNA | TF515706 |
| BSG | Secreted cyclophilin A mediates G1/S phase transition of cholangiocarcinoma cells via CD147/ERK1/2 pathway | Tumour Biol. | shRNA | TG314429 |
| BST2 | The interferon-induced protein BST-2/CD317 restricts release of virions from infected cells and is down-regulated from the cell surface by HIV-1 Vpu | Cell Host Microbe. 2008 April 17; 3(4): 245-252 | shRNA | TR314427 |
| C10orf90 | FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage | Oncogene | shRNA | TG315108 |
| CA2 | Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy | J Am Heart Assoc | shRNA | TG314258 |
| CA9 | Inhibition of carbonic anhydrase IX (CA9) sensitizes renal cell carcinoma to ionizing radiation | Oncol. Rep. | shRNA | TG314250 |
| CA9 | Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy | Clin. Cancer Res., Jun 2012; 18: 3100 - 3111. | shRNA | TR314250 |
| CA9 | Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation. | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology | shRNA | TR314250 |
| CABP7 | Modulation of Phosphatidylinositol 4-Phosphate levels by CaBP7 controls cytokinesis in mammalian cells | Mol. Biol. Cell | shRNA | TG305684 |
| CACNA1C | STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry | J. Mol. Med. | shRNA | TF314247 |
| CACNA1F | Mutation of an L-Type Calcium Channel Gene Leads to a Novel Human Primary Cellular Immunodeficiency | BioRxiv | shRNA | TG314244 |
| CALCR | Amylin Modulates the Mesolimbic Dopamine System toControl Energy Balance | Neuropsychopharmacology | shRNA | TG712173 |
| CALCR | Reductions of the components of the calreticulin/calnexin quality-control system by proteasome inhibitors and their relevance in a rodent model of Parkinson's disease | J. Neurosci. Res. | shRNA | TG314223 |
| CALD1 | Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development | Clin. Cancer Res., Jun 2010; 16: 3193 - 3204 | shRNA | TR305670 |
| CALR | Calreticulin Regulates Syncytialization Through Control of the Synthesis and Transportation of E-Cadherin in BeWo Cells | Endocrinology | shRNA | TR314216 |
| CALU | Enhanced Functional Recombinant Factor VII Production by HEK 293 Cells Stably Transfected with VKORC1 where the Gamma-Carboxylase Inhibitor Calumenin is Stably Suppressed by shRNA Transfection | shRNA | TR314215 | |
| CALU | Enhanced Functional Recombinant Factor VII Production by HEK 293 Cells Stably Transfected with VKORC1 where the Gamma-Carboxylase Inhibitor Calumenin is Stably Suppressed by shRNA Transfection | shRNA | TL314215 | |
| CALU | Enhanced functional recombinant factor VII production by HEK 293 cells stably transfected with VKORC1 where the gamma-carboxylase inhibitor calumenin is stably suppressed by shRNA transfection | Thrombosis Research Volume 122, Issue 3, 2008, Pages 405-410 | shRNA | TR314215 |
| CALY | Coupling of microtubule motors with AP-3 generated organelles in axons by NEEP21 Family Member Calcyon | Mol. Biol. Cell | shRNA | TG712969 |
| CAMKK2 | Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase | Am J Transl Res | shRNA | TF320643 |
| CAMP | Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production | Gut Microbes | shRNA | TG314213 |
| CAMP | Human cathelicidin improves colonic epithelial defenses against Salmonella typhimurium by modulating bacterial invasion, TLR4 and pro-inflammatory cytokines | Cell Tissue Res. | shRNA | TG314213 |
| CAMP | Cathelicidin senses enteric pathogen Salmonella typhimurium/LPS for colonic chemokine generation: a new innate immune role for a host defense peptide | bioRxiv | shRNA | TG314213 |
| Car1 | Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity | Journal for Immunotherapy of Cancer | shRNA | TL510087 |
| Car2 | Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy | J Am Heart Assoc | shRNA | TG710298 |
| CARD11 | MiR-539 inhibits thyroid cancer cell migration and invasion by directly targeting CARMA1 | Biochem. Biophys. Res. Commun. | shRNA | TG305653 |
| CASK | The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons | Neurosci. Lett. | shRNA | TG516864 |
| CASK | CNTNAP2 stabilizes interneuron dendritic arbors through CASK | Mol. Psychiatry | shRNA | TG516864 |
| CASK | Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes | Circ. Res. | shRNA | TF320586 |
| CASK | Organisation et régulation des canaux sodiques et potassiques cardiaques par les protéines MAGUK | Thesis | shRNA | TF320586 |
| CASP1 | Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis | MBio | shRNA | TG305640 |
| CASP12 | Modulation of Plasmid DNA Vaccine Antigen Clearance by Caspase 12 RNA interference (RNAi) Potentiates Vaccination | Clin. Vaccine Immunol., Feb 2011; 10.1128/CVI.00390-10 | shRNA | TR500273 |
| CASP6 | Several Nuclear Events during Apoptosis Depend on Caspase-3 Activation but Do Not Constitute a Common Pathway | PLoS ONE 4(7): e6234. doi:10.1371/journal.pone.0006234 | shRNA | TR307410 |
| CASP8 | Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice | J. Exp. Med. | shRNA | TG305635 |
| CASR | Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H | Proc. Natl. Acad. Sci. U.S.A. | shRNA | TF513061 |
| CAT | Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism | Sci Rep | shRNA | TR314184 |
| CAT | Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells | Toxicol. Appl. Pharmacol. | shRNA | TG314184 |
| CAT | Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells | Toxicol. Appl. Pharmacol. | shRNA | TR314184 |
| CAT | Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis | J. Biol. Chem. | shRNA | TG314184 |
| CAT | Role of reactive oxygen species in arsenic-induced transformation of human lung bronchial epithelial (BEAS-2B) cells | Biochem. Biophys. Res. Commun. | shRNA | TF314184 |
| CAV1 | Chrysotobibenzyl inhibition of lung cancer cell migration through Caveolin-1-dependent mediation of the integrin switch and the sensitization of lung cancer cells to cisplatin-mediated apoptosis | Phytomedicine | shRNA | TG314183 |
| CAV1 | Loss of caveolin-1 in cancer associated fibroblasts promotes hepatocellular carcinoma development | Int J Clin Exp Med | shRNA | TG314183 |
| CAV1 | Aberrant Promoter Methylation of Caveolin-1 Is Associated with Favorable Response to Taxane-Platinum Combination Chemotherapy in Advanced NSCLC | PLoS ONE | shRNA | TF314183 |
| CAV1 | Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein | J. Biol. Chem., Sep 2011; 286: 30780 - 30794. | shRNA | TR314183 |
| Cav1 | Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein | The Journal of Biological Chemistry | shRNA | TL500281 |
| CAVIN1 | Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma | Lab. Invest. | shRNA | TR310045 |
| CAVIN1 | SDPR induces membrane curvature and functions in the formation of caveolae | Nat Cell Biol. 2009 Jul;11(7):807-14. | shRNA | TR310045 |
| CAVIN4 | MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line | PLoS ONE | shRNA | TG315318 |
| Cbfb | Functions of Smad Transcription Factors in TGF-ß1-Induced Selectin Ligand Expression on Murine CD4 Th Cells | J. Immunol. | shRNA | TR500286 |
| CBLN4 | Cerebellin 4, a synaptic protein that enhances inhibitory activity and resistance of neurons to Amyloid beta toxicity | Neurobiology of Aging | shRNA | TG516844 |
| CBX4 | CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage | Nucleic Acids Res., Mar 2012; 10.1093/nar/gks222. | shRNA | TR314171 |
| CBX8 | Upregulated CBX8 promotes cancer metastasis via the WNK2/MMP2 pathway | Molecular Therapy - Oncolytics | shRNA | TF317361 |
| CCAR2 | ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1-BLM Interaction. | Cells | shRNA | TR303704 |
| Ccl17 | Intratumoral IFN-α gene delivery reduces tumor-infiltrating regulatory T cells through the downregulation of tumor CCL17 expression. | Cancer gene therapy | shRNA | TL501986 |
| CCL19 | CCR7/CCL19 Controls Expression of EDG-1 in T Cells | J. Biol. Chem., Apr 2012; 287: 11656 - 11664. | shRNA | TR319889 |
| CCN4 | WISP1, a Pro-mitogenic, Pro-survival Factor, Mediates Tumor Necrosis Factor- (TNF-)-stimulated Cardiac Fibroblast Proliferation but Inhibits TNF--induced Cardiomyocyte Death | J. Biol. Chem., May 2009; 284: 14414 - 14427 | shRNA | TR300454 |
| CCNA2 | CCNA2 facilitates epithelial-to-mesenchymal transition via the integrin αvβ3 signaling in NSCLC | International Journal of Clinical and Experimental Pathology | shRNA | TL315479 |
| Ccna2 | CCN1 induces a reversible epithelial–mesenchymal transition in gastric epithelial cells | Laboratory Investigation (10 May 2010) doi:10.1038/labinvest.2010.101 Research Article | shRNA | TR712084 |
| CCND1 | PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition | Mol. Carcinog. | shRNA | TG305536 |
| CCND3 | L-Arginine availability regulates T lymphocyte cell cycle progression | Blood. 2007 Feb 15;109(4):1568-73. | shRNA | TR320286 |
| CCNI | CDK6 is activated by the atypical cyclin I to promote E2F ‐mediated gene expression and cancer cell proliferation | Molecular Oncology | shRNA | TL314135 |
| CCR4 | A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer | J. Clin. Invest | shRNA | TR314127 |
| CCR4 | A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer | J. Clin. Invest | shRNA | TR500386 |
| CCR7 | The role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis | Molecular Cancer | shRNA | TF314124 |
| CD109 | CD109 plays a role in osteoclastogenesis | PLoS ONE Apr2013 | shRNA | TG507140 |
| CD2 | Epigenetic Inactivation of the BRCA1 Interactor SRBC and Resistance to Oxaliplatin in Colorectal Cancer | J. Natl. Cancer Inst. | shRNA | TG314102 |
| CD24 | Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation | Exp. Mol. Med. | shRNA | TG321436 |
| CD24 | Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents | PLoS ONE | shRNA | TR321436 |
| Cd274 | Targeting the secreted RGDKGE collagen fragment reduces PD‑L1 by a proteasome‑dependent mechanism and inhibits tumor growth. | Oncology reports | shRNA | TL503436 |
| CD274 | Inhibition of Tumor Growth and Sensitization to Sunitinib by RNA Interference Targeting Programmed Death-ligand 1 in Mouse Renal Cell Carcinoma RenCa Model | Anticancer Res. | shRNA | TG314098 |
| CD274 | PD‐L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation | International Journal of Cancer | shRNA | TR314098 |
| CD274 | Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: significance in claudin-low breast cancer cells | Mol. Cancer | shRNA | TG314098 |
| CD274 | Investigating the role of PD-L1 pathway in human ovarian cancer | Thesis | shRNA | TG314098 |
| CD276 | Role of MYC-miR-29-B7-H3 in Medulloblastoma Growth and Angiogenesis | J Clin Med | shRNA | TR317545 |
| CD36 | Lipid oversupply induces CD36 sarcolemmal translocation via dual modulation of PKCζ and TBC1D1: an early event prior to insulin resistance | Theranostics | shRNA | TG314090 |
| CD38 | Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes | J. Cell. Mol. Med. | shRNA | TR314088 |
| CD40 | Overexpression of CCN1 in Het1A cells attenuates bile-induced esophageal metaplasia through suppressing non-canonical NFκB activation | Cytokine | shRNA | TR314082 |
| CD44 | CD44-shRNA recombinant adenovirus inhibits cell proliferation, invasion, and migration, and promotes apoptosis in HCT116 colon cancer cells | Int. J. Oncol | shRNA | TG314080 |
| CD44 | Targeting Cancer Stem Cells in Castration-Resistant Prostate Cancer | Clin. Cancer Res | shRNA | TG314080 |
| CD44 | Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry | Nitric Oxide | shRNA | TR314080 |
| CD44 | alpha3/4 Fucosyltransferase 3-Dependent Synthesis of Sialyl Lewis A on CD44 Variant Containing Exon 6 Mediates Polymorphonuclear Leukocyte Detachment from Intestinal Epithelium during Transepithelial Migration | J Immunol. 2013 Nov 1;191(9):4804-17 | shRNA | TG314080 |
| CD44 | CD44 Proteolysis Increases CREB Phosphorylation and Sustains Proliferation of Thyroid Cancer Cells | Cancer Res., Mar 2012; 72: 1449 - 1458. | shRNA | TR314080 |
| CD44 | Neutrophil Migration across Intestinal Epithelium: Evidence for a Role of CD44 in Regulating Detachment of Migrating Cells from the Luminal Surface | J. Immunol., Dec 2010; 185: 7026 - 7036 | shRNA | TR314080 |
| CD44 | Stimulation of TLRs by LMW-HA induces self-defense mechanisms in vaginal epithelium | Immunology and Cell Biology (23 November 2010) doi:10.1038/icb.2010.140 Original Article | shRNA | TR314080 |
| Cd47 | High expression of CD47 predicts adverse prognosis in Chinese patients and suppresses immune response in melanoma. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | shRNA | TL501123 |
| CD9 | Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion | Sci Rep | shRNA | TR314060 |
| CD9 | Different states of integrin LFA-1 aggregation are controlled through its association with tetraspanin CD9 | Biochim. Biophys. Acta | shRNA | TR314060 |
| CDC42 | Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression | Nat Commun | shRNA | TG305497 |
| Cdc42 | Integrating transient cellular and nuclear motions to comprehensively describe cell migration patterns | Sci Rep | shRNA | TF510719 |
| CDC42 | IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway | J. Cell Sci., Jun 2009; 122: 2024 - 2033 | shRNA | TR305497 |
| CDC73 | A role for the RNA pol II–associated PAF complex in AID-induced immune diversification | J. Exp. Med., Oct 2012; 209: 2099 - 2111. | shRNA | TG305495 |
| CDC73 | A role for the RNA pol II–associated PAF complex in AID-induced immune diversification | J. Exp. Med., Sep 2012; 10.1084/jem.20112145. | shRNA | TR305495 |
| CDH1 | Downregulation of E-cadherin is an essential event in activating bold beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells | Oncogene advance online publication 28 September 2009; doi: 10.1038/onc.2009.302 | shRNA | TR314042 |
| CDH11 | Reciprocal regulation of the Cadherin-11/Stat3 axis by caveolin-1 in mouse fibroblasts and lung carcinoma cells | Biochim. Biophys. Acta | shRNA | TF509242 |
| CDH2 | Specific N-cadherin-dependent pathways drive human breast cancer dormancy in bone marrow | Life science alliance | shRNA | TF314034 |
| CDH2 | The FGFR4-388arg Variant Promotes Lung Cancer Progression by N-Cadherin Induction | Sci Rep | shRNA | HC138304 |
| CDH26 | Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity | Cell Discov | shRNA | TF305478 |
| Cdh3 | A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration | Developmental cell | shRNA | TL500332 |
| CDH3 | A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration | Developmental cell | shRNA | TL314033 |
| CDH3 | HOXA9 promotes homotypic and heterotypic cell interactions that facilitate ovarian cancer dissemination via its induction of P-cadherin | Mol. Cancer July 2014 | shRNA | TG314033 |
| CDIP1 | Expression of the p53 Target CDIP Correlates with Sensitivity to TNFa-Induced Apoptosis in Cancer Cells | Cancer Res., May 2012; 72: 2373 - 2382. | shRNA | TR315650 |
| CDK4 | Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways | PLoS ONE | shRNA | TG320293 |
| CDK5 | The HU177 Collagen Epitope Controls Melanoma Cell Migration and Experimental Metastasis by a CDK5/YAP-Dependent Mechanism | Am. J. Pathol. | shRNA | TG515615 |
| CDKN1A | Chloroquine reverses chemoresistance via upregulation of p21WAF1/CIP1 and autophagy inhibition in ovarian cancer | Cell death & disease | shRNA | TG305469 |
| CDKN1A | 15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPAR?-mediated activation of p21WAF1/Cip1 | Oncogene doi:10.1038/onc.2013.69 | shRNA | TG305469 |
| CDKN1A | Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models | Mol. Cancer Ther., Feb 2009; 8: 342 - 349 | shRNA | TR305469 |
| CDKN1A | Enhanced Antitumor Therapy by Inhibition of p21waf1 in Human Malignant Mesothelioma | Clin. Cancer Res., Aug 2008; 14: 5099 - 5107 | shRNA | TR305469 |
| CDKN1B | Kaposi's Sarcoma-Associated Herpesvirus Transactivator Rta Induces Cell Cycle Arrest in G0/G1 Phase by Stabilizing and Promoting Nuclear Localization of p27kip | J. Virol. 13226-38 | shRNA | TR314022 |
| CDKN1B | KSHV encoded Rta induces cell cycle arrest | J. Virol. Dec 2013. | shRNA | TG314022 |
| CDKN2B | Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo | PNAS, Mar 2013; 110: 4634 - 4639. | shRNA | TG320299 |
| CEBPA | Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells | PLoS ONE | shRNA | TF316491 |
| CEBPB | Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer | Journal of Experimental & Clinical Cancer Research : CR | shRNA | TL320301 |
| CEBPB | A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer\'s disease pathologies | Brain : a journal of neurology | shRNA | TR710974 |
| Cebpb | Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths | Cell reports | shRNA | TF500345 |
| Cebpd | Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths | Cell reports | shRNA | TF500346 |
| CEL | Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma | Oncogene | shRNA | TR313998 |
| Cela1 | Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development | American Journal of Physiology - Lung Cellular and Molecular Physiology | shRNA | TL709197 |
| CELF1 | Translational derepression of Elavl4 isoforms at their alternative 5\' UTRs determines neuronal development | Nat Commun | shRNA | TF514753 |
| Celf1 | Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines | Mol. Biol. Cell, Sep 2011; 22: 3055 - 3069. | shRNA | TR514753 |
| CENPB | A two-step mechanism for epigenetic specification of centromere identity and function | Nature Cell Biology doi:10.1038/ncb2805 | shRNA | TG313993 |
| CENPJ | Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1 | Nat Commun | shRNA | TG305452 |
| CEP55 | Suppression of CEP55 reduces cell viability and induces apoptosis in human lung cancer | Oncol. Rep. | shRNA | TR305437 |
| CEPT1 | Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets | Nature communications | shRNA | TR313975 |
| CFLAR | Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure | Digestive and Liver Disease | shRNA | TR313960 |
| CFLAR | Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates | Nat. Med | shRNA | TG500356 |
| CFLAR | TNF Apoptosis Protection Fraction (TAPF) prevents apoptosis induced by TNF, but not by Fas or TRAIL, via NF-?B-induced increase in cFLIP | Cytokine | shRNA | TR313960 |
| CFLAR | Inhibition of NF-{kappa}B Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin | J. Biol. Chem., Jun 2010; 285: 19162 - 19172 | shRNA | TR313960 |
| CFTR | High CFTR expression in Philadelphia chromosome-positive acute leukemia protects and maintains continuous activation of BCR-ABL and related signaling pathways in combination with PP2A | Oncotarget | shRNA | TG313958 |
| CFTR | High level of CFTR expression is associated with tumor aggression and knockdown of CFTR suppresses proliferation of ovarian cancer in vitro and in vivo | Oncol. Rep. | shRNA | TG313958 |
| CGAS | Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes. | JCI insight | shRNA | TL305813 |
| CHCHD3 | ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function | J. Biol. Chem., Jan 2011; 286: 2918 - 2932 | shRNA | TR305418 |
| CHCHD4 | Glutathionylated and Fe-S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain | Redox biology | shRNA | TG305417 |
| CHCHD4 | Human Mitochondrial MIA40 (CHCD4) is a component of Fe/S cluster export machinery | Biochem. J. | shRNA | TR305417 |
| CHD1 | The Role of CHD1 in DNA Rearrangements and Progression of Prostate Cancer | Grant | shRNA | TR313946 |
| CHD4 | CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells | International journal of molecular sciences | shRNA | TR313943 |
| CHEK1 | Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma | Translational Oncology | shRNA | TR320302 |
| CHI3L1 | YKL-40 regulated epithelial-mesenchymal transition and migration/invasion enhancement in non-small cell lung cancer | BMC Cancer | shRNA | TR316497 |
| CHPT1 | Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets | Nature communications | shRNA | TR305398 |
| CHRM3 | Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression | Int. Immunopharmacol. | shRNA | TR313926 |
| CHRM4 | Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression | Int. Immunopharmacol. | shRNA | TR313925 |
| CHRNA3 | Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression | Int. Immunopharmacol. | shRNA | TR313921 |
| CHRNA3 | Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors | BMC Cancer | shRNA | TG313921 |
| CHRNA4 | Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors | BMC Cancer | shRNA | TG313920 |
| CHRNA7 | Apolipoprotein (a)/Lipoprotein(a)-Induced Oxidative-Inflammatory α 7-nAChR/p38 MAPK/IL-6/RhoA-GTP Signaling Axis and M1 Macrophage Polarization Modulate Inflammation-Associated Development of Coronary Artery Spasm | Oxidative Medicine and Cellular Longevity | shRNA | TG313917 |
| CHRNA7 | Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression | Int. Immunopharmacol. | shRNA | TR313917 |
| CHRNA7 | Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors | BMC Cancer | shRNA | TG313917 |
| CHRNA9 | Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression | Int. Immunopharmacol. | shRNA | TR305392 |
| CHRNA9 | Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors | BMC Cancer | shRNA | TG305392 |
| CIITA | Pollen-induced antigen presentation by mesenchymal stem cells and T cells from allergic rhinitis | Clinical & Translational Immunology (2013) 2, e7 | shRNA | TR313899 |
| CISH | MicroRNA-98 and let-7 Confer Cholangiocyte Expression of Cytokine-Inducible Src Homology 2-Containing Protein in Response to Microbial Challenge | J. Immunol., Aug 2009; 183: 1617 - 1624 | shRNA | TR316498 |
| CITED1 | CITED1 promotes proliferation of papillary thyroid cancer cells via the regulation of p21 and p27 | Cell Biosci | shRNA | TR313896 |
| CKAP4 | The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer | Cell Death Dis | shRNA | TG506478 |
| Ckmt1 | A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling | The EMBO Journal | shRNA | TF512727 |
| CLDN1 | Claudin-1 induces epithelial–mesenchymal transition through activation of the c-Abl-ERK signaling pathway in human liver cells | Oncogene doi: 10.1038/onc.2012.505 | shRNA | TR305370 |
| Cldn3 | Claudin-4 is required for AMPK-modulated paracellular permeability in submandibular gland cells | J Mol Cell Biol | shRNA | TG711499 |
| Cldn4 | Claudin-4 is required for AMPK-modulated paracellular permeability in submandibular gland cells | J Mol Cell Biol | shRNA | TG701533 |
| Cltc | Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning | Dev. Cell2017 | shRNA | TF710306 |
| Cltc | Dysregulation of nectin-2 in the testicular cells: An explanation of cadmium-induced male infertility | Biochim. Biophys. Acta July 2014 | shRNA | TG516542 |
| CNR1 | The role of CB1 in intestinal permeability and inflammation | The FASEB Journal | shRNA | TR316500 |
| CNR1 | Cannabinoid Receptors Modulate Neuronal Morphology and AnkyrinG Density at the Axon Initial Segment | Front Cell Neurosci | shRNA | TG512614 |
| CNR1 | Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy | Diabetes, Sep 2011; 60: 2386 - 2396. | shRNA | TR316500 |
| CNTNAP2 | The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons | Neurosci. Lett. | shRNA | TG510300 |
| CNTNAP2 | CNTNAP2 stabilizes interneuron dendritic arbors through CASK | Mol. Psychiatry | shRNA | TG510300 |
| Cntnap2 | Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2 /Caspr2 knockout neurons | Proceedings of the National Academy of Sciences of the United States of America | shRNA | TL510300 |
| COG4 | Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene | PNAS, Aug 2009; 106: 13329 - 13334 | shRNA | TR317052 |
| Col1a2 | Targeting the secreted RGDKGE collagen fragment reduces PD‑L1 by a proteasome‑dependent mechanism and inhibits tumor growth. | Oncology reports | shRNA | TL500407 |
| COL23A1 | Collagen XXIII: A Potential Biomarker for the Detection of Primary and Recurrent Non–Small Cell Lung Cancer | Cancer Epidemiol. Biomarkers Prev., May 2010; 19: 1362 - 1372 | shRNA | TR317712 |
| COL6A1 | Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer | Clin. Cancer Res. | shRNA | TF500404 |
| COL6A1 | Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer | Clin. Cancer Res. | shRNA | MG223027 |
| COMMD7 | COMMD7 is correlated with a novel NF-?B positive feedback loop in hepatocellular carcinoma | Oncotarget | shRNA | TR305276 |
| COPRS | Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells | Sci Rep | shRNA | TF306098 |
| COPS5 | Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells | Br. J. Cancer | shRNA | TR313776 |
| COQ4 | Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency | J. Med. Genet., Mar 2012; 49: 187 - 191. | shRNA | TR305264 |
| CPT1C | Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress | Genes & Dev., May 2011; 25: 1041 - 1051 | shRNA | TR305235 |
| CRBN | Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41 | Cancer Research | shRNA | TG305228 |
| CREB1 | Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics | Transl Psychiatry | shRNA | TG313740 |
| CREB1 | Genetic Evidence for Critical Roles of P38a Protein in Regulating Mast Cell Differentiation and Chemotaxis through Distinct Mechanisms | J. Biol. Chem., Jun 2012; 287: 20258 - 20269. | shRNA | TR313740 |
| CREB3L3 | Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths | Cell Rep | shRNA | TF513785 |
| CREBBP | Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells | Cell Death Dis | shRNA | TF712619 |
| CREBBP | Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer | Nature Genetics 44, 1104-1110 doi:10.1038/ng.2396 | shRNA | TR313738 |
| CREG1 | CREG1 promotes lysosomal biogenesis and function | Autophagy | shRNA | TF510293 |
| Creg1 | CREG promotes vasculogenesis by activation of VEGF/PI3K/Akt pathway | Frontiers in Bioscience | shRNA | TG510293 |
| CRYAB | Inhibition of the Expression of the Small Heat Shock Protein aB-crystallin Inhibits Exosome Secretion in Human Retinal Pigment Epithelial Cells in Culture | J. Biol. Chem. | shRNA | TG313715 |
| CSF1 | miR-1254 inhibits progression of glioma in vivo and in vitro by targeting CSF-1 | J. Cell. Mol. Med. | shRNA | TG305200 |
| CSF1 | Colony-stimulating factor 1 potentiates lung cancer bone metastasis | Lab. Invest., Jan 2014. | shRNA | TG305200 |
| CSF2 | Autophagy inhibition by sustained over-production of IL-6 contributes to arsenic-induced carcinogenesis | Cancer Res. | shRNA | TF313703 |
| CSF2 | Immune-Dependent and Independent Antitumor Activity of GM-CSF Aberrantly Expressed by Mouse and Human Colorectal Tumors | Cancer Res., Jan 2013; 73: 395 - 405. | shRNA | MC208342 |
| Csk | Decreased levels of RGS4 in the paraventricular nucleus facilitate GABAergic inhibition during the acute stress response. | Biochemical and biophysical research communications | shRNA | TG510981 |
| CSK | SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines | Am J Pathol. 2007 Jan;170(1):366-76. | shRNA | TR320311 |
| CSMD1 | Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma | Breast Cancer Res Treat DOI 10.1007/s10549-009-0500-4 | shRNA | TR305196 |
| CSNK2A1 | Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2 | International journal of molecular sciences | shRNA | TG320317 |
| CSNK2A1 | Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia | Int J Mol Sci | shRNA | TG514070 |
| CSNK2A1 | Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide | Oncogene | shRNA | TG320317 |
| CSNK2A1 | Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia | Oncotarget | shRNA | TG320317 |
| CTCF | Identification of CTCF as a master regulator of the clustered protocadherin genes | Nucleic Acids Res., Dec 2011; 10.1093/nar/gkr1260. | shRNA | TR313675 |
| CTCFL | Downregulation of BORIS/CTCFL leads to ROS-dependent cellular senescence and drug sensitivity in MYCN-amplified neuroblastoma. | The FEBS journal | shRNA | TR305184 |
| CTCFL | BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung Cancer | Clin. Cancer Res., Jul 2011; 17: 4267 - 4276. | shRNA | TR305184 |
| CTCFL | Widespread Expression of BORIS/CTCFL in Normal and Cancer Cells | PLoS ONE | shRNA | TG305184 |
| CTCFL | BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression | Mol. Cell. Biol. 2008; 28(21): p. 6720-6729 | shRNA | TR305184 |
| CTCFL | DNA Methyltransferase 1 and 3B Activate BAG-1 Expression via Recruitment of CTCFL/BORIS and Modulation of Promoter Histone Methylation | Cancer Res., Apr 2008; 68: 2726 - 2735 | shRNA | TR305184 |
| CTH | Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis | EMBO Rep. | shRNA | TF313670 |
| CTNNB1 | Cell dynamics in Hertwig\'s epithelial root sheath are regulated by β-catenin activity during tooth root development | Journal of cellular physiology | shRNA | TG500280 |
| CTNNB1 | Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death | Cell Death Dis | shRNA | TG313664 |
| CTNNB1 | ß-Catenin Activates the HOXA10 and CDX4 Genes in Myeloid Progenitor Cells | J. Biol. Chem., Nov 2012; 287: 39589 - 39601. | shRNA | TG313664 |
| Ctnnb1 | HSulf-1 inhibits cell proliferation and invasion in human gastric cancer. | Cancer science | shRNA | TL711793 |
| CTNND1 | P120ctn may participate in epithelial-mesenchymal transition in OSCC | Indian J Cancer | shRNA | TF313663 |
| CTNND2 | d-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles | Molecular Cancer 2009, 8:19 | shRNA | TR313662 |
| CTR9 | A role for the RNA pol II–associated PAF complex in AID-induced immune diversification | J. Exp. Med., Oct 2012; 209: 2099 - 2111. | shRNA | TG313659 |
| CTR9 | A role for the RNA pol II–associated PAF complex in AID-induced immune diversification | J. Exp. Med., Sep 2012; 10.1084/jem.20112145. | shRNA | TR313659 |
| CTSA | Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1 | PLoS Genet. | shRNA | TF501716 |
| CTSL | Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model | Int. J. Cancer | shRNA | TG305172 |
| CUL5 | Cullin 5 is a novel candidate tumor suppressor in renal cell carcinoma involved in the maintenance of genome stability | Oncogenesis | shRNA | TR313638 |
| custom BCL2 | Nicotine increases the resistance of lung cancer cells to cisplatin through enhancing Bcl-2 stability | Br. J. Cancer, Feb 2014. | shRNA | |
| custom OMA1 | Stress-triggered Activation of the Metalloprotease Oma1 Involves its C-terminal Region and is Important for Mitochondrial Stress Protection in Yeast | J. Biol. Chem. | shRNA | |
| custom VPU | The Expression of HIV-1 Vpu in Monocytes Causes Increased Secretion of TGF-β that Activates Profibrogenic Genes in Hepatic Stellate Cells | PLoS ONE, Feb 2014. | shRNA | |
| Cx3cr1 | Emergent role of the fractalkine axis in dissemination of peritoneal metastasis from epithelial ovarian carcinoma | Oncogene | shRNA | TR509718 |
| CXCL10 | Tumor-Suppressive Effects of Natural-type Interferon-ß through CXCL10 in Melanoma | Biochem. Biophys. Res. Commun. | shRNA | TG313633 |
| CXCL12 | CXCL12 secreted from glioma stem cells regulates their proliferation | J. Neurooncol., Jan 2014. | shRNA | TR501994 |
| CXCL17 | The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer. | Biochemical and biophysical research communications | shRNA | TL307883 |
| CXCL8 | A Novel TNF-mediated Mechanism of Direct Epithelial Sodium Channel Activation | Am. J. Respir. Crit. Care Med. July 2014 | shRNA | TG319476 |
| CXCL8 | Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells | Oncotarget July 2014 | shRNA | TG319476 |
| CXCR1 | IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness | Oncotarget | shRNA | TG312158 |
| CXCR2 | IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness | Oncotarget | shRNA | TG312157 |
| CXCR2 | CXCR2 Expression in Tumor Cells Is a Poor Prognostic Factor and Promotes Invasion and Metastasis in Lung Adenocarcinoma | Cancer Res., Jan 2013; 73: 571 - 582. | shRNA | TG312157 |
| CXCR4 | EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma | Nat Commun | shRNA | TR313630 |
| CYBB | Early and Late Events Induced by PolyQ-expanded Proteins: IDENTIFICATION OF A COMMON PATHOGENIC PROPERTY OF POLYQ-EXPANDED PROTEINS | J. Biol. Chem., Feb 2011; 286: 4727 - 4741 | shRNA | TR313616 |
| CYGB | Cytoglobin, the Newest Member of the Globin Family, Functions as a Tumor Suppressor Gene | Cancer Research 68, 7448, September 15, 2008 | shRNA | TR305139 |
| Cyp11a1 | Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8+ T cell skewing in allergic lung disease | PNAS, May 2013; 110: 8152 - 8157. | shRNA | TG500467 |
| CYP19A1 | Brain-synthesized estrogens regulate cortical migration in a sexually divergent manner | BioRxiv | shRNA | TG509276 |
| CYP3A4 | Cytochrome P450 3A5 Plays a Prominent Role in the Oxidative Metabolism of the Anti-Human Immunodeficiency Virus Drug Maraviroc | Drug Metabolism and Disposition | shRNA | TL305124 |
| CYTH1 | A critical role of Arf6 in the response of commissural axons to Slit | Development | shRNA | TR517243 |
| CYTH2 | A critical role of Arf6 in the response of commissural axons to Slit | Development | shRNA | TR501756 |
| CYTH3 | A critical role of Arf6 in the response of commissural axons to Slit | Development | shRNA | TR501757 |
| DAPK1 | Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria | Nat Commun | shRNA | TF504327 |
| DDR1 | Tumor DDR1 deficiency reduces liver metastasis by colon carcinoma and impairs stromal reaction | American journal of physiology. Gastrointestinal and liver physiology | shRNA | TG320280 |
| DDR1 | Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer | Matrix Biology Plus | shRNA | TG320280 |
| DDR2 | Amplification of DDR2 mediates sorafenib resistance through NF-κB/c-Rel signaling in hepatocellular carcinoma | Cell biology international | shRNA | TG320440 |
| DDR2 | DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1 | J. Exp. Clin. Cancer Res. | shRNA | TR320440 |
| DDX56 | Oncogenic splicing abnormalities induced by DEAD-Box Helicase 56 amplification in colorectal cancer | Cancer Sci. | shRNA | TR307148 |
| DDX58 | Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1ß Secretion | J. Virol., Dec 2011; 85: 13019 - 13026. | shRNA | TR313514 |
| DDX6 | The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs | Nucleic Acids Res. | shRNA | TG313512 |
| DEDD | Regulation of the HPV-18 E6/E6AP Ubiquitin Ligase Complex by the HECT domain-containing protein EDD | J. Virol., Jan 2011; 10.1128/JVI.02004-10 | shRNA | TR313510 |
| Depdc5 | DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting | Cell reports | shRNA | TL508165 |
| Depdc5 | DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting | Cell reports | shRNA | TL705799 |
| DEPDC5 | DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons | Neurobiol. Dis. | shRNA | TG508165 |
| DIAPH3 | mDia2 formin selectively interacts with catenins and not E-cadherin to regulate Adherens Junction formation | bioRxiv | shRNA | TG304992 |
| Dicer1 | Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis | Theranostics | shRNA | TL514154 |
| DICER1 | Impaired DICER1 function promotes stemness and metastasis in colon cancer | Oncogene. 2013 Oct 7. | shRNA | TR304991 |
| Dicer1 | Aging-Induced Dysregulation of Dicer1-Dependent MicroRNA Expression Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells | J Gerontol A Biol Sci Med Sci, Aug 2013; 68: 877 - 891. | shRNA | TR304991 |
| DICER1 | Aging-Induced Dysregulation of Dicer1-Dependent MicroRNA Expression Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells | J Gerontol A Biol Sci Med Sci, Dec 2012; 10.1093/gerona/gls242. | shRNA | TG304991 |
| DICER1 | Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells | Clin. Cancer Res., Oct 2011; 17: 6510 - 6521. | shRNA | TR304991 |
| DKK1 | A Positive Feedback Loop Regulates the Expression of Polycomb Group Protein BMI1 via WNT Signaling Pathway | J. Biol. Chem., Feb 2013; 288: 3406 - 3418. | shRNA | TG313465 |
| DKK1 | Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells | Cancer Res., Apr 2009; 69: 3570 - 3578 | shRNA | TR313465 |
| Dkk3 | DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways. | International journal of oncology | shRNA | TL502835 |
| DLAT | Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation | Cell Rep | shRNA | TG507127 |
| DLC1 | Aberrant DNA methylation of alternative promoter of DLC1 isoform 1 in meningiomas | J. Neurooncol | shRNA | TG304982 |
| DLG1 | Differential Regulation of Two Isoforms of the Glial Glutamate Transporter EAAT2 by DLG1 and CaMKII | J. Neurosci. | shRNA | TF313458 |
| DLG4 | Spatial coupling tunes NMDA receptor responses via Ca2+ diffusion | J. Neurosci. | shRNA | TG710382 |
| DLGAP5 | Prognostic value of DLGAP5 in colorectal cancer | Int J Colorectal Dis | shRNA | TG316879 |
| Dll1 | Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells | Elife | shRNA | TG500534 |
| DLL4 | Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replication | World J. Gastroenterol. | shRNA | TG304977 |
| DLL4 | Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7. | Neurobiology of aging | shRNA | TF304977 |
| DLX3 | Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths | Cell Rep | shRNA | TF500537 |
| DLX4 | The Homeoprotein DLX4 Stimulates NF-?B Activation and CD44-Mediated Tumor-Mesothelial Cell Interactions in Ovarian Cancer | Am. J. Pathol. | shRNA | TG313449 |
| DLX4 | Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-ß cytostatic program and blocks the antiproliferative effect of TGF-ß | Oncogene (7 February 2011) doi:10.1038/onc.2011.4 Original Article | shRNA | TR313449 |
| DNAIC2 | Dynein axonemal intermediate chain 2 plays a role in gametogenesis by activation of Stat3 | J. Cell. Mol. Med. | shRNA | TR517468 |
| DNM2 | Bovine Ephemeral Fever Virus Uses a Clathrin-Mediated and Dynamin 2-Dependent Endocytosis Pathway That Requires Rab5 and Rab7 as Well as Microtubules | J. Virol., Dec 2012; 86: 13653 - 13661. | shRNA | TG313406 |
| DNM2 | Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein | J. Biol. Chem., Sep 2011; 286: 30780 - 30794. | shRNA | TG313406 |
| DNMBP | Tuba activates Cdc42 during neuronal polarization downstream of the small GTPase Rab8a | bioRxiv | shRNA | TF515449 |
| DNMT1 | Endoplasmic reticulum protein 29 (ERp29) confers radioresistance through the DNA repair gene, O 6 -methylguanine DNA-methyltransferase, in breast cancer cells | Scientific Reports | shRNA | TF313404 |
| DNMT1 | CD66+ cells in cervical pre-cancers are partially differentiated progenitors with neoplastic traits | Cancer Res. | shRNA | TR313404 |
| DNMT1 | Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein | The Journal of Biological Chemistry | shRNA | TG313404 |
| DNMT3A | Dnmt3a is required for the tumor stemness of B16 melanoma cells | Acta Biochim. Biophys. Sin. (Shanghai) 2019 | shRNA | TF304938 |
| DPYSL2 | A Collapsin Response Mediator Protein 2 Isoform Controls Myosin II-Mediated Cell Migration and Matrix Assembly by Trapping ROCK II | Mol. Cell. Biol., May 2012; 32: 1788 - 1804. | shRNA | TR313374 |
| DSP | Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/ß-catenin signaling pathway in human lung cancer | Carcinogenesis, Aug 2012; 10.1093/carcin/bgs226. | shRNA | TR313354 |
| DUOX2 | Contribution of Dual Oxidase 2 (DUOX2) to Hyper-Radiosensitivity in Human Gastric Cancer Cells | Radiat. Res. | shRNA | TR313350 |
| DUOXA1 | Dual Oxidase Maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation | Cell Commun. Signal, Jan 2014. | shRNA | TR304888 |
| DUSP10 | mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma | Genes Cancer | shRNA | TG304883 |
| Dusp10 | Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML | J. Exp. Med. | shRNA | TG513100 |
| DUSP19 | USP17 regulates Ras activation and cell proliferation by blocking RCE 1 activity | J. Biol. Chem., Feb 2009; 10.1074/jbc.M807216200. | shRNA | TR304880 |
| Dusp2 | Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML | J. Exp. Med. | shRNA | TG514083 |
| DUSP4 | Statins affect ETS1-overexpressing triple-negative breast cancer cells by restoring DUSP4 deficiency | Sci Rep | shRNA | TG304875 |
| Dusp6 | Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML | J. Exp. Med. | shRNA | TG514782 |
| E2F1 | An E2F1/MiR-17-92 Negative Feedback Loop mediates proliferation of Mouse Palatal Mesenchymal Cells | Sci Rep | shRNA | TG509487 |
| E2F1 | Cooperative Activation of Tissue-Specific Genes by pRB and E2F1 | Cancer Res., Apr 2013; 73: 2150 - 2158. | shRNA | TG320325 |
| E2F1 | Transcriptional Regulation of the Human Tumor Suppressor DOK1 by E2F1 | Mol. Cell. Biol., Dec 2012; 32: 4877 - 4890. | shRNA | TG320325 |
| E2F6 | A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members | Genome Res. 2007 Nov;17(11):1550-61. | shRNA | TR316522 |
| EDD | Regulation of the Human Papillomavirus Type 18 E6/E6AP Ubiquitin Ligase Complex by the HECT Domain-Containing Protein EDD | J. Virol., Apr 2011; 85: 3120 - 3127 | shRNA | |
| EDEM1 | Innate Sensing of Influenza A Virus Hemagglutinin Glycoproteins by the Host Endoplasmic Reticulum (ER) Stress Pathway Triggers a Potent Antiviral Response via ER-Associated Protein Degradation | Journal of Virology | shRNA | TL313302 |
| EGFP | The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability | Nucleic Acids Res. | shRNA | TR30001 |
| EGFR | Expression level of EGFR and MET receptors regulates invasiveness of melanoma cells | J. Cell. Mol. Med. | shRNA | TG320326 |
| EGFR | Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers | Cell Stem Cell | shRNA | TR509941 |
| EGFR | Modification of cytokine-induced killer cells with chimeric antigen receptors (CARs) enhances antitumor immunity to epidermal growth factor receptor (EGFR)-positive malignancies | Cancer Immunol. Immunother. | shRNA | TG320326 |
| EGFR | EGFR signaling defines Mcl(-)1 survival dependency in neuroblastoma | Cancer Biol. Ther. | shRNA | TG320326 |
| EGFR | Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development | J. Biol. Chem. | shRNA | TG320326 |
| EGFR | Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cells | PNAS. published 10 December 2008, 10.1073/pnas.0804723105 | shRNA | TR320326 |
| EGFR | Polyethylene glycol-mediated colorectal cancer chemoprevention: roles of epidermal growth factor receptor and Snail | Mol. Cancer Ther., Sep 2008; 7: 3103 - 3111 | shRNA | TR320326 |
| EGR3 | Opposing role for egr3 in nucleus accumbens cell subtypes in cocaine action | J. Neurosci. | shRNA | TG500585 |
| Ehmt2 | Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors | Stem Cells International May 2015 | shRNA | TG505922 |
| EIF2AK2 | Identification of the PKR Nuclear Interactome Reveals Roles in Ribosome Biogenesis, mRNA Processing and Cell Division | J. Cell. Physiol. Dec 2013. | shRNA | TG320493 |
| Eif2ak4 | Genetic or Pharmacological Reduction of PERK Enhances Cortical-Dependent Taste Learning | J. Neurosci. | shRNA | TG511649 |
| EIF4A1 | miR-133a acts as a tumor suppressor in colorectal cancer by targeting eIF4A1 | Tumour Biol. | shRNA | TG313247 |
| ELAVL1 | The alternative spliced 3'-UTR mediated differential secretion of macrophage colony stimulating factor in breast cancer cells | Biochem. Biophys. Res. Commun. | shRNA | TR313235 |
| ELAVL1 | Posttranscriptional Suppression of Proto-Oncogene c-fms Expression by Vigilin in Breast Cancer | Mol. Cell. Biol., Jan 2011; 31: 215 - 225 | shRNA | TR313235 |
| ELAVL1 | Post-Transcriptional Suppression of Proto-Oncogene c-fms Expression by Vigilin in Breast Cancer | Mol. Cell. Biol., Oct 2010; 10.1128/MCB.01031-10 | shRNA | TR313235 |
| ELAVL1 | Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer | Oncogene (19 Jan 2009), doi: 10.1038/onc.2008.469 | shRNA | TR313235 |
| ELAVL4 | Prenatal Deletion of the RNA-Binding Protein HuD Disrupts Postnatal Cortical Circuit Maturation and Behavior | J. Neurosci. | shRNA | TG501025 |
| ELAVL4 | The role of HuD, a post-transcriptional regulator, in the development and function of the murine neocortex | Thesis. January 2014 | shRNA | TG501025 |
| ELF3 | A transcriptional repressive role for epithelial-specific ETS factor ELF3 on estrogen receptor-alpha in breast cancer cells | BIOCHEMICAL JOURNAL | shRNA | TG313232 |
| ELK1 | GADD45a-Targeted Suicide Gene Therapy for the Prevention or Treatment of Non-Small Cell Lung Carcinoma | Thesis | shRNA | TR320328 |
| ELMO1 | A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis | Nat. Immunol. | shRNA | TG320622 |
| EMILIN1 | EMILIN1–a4/a9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation | J. Cell Biol., Sep 2011; 10.1083/jcb.201008013. | shRNA | TR510314 |
| EMX2 | EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas | PLoS ONE | shRNA | TF313216 |
| EMX2 | EMX2 is epigenetically silenced and suppresses growth in human lung cancer | Oncogene (9 August 2010) doi:10.1038/onc.2010.330 Short Communication | shRNA | TR313216 |
| ENPP1 | Antagonistic interactions between osterix and pyrophosphate during cementum formation | Bone | shRNA | TG501613 |
| Entpd1 | cAMP/CREB-mediated Transcriptional Regulation of Ectonucleoside Triphosphate Diphosphohydrolase 1 (CD39) Expression | J. Biol. Chem., May 2010; 285: 14791 - 14805 | shRNA | TR500312 |
| EP300 | Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells through Destabilizing AKT | Int. J. Biol. Sci. | shRNA | TG313197 |
| EP300 | ANALYSIS OF THE UPSTREAM SIGNALLING PATHWAY CONTROLLING DELTANP63ALPHA PROTEIN STABILITY AND FUNCTION | Thesis | shRNA | TR313197 |
| EPAS1 | Modulation of the mevalonate pathway by Akt regulates macrophage survival and development of pulmonary fibrosis | J. Biol. Chem. | shRNA | TG315484 |
| EPHA2 | Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer | Matrix Biol. | shRNA | TR320327 |
| EPHA2 | EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma | Int. J. Cancer | shRNA | TR320327 |
| EPHA2 | A Modified Adenovirus Vector-Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target | Transl Oncol | shRNA | TR320327 |
| EPHA2 | A Genome-Wide Screen Reveals Functional Gene Clusters in the Cancer Genome and Identifies EphA2 as a Mitogen in Glioblastoma | Cancer Res., Nov 2006; 66: 10815-10823. | shRNA | TR320327 |
| EPHB2 | Effects of Toxicologically Relevant Xenobiotics and the Lipid-Derived Electrophile 4-Hydroxynonenal on Macrophage Cholesterol Efflux: Silencing Carboxylesterase 1 Has Paradoxical Effects on Cholesterol Uptake and Efflux | Chem. Res. Toxicol. | shRNA | TG320337 |
| EPHB4 | Erythropoietin Promotes Bone Formation through EphrinB2/EphB4 Signaling | J. Dent. Res. | shRNA | TG500619 |
| EPHX2 | Pro-Resolving Maresins in Inflammation: New Pathway and Mechanisms With Oral Pathogens | Thesis | shRNA | TR313191 |
| EPHX2 | Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages | PLoS ONE July 2014 | shRNA | TR313191 |
| ERAP1 | ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface | Mol. Immunol. | shRNA | TG307017 |
| ERBB3 | A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations | Proteomics | shRNA | TR320343 |
| ERBB3 | microRNA-205 Regulates HER3 in Human Breast Cancer | Cancer Res., Mar 2009; 69: 2195 - 2200 | shRNA | TR320343 |
| ERCC6 | Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane | FASEB J, Feb 2010; 10.1096/fj.09-147991 | shRNA | TR313176 |
| ERCC6 | Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase | J. Biol. Chem., Jan 2009; 10.1074/jbc.M807006200. | shRNA | TR313176 |
| ERN1 | Insulin demand regulates ß cell number via the unfolded protein response | J. Clin. Invest. | shRNA | TG320345 |
| ERO1A | Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer | Oncotarget | shRNA | TR313168 |
| ERO1a | Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-a-mediated oxidative folding in murine tumor cells | Eur. J. Immunol. | shRNA | TR502816 |
| ERO1A | Cancer-associated oxidoreductase ERO1-a drives the production of VEGF via oxidative protein folding and regulating the mRNA level | Br. J. Cancer | shRNA | TR313168 |
| ERO1A | Cancer-Associated Oxidase ERO1-a Regulates the Expression of MHC Class I Molecule via Oxidative Folding | J. Immunol. | shRNA | TR313168 |
| Ero1a | Cancer-associated oxidoreductase ERO1-α drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding. | Journal of immunology (Baltimore, Md. : 1950) | shRNA | TR502816 |
| ERO1A | Real-time monitoring of redox changes in the mammalian endoplasmic reticulum | J. Cell Sci., Jul 2011; 124: 2349 - 2356. | shRNA | TR313168 |
| ERRFI1 | The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations | Oncogene | shRNA | TR304737 |
| ESR1 | Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer | Oncogene | shRNA | TR320346 |
| ESR1 | RIZ1 is regulated by estrogen and suppresses tumor progression in endometrial cancer | Biochem. Biophys. Res. Commun. | shRNA | TR320346 |
| ESR1 | Knockdown of estrogen receptor-a induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death | FASEB J. | shRNA | TR320346 |
| ESR1 | Nuclear Localization of the Transcriptional Regulator MIER1a Requires Interaction with HDAC1/2 in Breast Cancer Cells | PLoS ONE Dec 2013. | shRNA | TG320346 |
| ESR2 | Expression of Estrogen Receptor Beta Predicts Oncologic Outcome of pT3 Upper Urinary Tract Urothelial Carcinoma Better Than Aggressive Pathological Features | Sci Rep | shRNA | TG320347 |
| ESR2 | Biologic Roles of Estrogen Receptor-ß and Insulin-Like Growth Factor-2 in Triple-Negative Breast Cancer | BioMed Research International | shRNA | TG320347 |
| Esrrg | Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERR{gamma} | Nucleic Acids Res., Oct 2008; 36: 5727 - 5735. | shRNA | TR502584 |
| Esrrg | Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERR | Nucleic Acids Res., Sep 2008; 10.1093/nar/gkn567. | shRNA | TR502584 |
| Esrrg | Orphan nuclear receptor estrogen-related receptor-? suppresses in vitro and in vivo growth of prostate cancer cells via p21WAF1/CIP1 induction and as a potential therapeutic target in prostate cancer | Oncogene 27, 3313 - 3328 (10 Dec 2007) | shRNA | TR502584 |
| ETS1 | ETS1 transcriptional activity is increased in advanced prostate cancer and promotes the castrate-resistant phenotype | Carcinogenesis, Mar 2012; 33: 572 - 580. | shRNA | TR313153 |
| ETS2 | Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion | The EMBO Journal | shRNA | TG320351 |
| ETS2 | Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion | The EMBO Journal doi:10.1038/emboj.2012.153 | shRNA | TR320351 |
| Etv4 | Pea3 Expression Promotes the Invasive and Metastatic Potential of Colorectal Carcinoma | World Journal of Gastroenterology July 2014 | shRNA | TG509137 |
| EWSR1 | Ewing sarcoma breakpoint region 1 prevents transcription-associated genome instability | bioRxiv Dec2015 | shRNA | TG313142 |
| EXO1 | Phospholipase C-ε regulates bladder cancer cells via ATM/EXO1 | American journal of cancer research | shRNA | TR304725 |
| Exoc4 | CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion | Stem Cells | shRNA | TR502000 |
| EXTL3 | Regenerating Islet-derived 1a (Reg-1a) Protein Is New Neuronal Secreted Factor That Stimulates Neurite Outgrowth via Exostosin Tumor-like 3 (EXTL3) Receptor | J. Biol. Chem., Feb 2012; 287: 4726 - 4739. | shRNA | TG313126 |
| EYA1 | EYA1's conformation-specificity in dephosphorylating phosphothreonine in Myc and its activity on Myc stabilization in breast cancer | Mol. Cell. Biol. | shRNA | TR304716 |
| EYA1 | Regulation of the innate immune response by threonine-phosphatase of Eyes absent | Nature. 2009 Jul 23;460(7254):520-4. | shRNA | TR304716 |
| EYA2 | Regulation of the innate immune response by threonine-phosphatase of Eyes absent | Nature. 2009 Jul 23;460(7254):520-4. | shRNA | TR304715 |
| EYA3 | Regulation of the innate immune response by threonine-phosphatase of Eyes absent | Nature. 2009 Jul 23;460(7254):520-4. | shRNA | TR316534 |
| EYA4 | Regulation of the innate immune response by threonine-phosphatase of Eyes absent | Nature. 2009 Jul 23;460(7254):520-4. | shRNA | TR304714 |
| EZH2 | Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma | The Journal of Clinical Investigation | shRNA | TL304713 |
| EZH2 | Maternal regulation of SATB2 in osteo‐progeniters impairs skeletal development in offspring | FASEB j. | shRNA | TG509722 |
| EZH2 | EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma | Nat Commun | shRNA | TR304713 |
| EZH2 | C-type lectin-like domain and fibronectin-like type II domain of phospholipase A2 receptor 1 modulate binding and migratory responses to collagen | FEBS Lett. | shRNA | TG304713 |
| Ezh2 | NFIB-Mediated Repression of the Epigenetic Factor Ezh2 Regulates Cortical Development | J. Neurosci., Feb 2014. | shRNA | TF304713 |
| EZH2 | EZH2/miR-30d/KPNB1 pathway regulates malignant peripheral nerve sheath tumor cell survival and tumorigenesis | J Pathol. 2013 Oct 16 | shRNA | TG304713 |
| EZH2 | GATA-1 Utilizes Ikaros and Polycomb Repressive Complex 2 To Suppress Hes1 and To Promote Erythropoiesis | Mol. Cell. Biol., Sep 2012; 32: 3624 - 3638. | shRNA | TR304713 |
| F11r | Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury | Neurobiol. Dis. | shRNA | TG501134 |
| FABP5 | Role of Fatty Acid Binding Protein 5 (FABP5) in Breast Cancer Progression and Metastasis | Thesis | shRNA | TG316535 |
| FADD | RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy | Autophagy | shRNA | TG320593 |
| FADS1 | Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD + Recycling | Cell metabolism | shRNA | TR313102 |
| FADS2 | Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD + Recycling | Cell metabolism | shRNA | TR313101 |
| Faf2 | A Ubiquitin-like Domain Recruits an Oligomeric Chaperone to a Retrotranslocation Complex in Endoplasmic Reticulum-associated Degradation | J. Biol. Chem., Jun 2013; 288: 18068 - 18076. | shRNA | TG509324 |
| FAF2 | Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets | Mol. Biol. Cell, Mar 2012; 23: 800 - 810. | shRNA | TR308511 |
| FAIM2 | Lifeguard inhibition of Fas-mediated apoptosis: A possible mechanism for explaining the cisplatin resistance of triple-negative breast cancer cells | Biomed. Pharmacother. | shRNA | TG313099 |
| FAM107A | Down-regulated in renal cell carcinoma 1 (DRR1) regulates axon outgrowth during hippocampal neuron development | Biochemical and biophysical research communications | shRNA | TG702872 |
| FANCA | Upregulated ATM Gene Expression and Activated DNA Crosslink–Induced Damage Response Checkpoint in Fanconi Anemia: Implications for Carcinogenesis | Mol Med 14 (3-4) 167-174 | shRNA | TR313071 |
| FANCA | Ataxia Telangiectasia Mutated (ATM) Gene Expression Is Reversibly Up-Regulated in FANCA-Mutant Patient Fibroblasts by an Indirect Mechanism | Blood (ASH Annual Meeting Abstracts), Nov 2007; 110: 1679. | shRNA | TR313071 |
| FANCD2 | HPV-16 E7 Reveals a Link between DNA Replication Stress, Fanconi Anemia D2 Protein, and Alternative Lengthening of Telomere–Associated Promyelocytic Leukemia Bodies | Cancer Res., Dec 2008; 68: 9954 - 9963. | shRNA | TR313068 |
| FANCF | F-box and leucine-rich repeat protein 5 promotes colon cancer progression by modulating PTEN/PI3K/AKT signaling pathway. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | shRNA | TF304585 |
| FASN | Up-Regulated FASN Expression Promotes Transcoelomic Metastasis of Ovarian Cancer Cell through Epithelial-Mesenchymal Transition | Int J Mol Sci July 2014 | shRNA | TR313058 |
| FBXL5 | F-box and leucine-rich repeat protein 5 promotes colon cancer progression by modulating PTEN/PI3K/AKT signaling pathway | Biomed. Pharmacother. | shRNA | TF304567 |
| FBXO28 | LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1 | J. Cell. Sci. | shRNA | TG313036 |
| Fbxo46 | The SCF FBXO46 ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence | The Journal of Biological Chemistry | shRNA | TL702960 |
| FCN1 | Secreted M-Ficolin Anchors onto Monocyte Transmembrane G Protein-Coupled Receptor 43 and Cross Talks with Plasma C-Reactive Protein to Mediate Immune Signaling and Regulate Host Defense | J. Immunol., Dec 2010; 185: 6899 - 6910 | shRNA | TR313015 |
| FCRL1 | Fc Receptor-Like 1 as a Promising Target for Immunotherapeutic Interventions of B-Cell-Related Disorders | Biomark Insights. | shRNA | TG304533 |
| FDX1 | Mitochondrial Targeting of Cytochrome P450 (CYP) 1B1 and its Role in Polycyclic Aromatic Hydrocarbon-Induced Mitochondrial Dysfunction | J. Biol. Chem., Feb 2014. | shRNA | TG313008 |
| FFAR1 | Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells | J. Recept. Signal Transduct. Res. | shRNA | TR313001 |
| FFAR1 | Induction of GPR40 positively regulates cell motile and growth activities in breast cancer MCF-7 cells | J. Recept. Signal Transduct. Res. | shRNA | TR313001 |
| FFAR1 | Involvement of FFA1 and FFA4 in the regulation of cellular functions during tumor progression in colon cancer cells | Exp. Cell Res. | shRNA | TF313001 |
| FFAR1 | Diverse effects of G-protein-coupled free fatty acid receptors on the regulation of cellular functions in lung cancer cells | Exp. Cell Res. | shRNA | TR313001 |
| FFAR1 | Negative effects of G-protein-coupled free fatty acid receptor GPR40 on cell migration and invasion in fibrosarcoma HT1080 cells | Mol. Carcinog. | shRNA | TR313001 |
| FFAR1 | Different roles of GPR120 and GPR40 in the acquisition of malignant properties in pancreatic cancer cells | Biochem. Biophys. Res. Commun. | shRNA | TR313001 |
| FFAR2 | Dysregulated Free Fatty Acid Receptor 2 Exacerbates Colonic Adenoma Formation in Apc\n Min/+\n Mice: Relation to Metabolism and Gut Microbiota Composition | Journal of cancer prevention | shRNA | TR313000 |
| FFAR2 | Free fatty acids receptors 2 and 3 control cell proliferation by regulating cellular glucose uptake | World J Gastrointest Oncol | shRNA | TR313000 |
| FFAR4 | Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells | J. Recept. Signal Transduct. Res. | shRNA | TF307824 |
| FFAR4 | Involvement of FFA1 and FFA4 in the regulation of cellular functions during tumor progression in colon cancer cells | Exp. Cell Res. | shRNA | TF307824 |
| FFAR4 | Different effects of G-protein-coupled receptor 120 (GPR120) and GPR40 on cell motile activity of highly migratory osteosarcoma cells | Biochem. Biophys. Res. Commun | shRNA | TR307824 |
| FFAR4 | Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells | Biochem. Biophys. Res. Commun. | shRNA | TF307824 |
| FFAR4 | Different roles of GPR120 and GPR40 in the acquisition of malignant properties in pancreatic cancer cells | Biochem. Biophys. Res. Commun. | shRNA | TF307824 |
| Ffar4 | Opposite effects of GPR120 and GPR40 on cell motile activity induced by ethionine in liver epithelial cells | Biochem. Biophys. Res. Commun. | shRNA | TG703763 |
| Ffar4 | Role of GPR120 in cell motile activity induced by 12-O-tetradecanoylphorbol-13-acetate in liver epithelial WB-F344 cells | Mol. Cell. Biochem. | shRNA | TG703763 |
| FGF2 | Oct4-dependent FoxC1 Activation Improves the Survival and Neovascularization of Mesenchymal Stem Cells under Myocardial Ischemia | Research Square | shRNA | TR710311 |
| FGF7 | Regulation of Epithelial Differentiation and Proliferation by the Stroma: A Role for the Retinoblastoma Protein | Journal of Investigative Dermatology doi:10.1038/jid.2012.201 | shRNA | TR312988 |
| FGFR1 | FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their co-expression may predict FGFR-targeted therapy efficacy | EBioMedicine | shRNA | TF320354 |
| FGFR2 | Neutralizing antibody to FGFR2 can act as a selective biomarker and potential therapeutic agent for gastric cancer with FGFR2 amplification | Am J Transl Res | shRNA | TG318702 |
| FGFR4 | FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their co-expression may predict FGFR-targeted therapy efficacy | EBioMedicine | shRNA | TR320356 |
| FGFR4 | FGFR4 increases EGFR oncogenic signaling in lung adenocarcinoma, and their combined inhibition is highly effective | Lung Cancer | shRNA | TR320356 |
| Fhl2 | FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply | The Journal of Cell Biology | shRNA | TL711478 |
| FIGNL1 | FIGNL1 is overexpressed in small cell lung cancer patients and enhances NCI-H446 cell resistance to cisplatin and etoposide | Oncol. Rep. | shRNA | TR304505 |
| FKBP2 | The Function of FK506-Binding Protein 13 in Protein Quality Control Protects Plasma Cells from Endoplasmic Reticulum Stress-Associated Apoptosis | Front Immunol | shRNA | TG500710 |
| FKBP3 | The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability | Nucleic Acids Res. | shRNA | TR319727 |
| FLT1 | Autocrine VEGF signaling promotes cell proliferation and modulates the sorafenib treatment efficacy in hepatocellular carcinoma | Hepatology | shRNA | TG320360 |
| Flt1 | miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1 | Mol. Cancer Res., Jan 2011; 9: 25 - 35 | shRNA | TG514364 |
| FLT4 | Neuropilin-2 mediates lymphangiogenesis of colorectal carcinoma via a VEGFC/VEGFR3 independent signaling | Cancer Lett. | shRNA | TG320362 |
| FN1 | Cellular fibronectin 1 promotes VEGF-C expression, lymphangiogenesis and lymph node metastasis associated with human oral squamous cell carcinoma | Clin. Exp. Metastasis | shRNA | TR304489 |
| Fnbp1 | Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning | Dev. Cell2017 | shRNA | TF712968 |
| FNBP1 | Collective membrane dynamics emerging from curvature-dependent spatial coupling | bioRxiv | shRNA | TG712968 |
| FOLR1 | Modification of cytokine-induced killer cells with folate receptor alpha (FRα)-specific chimeric antigen receptors enhances their antitumor immunity toward FRα-positive ovarian cancers | Mol. Immunol. | shRNA | TR304479 |
| FOLR1 | Folate Receptor Alpha Upregulates Oct4, Sox2 and Klf4 and Downregulates miR-138 and miR-let-7 in Cranial Neural Crest Cells | Stem Cells | shRNA | TG304479 |
| FOS | GLP2 Promotes Directed Differentiation from Osteosarcoma Cells to Osteoblasts and Inhibits Growth of Osteosarcoma Cells | Mol Ther Nucleic Acids | shRNA | TG312946 |
| FOS | Glucagon-like peptide 2 promotes directed-differentiation from osteosarcoma cells to osteoblast and inhibits growth of osteosarcoma cells | Molecular Therapy-Nucleic Acids | shRNA | TG312946 |
| FOSB | Activation of the Transcription Factor FosB/Activating Protein-1 (AP-1) Is a Prominent Downstream Signal of the Extracellular Nucleotide Receptor P2RX7 in Monocytic and Osteoblastic Cells | J. Biol. Chem., Oct 2010; 285: 34288 - 34298 | shRNA | TR312945 |
| Fox-3 | Identification of Neuronal Nuclei (Neun) As Fox-3, a new member of the Fox-1 gene family of splicing factors | JBC Papers doi: 10.1074/jbc.M109.052969 | shRNA | |
| FOXA1 | Forkhead box protein A1 is a prognostic predictor and promotes tumor growth of gastric cancer | Onco Targets Ther | shRNA | TR312942 |
| FOXD3 | FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway | Oncotarget | shRNA | TR312939 |
| FOXD3 | Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia | PNAS, Aug 2009; 106: 13433 - 13438 | shRNA | TR312939 |
| FOXK1 | FOXK1 and FOXK2 regulate aerobic glycolysis | Nature | shRNA | TR501358 |
| FOXK2 | FOXK1 and FOXK2 regulate aerobic glycolysis | Nature | shRNA | TR517739 |
| FOXO3 | β-amyloid-induced gonadotropin-releasing hormone decline involving Forkhead transcription factor FOXO3a and nuclear factor-κB | Neuroreport | shRNA | TR320359 |
| FOXO3 | Regulation of the Tumor Suppressor FOXO3 by the Thromboxane-A2 Receptors in Urothelial Cancer | PLoS ONE | shRNA | TF320359 |
| FOXO3 | Reprogramming ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through FOXO3 activation | Sci Rep July 2014 | shRNA | TR320359 |
| FOXO3 | AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt-MDM2-Foxo3a Signaling Axis | Cancer Res. July 2014 | shRNA | TR320359 |
| FOXO3 | Role of TRPM2 in cell proliferation and susceptibility to oxidative stress | Am J Physiol Cell Physiol, Mar 2013; 304: C548 - C560. | shRNA | TG320359 |
| FOXP1 | FOXP1 is a key regulator of quiescence in healthy human CD3(+) CD4(+) T Cells and is constitutively repressed in CD3(-) CD4(+) T cells from patients with lymphoproliferative disorders | Eur. J. Immunol. | shRNA | TR304471 |
| FOXP3 | Forkhead box P3 regulates ARHGAP15 expression and affects migration of glioma cells through the Rac1 signaling pathway | Cancer Sci | shRNA | TF317157 |
| FOXP3 | Endogenous FOXP3 inhibits cell proliferation, migration and invasion in glioma cells | Int J Clin Exp Med | shRNA | TF317157 |
| FRK | Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways | PLoS ONE | shRNA | TG517143 |
| FRMPD2 | PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells | J. Cell Sci., Aug 2009; 10.1242/jcs.046854 | shRNA | TR312922 |
| fscn2 | Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells | Toxicol. Lett | shRNA | TG705644 |
| Fundc1 | A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy | Redox Biology | shRNA | TR702819 |
| FURIN | Overexpression of the pro‐protein convertase furin predicts prognosis and promotes papillary thyroid carcinoma progression and metastasis through RAF / MEK signaling | Molecular Oncology | shRNA | TR312903 |
| FURIN | Human α-L-fucosidase-1 attenuates the invasive properties of thyroid cancer | Oncotarget | shRNA | TG312903 |
| Furin | Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing | PLoS ONE, Jan 2014. | shRNA | TF312903 |
| FUT4 | Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis | J. Neurooncol. | shRNA | TG312897 |
| FUT7 | Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis | J. Neurooncol. | shRNA | TG312894 |
| FYCO1 | The role of FYCO1-dependent autophagy in lens fiber cell differentiation. | Autophagy | shRNA | TL304437 |
| FZD10 | FZD10 regulates cell proliferation and mediates Wnt1 induced neurogenesis in the developing spinal cord | BioRxiv | shRNA | TF312885 |
| FZD2 | Suppression of hepatocellular carcinoma cell proliferation by short hairpin RNA of frizzled 2 with Sonazoid-enhanced irradiation | Int. J. Oncol. | shRNA | TR312884 |
| FZD2 | Gastric cancer cell proliferation is suppressed by frizzled-2 short hairpin RNA | Int. J. Oncol. | shRNA | TR312884 |
| FZD2 | Short hairpin RNA of frizzled-2 suppresses the proliferation of hepatocellular carcinoma cells | ONCOLOGY LETTERS | shRNA | TR312884 |
| FZD2 | Frizzled-2: A potential novel target for molecular pancreatic cancer therapy | Oncology Letters 74 | shRNA | TR312884 |
| FZD2 | Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras–Mutated Colorectal Cancer | Mol. Cancer Ther., Dec 2010; 9: 3351 - 3362 | shRNA | TR312884 |
| FZD5 | Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis | Angiogenesis | shRNA | TG312882 |
| FZD7 | Extrinsic Regulators of mRNA Translation in Developing Brain: Story of WNTs | Cells | shRNA | TG500742 |
| G3bp1 | GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy | PLoS ONE | shRNA | TL515376 |
| GABPA | Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas. | Molecular cell | shRNA | TL312871 |
| Galm | Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series | Genome Med | shRNA | TG700891 |
| GAS2 | The Interferon Consensus Sequence Binding Protein (ICSBP) Decreases Bcatenin-Activity in Myeloid Cells By Repressing GAS2 Transcription | Mol. Cell. Biol., Oct 2010; 30: 4575 - 4594 | shRNA | TR511218 |
| Gata3 | Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity | Journal for Immunotherapy of Cancer | shRNA | TL513036 |
| GATA4 | GATA-4 upregulates glucose-dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage | Mol Cell Endocrinol. 2008 June 11; 287(1-2): 20–29 | shRNA | TR500773 |
| GB200002 | DAB2IP regulates cancer stem cell phenotypes through modulating stem cell factor receptor and ZEB1 | Oncogene July 2014 | shRNA | HC121827 |
| GBP5 | GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. | Science (New York, N.Y.) | shRNA | TG304384 |
| GCLC | EPITHELIAL AND MESENCHYMAL CELL BIOLOGY: Endogenous Hydrogen Peroxide Regulates Glutathione Redox via Nuclear Factor Erythroid 2-Related Factor 2 Downstream of Phosphatidylinositol 3-Kinase during Muscle Differentiation | Am. J. Pathol., Jun 2008; 172: 1529 - 1541. | shRNA | TR312813 |
| GDF15 | Hypoxia Induces Growth Differentiation Factor 15 to Promote the Metastasis of Colorectal Cancer via PERK-eIF2α Signaling | BioMed Research International | shRNA | TR312802 |
| GFP | PKR Regulates B56{alpha}-mediated BCL2 Phosphatase Activity in Acute Lymphoblastic Leukemia-derived REH Cells | J. Biol. Chem., Dec 2008; 283: 35474 - 35485. | shRNA | |
| GFP-tagged siRNA | Motoneurons Secrete Angiogenin to Induce RNA Cleavage in Astroglia | J. Neurosci., Apr 2012; 32: 5024 - 5038. | shRNA | |
| GHITM | TMBIM5 is the Ca 2+ /H + antiporter of mammalian mitochondria | EMBO Reports | shRNA | TR315671 |
| GHR | Growth hormone receptor (GHR) promotes breast cancer progression via the BRAF/MEK/ERK signaling pathway | FEBS Open Bio | shRNA | TR312779 |
| GHR | Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2 | Exp. Mol. Med. | shRNA | TR312779 |
| Ghrl | Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages. | Biochemical and biophysical research communications | shRNA | TL503386 |
| GHSR | The suppression of ghrelin signaling mitigates age-associated thermogenic impairment | Aging (Albany NY) | shRNA | TG506242 |
| GINS4 | Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia | JCI Insight | shRNA | TL304343 |
| GJA1 | Specific N-cadherin-dependent pathways drive human breast cancer dormancy in bone marrow | Life science alliance | shRNA | TF312771 |
| GJA1 | Connexin hemichannel and pannexin channel electrophysiology: How do they differ? | FEBS Lett., Jan 2014. | shRNA | TR312771 |
| GJA1 | Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: Role of Beta-catenin/connexin43 association | Exp Cell Res. 2013 Dec 10;319(20):3065-80 | shRNA | TR312771 |
| GJA1 | Gap Junctions/Hemichannels Modulate Interkinetic Nuclear Migration in the Forebrain Precursors | J. Neurosci., Mar 2010; 30: 4197 - 4209 | shRNA | TR500808 |
| GJB2 | Gap junction β‑2 expression is negatively associated with the estrogen receptor status in breast cancer tissues and is a regulator of breast tumorigenesis | Oncol Rep | shRNA | TR312766 |
| GLI1 | Modulation of the IL-6 Receptor a Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells | J. Immunol. | shRNA | TG312756 |
| GLI1 | Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells | Cancer Res., Feb 2011; 71: 1092 - 1102 | shRNA | TR312756 |
| GLI2 | Novel Molecular Mechanism of Regulation of CD40 Ligand by the Transcription Factor GLI2 | J. Immunol. | shRNA | TR312755 |
| GLI2 | Hedgehog and TGFß signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma | Oncotarget | shRNA | TR312755 |
| GLI2 | Modulation of the IL-6 Receptor a Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells | J. Immunol. | shRNA | TG312755 |
| GLI2 | Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells | Cancer Res., Feb 2011; 71: 1092 - 1102 | shRNA | TR312755 |
| GOLGA2 | GOLGA2/GM130, cis-Golgi Matrix Protein, is a Novel Target of Anticancer Gene Therapy | Molecular Therapy doi:10.1038/mt.2012.125 | shRNA | TR312706 |
| GOT1 | Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-ß/Smad pathway in vascular smooth muscle cells | Sci Rep | shRNA | TF709215 |
| Got1 | Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling | Cell Death Dis | shRNA | TF709215 |
| GOT2 | Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-ß/Smad pathway in vascular smooth muscle cells | Sci Rep | shRNA | TF709767 |
| Got2 | Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling | Cell Death Dis | shRNA | TF709767 |
| GPAT3 | GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis | J. Lipid Res., Jul 2010; 51: 1971 - 1981 | shRNA | TR307398 |
| GPAT4 | GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis | J. Lipid Res., Jul 2010; 51: 1971 - 1981 | shRNA | TR306795 |
| Gpbar1 | The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis. | Journal of immunology (Baltimore, Md. : 1950) | shRNA | TG506766 |
| GPER1 | Stabilization of MORC2 by estrogen and antiestrogens through GPER1- PRKACA-CMA pathway contributes to estrogen-induced proliferation and endocrine resistance of breast cancer cells | Autophagy | shRNA | TG316565 |
| GPER1 | Estrogenic transmembrane receptor of GPR30 mediates invasion and carcinogenesis by endometrial cancer cell line RL95-2. | Journal of cancer research and clinical oncology | shRNA | TG316565 |
| GPER1 | The G protein-coupled receptor GPR30 mediates the proliferative and invasive effects induced by hydroxytamoxifen in endometrial cancer cells. | Biochemical and biophysical research communications | shRNA | TG316565 |
| GPER1 | Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ERK mitogen-activated protein kinase pathway. | Cancer science | shRNA | TG316565 |
| GPNMB | The Potential Role of the Glycoprotein Osteoactivin/Glycoprotein Nonmetastatic Melanoma Protein B in Pancreatic Cancer | Pancreas | shRNA | TG312675 |
| Gpr119 | Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol | Nature Communications | shRNA | TL507165 |
| GPR132 | Serum-borne lipids amplify TLR-activated inflammatory responses | J. Leukoc. Biol. | shRNA | TG312669 |
| GPR68 | Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H | Proc. Natl. Acad. Sci. U.S.A. | shRNA | TF507234 |
| GPSM1 | G Protein-Coupled Receptor Kinase-6 Interacts with Activator of G Protein Signaling-3 To Regulate CXCR2-Mediated Cellular Functions | J. Immunol., Feb 2014. | shRNA | TG713072 |
| Gpx4 | Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy. | Cell metabolism | shRNA | TL508967 |
| GPX4 | Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy. | Cell metabolism | shRNA | TR316568 |
| GPX4 | DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer | Nature | shRNA | TR316568 |
| GREM1 | The bone morphogenetic protein antagonist Gremlin is overexpressed in human malignant mesothelioma. | Oncology reports | shRNA | TR312620 |
| GRHL1 | EGFR-ERK induced activation of GRHL1 promotes cell cycle progression by up-regulating cell cycle related genes in lung cancer | Cell death & disease | shRNA | TR304207 |
| GRM1 | GRM1 is An Androgen-Regulated Gene and its Expression Correlates with Prostate Cancer Progression in Pre-Clinical Models | Clin. Cancer Res. | shRNA | RG214400 |
| GRN | The perlecan-interacting growth factor progranulin regulates ubiquitination, sorting, and lysosomal degradation of sortilin | Matrix Biol. | shRNA | TR312595 |
| GRN | Sortilin regulates progranulin action in castration-resistant prostate cancer cells | Endocrinology | shRNA | TR312595 |
| GRN | Proepithelin is an autocrine growth factor for bladder cancer | Carcinogenesis, May 2009; 30: 861 - 868. | shRNA | TR312595 |
| GSK3A | Selectively Silencing GSK-3 Isoforms Reduces Plaques and Tangles in Mouse Models of Alzheimer's Disease | J. Neurosci., May 2012; 32: 7392 - 7402. | shRNA | TR320375 |
| GSTM4 | Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages | Proc. Natl. Acad. Sci. U.S.A. | shRNA | TR304180 |
| GSTP1 | Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells | J. Cell. Physiol. | shRNA | TG709221 |
| GSTT2 | GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage | Molecular Nutrition & Food Research Volume 53 Issue 10, Pages 1245 - 1253 | shRNA | TR312581 |
| GTF2I | DNA damage response defect in Williams-Beuren syndrome | Int. J. Mol. Med. | shRNA | TG304176 |
| GTF2I | PLA2G16 represents a switch between entry and clearance of Picornaviridae | Nature | shRNA | TG304176 |
| Gucy1b1 | The β subunit of soluble guanylyl cyclase GUCY1B3 exerts cardioprotective effects against ischemic injury via the PKCε/Akt pathway. | Journal of cellular biochemistry | shRNA | TL503002 |
| Gys1 | The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival | The Journal of Cell Biology | shRNA | TF509807 |
| HABP2 | Hyaluronic Acid Binding Protein 2 Is a Novel Regulator of Vascular Integrity | Arterioscler Thromb Vasc Biol, Mar 2010; 30: 483 - 490 | shRNA | TR312532 |
| HAND1 | Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome | PLoS ONE July 2014 | shRNA | TR316857 |
| HAX1 | Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration | Genes Cancer March 2014 | shRNA | TF312515 |
| HCAR2 | Hippuric acid and 3-(3-hydroxyphenyl) propionic acid inhibit murine osteoclastogenesis through RANKL-RANK independent pathway | J. Cell. Physiol. | shRNA | TR511005 |
| HDAC1 | Chronic sun exposure is associated with distinct histone acetylation changes in human skin | Br. J. Dermatol.2017 | shRNA | TR312496 |
| HDAC1 | Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacteylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B Cell Acute Lymphoblastic Leukemia | J. Biol. Chem. | shRNA | TG312496 |
| HDAC1 | Nuclear Localization of the Transcriptional Regulator MIER1a Requires Interaction with HDAC1/2 in Breast Cancer Cells | PLoS ONE Dec 2013. | shRNA | TG312496 |
| HDAC1 | Histone Deacetylase 2 Cell Autonomously Suppresses Excitatory and Enhances Inhibitory Synaptic Function in CA1 Pyramidal Neurons | J. Neurosci., Apr 2013; 33: 5924 - 5929. | shRNA | TG312496 |
| HDAC1 | Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases | Mol. Pharmacol., Jan 2011; 79: 197 - 206 | shRNA | TR312496 |
| HDAC2 | Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas | Clin. Cancer Res. | shRNA | TG312495 |
| HDAC2 | LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1 | J. Cell. Sci. | shRNA | TG312495 |
| HDAC2 | HDAC2-dependent Deacetylation of MORF4L1 Enhances Its Homodimerization | J. Biol. Chem., Jan 2014. | shRNA | TG312495 |
| HDAC2 | Histone Deacetylase 2 (HDAC2) Protein-dependent Deacetylation of Mortality Factor 4-like 1 (MORF4L1) Protein Enhances Its Homodimerization | Journal of Biological Chemistry | shRNA | TG312495 |
| HDAC2 | Nuclear Localization of the Transcriptional Regulator MIER1a Requires Interaction with HDAC1/2 in Breast Cancer Cells | PLoS ONE Dec 2013. | shRNA | TG312495 |
| HDAC2 | Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases | Mol. Pharmacol., Jan 2011; 79: 197 - 206 | shRNA | TR312495 |
| HDAC3 | Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model | Proc. Natl. Acad. Sci. U.S.A. | shRNA | TG500941 |
| HDAC3 | Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases | Mol. Pharmacol., Jan 2011; 79: 197 - 206 | shRNA | TR312494 |
| HDAC4 | Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation | Oncogene (17 January 2011) doi:10.1038/onc.2010.600 Original Article | shRNA | TR312493 |
| HDAC5 | HDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer | Oncotarget | shRNA | TG312492 |
| HDAC6 | HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSa | Mol. Cell | shRNA | TR312491 |
| HDAC6 | Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases | Mol. Pharmacol., Jan 2011; 79: 197 - 206 | shRNA | TR312491 |
| HDAC6 | Histone deacetylase 6 interacts with the microtubule-associated protein tau | Journal of Neurochemistry. 106(5):2119-2130, September 2008 | shRNA | TR312491 |
| HDAC8 | Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases | Mol. Pharmacol., Jan 2011; 79: 197 - 206 | shRNA | TR304143 |
| HECTD1 | HECTD1 regulates the expression of SNAIL: Implications for epithelial‑mesenchymal transition | Int J Oncol | shRNA | TF304134 |
| HES1 | Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells | Blood, Aug 2013; 122: 1162 - 1173. | shRNA | TG312478 |
| HES1 | Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression | Blood, Mar 2011; 117: 2891 - 2900 | shRNA | TR312478 |
| HES5 | Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development | Development. 2013 Dec;140(23):4751-62 | shRNA | TG312477 |
| Hes5 | Histone methyltransferase enhancer of zeste homolog 2 regulates Schwann cell differentiation. | Glia | shRNA | TG711044 |
| HEXIM1 | Identification of HEXIM1 as a Positive Regulator of p53 | J. Biol. Chem., Oct 2012; 287: 36443 - 36454. | shRNA | TG312473 |
| HHEX | A runaway PRH/HHEX-Notch3 positive feedback loop drives cholangiocarcinoma and determines response to CDK4/6 inhibition | Cancer Res. | shRNA | TR312464 |
| HHEX | PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin | Oncogene | shRNA | TG312464 |
| HHEX | DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers | Nucleic Acids Res., Jul 2010; 10.1093/nar/gkq659. | shRNA | TR312464 |
| HHEX | PRH/HHex controls cell survival through coordinate transcriptional regulation of VEGF signalling | Mol. Cell. Biol., May 2010; 30: 2120 - 2134 | shRNA | TR312464 |
| HHIP | Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms | Blood Cancer Journal 2, e87 doi:10.1038/bcj.2012.36 | shRNA | TR304118 |
| HIF1A | Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer | Journal of Experimental & Clinical Cancer Research : CR | shRNA | TL320380 |
| HIF1A | ERK regulates HIF-1α-mediated platinum resistance by directly targeting PHD2 in ovarian cancer | Clin. Cancer Res. | shRNA | TG320380 |
| Hif1a | Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia | Oncogene | shRNA | TR517255 |
| HIF1A | Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease | J. Cell. Mol. Med. | shRNA | TR320380 |
| HIF1A | Hypoxic niche-mediated regeneration of hematopoiesis in the engraftment window is dominantly affected by oxygen tension in the milieu | Stem Cells Dev. | shRNA | TF517255 |
| HIF1A | Hypoxia-Sensitive Epigenetic Regulation of an Antisense-Oriented lncRNA Controls WT1 Expression in Myeloid Leukemia Cells | PLoS ONE | shRNA | TR320380 |
| HIF1A | Regulation of Noxa-mediated apoptosis in Helicobacter pylori-infected gastric epithelial cells | FASEB J. | shRNA | TG320380 |
| HIF1A | A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth Through HIF-1/2a | J. Biol. Chem. | shRNA | TG320380 |
| HIF1A | The dual PI3K/mTOR inhibitor NVP-BEZ235 prevents epithelial-mesenchymal transition induced by hypoxia and TGF-β1 | Eur. J. Pharmacol., Feb 2014. | shRNA | TG320380 |
| HIF1A | Tirapazamine Sensitizes Hepatocellular Carcinoma Cells to Topoisomerase I Inhibitors via Cooperative Modulation of Hypoxia-Inducible Factor-1a | Mol. Cancer Ther. Dec 2013. | shRNA | TG320380 |
| Hif1a | Adenosine A(2)A receptor but not HIF-1 mediates Tyrosine hydroxylase induction in hypoxic PC12 cells. | Journal of neuroscience research | shRNA | TR517255 |
| HIF1A | Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion | British Journal of Cancer (15 December 2009) doi:10.1038/sj.bjc.6605486 Full Paper | shRNA | TR320380 |
| HIF1A | Role of HIF-1 and NF-B Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals | J. Biol. Chem., Jul 2008; 283: 20674 - 20686 | shRNA | TR517255 |
| HIP1 | HIP1 mediates oncogenic transformation and cancer progression through STAT3 signalling | bioRxiv | shRNA | TR312457 |
| HIRA | Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth | Human genetics | shRNA | TF500962 |
| HK2 | Regulation of VDAC trafficking modulates cell death | Cell Death Discov | shRNA | TR312415 |
| HLA-DRA | CIITA enhances HIV-1 attachment to CD4+ T cells leading to enhanced infection and cell depletion. | Journal of immunology (Baltimore, Md. : 1950) | shRNA | TG304088 |
| HLA-DRA | CIITA Enhances HIV-1 Attachment to CD4+ T Cells Leading to Enhanced Infection and Cell Depletion | J. Immunol., Dec 2010; 185: 6480 - 6488 | shRNA | TG304088 |
| HMGA2 | Chaperoning HMGA2 Protein Protects Stalled Replication Forks in Stem and Cancer Cells | Cell Rep, Feb 2014. | shRNA | TR319507 |
| HMGB1 | Intracellular translocation of HMGB1 is important for Zika virus replication in Huh7 cells | Scientific Reports | shRNA | TL316576 |
| HMGB1 | HMGB1 contributes to adriamycin-induced cardiotoxicity via up-regulating autophagy | Toxicol. Lett. | shRNA | TG316576 |
| HMGB1 | Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells | Mol Med Rep | shRNA | TG316576 |
| HMGB1 | HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells | Mol Med Rep | shRNA | TG316576 |
| HMGB1 | Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis | Tumour Biol. | shRNA | TG316576 |
| HMGB1 | Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line: contribution to chronic inflammation in fat tissue | PLoS One. 2013 Sep 20;8(9):e76039 | shRNA | TR316576 |
| HMGCS2 | Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate | J. Lipid Res., Mar 2013; 54: 592 - 601. | shRNA | TR312391 |
| HMGCS2 | Human HMGCS2 Regulates Mitochondrial Fatty Acid Oxidation and FGF21 Expression in HepG2 Cell Line | J. Biol. Chem., Jun 2011; 286: 20423 - 20430 | shRNA | TR312391 |
| HMGN2 | Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells | J. Biol. Chem | shRNA | TF319505 |
| HMOX1 | Hypoxia‐induced oxidative stress promotes therapy resistance via upregulation of heme oxygenase‐1 in multiple myeloma | Cancer Medicine | shRNA | TL312388 |
| HMOX1 | 4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression | Oncotarget | shRNA | TR312388 |
| HMOX1 | The Flavonoid, Eriodictyol, Induces Long-term Protection in ARPE-19 Cells through Its Effects on Nrf2 Activation and Phase 2 Gene Expression | Invest. Ophthalmol. Vis. Sci., May 2009; 50: 2398 - 2406. | shRNA | TR312388 |
| Hmox2 | Heme oxygenase-2 deletion impairs macrophage function: implication in wound healing | FASEB J. | shRNA | TR514171 |
| HNF1B | Inhibition of Cell Death and Induction of G2 Arrest Accumulation in Human Ovarian Clear Cells by HNF-1ß Transcription Factor: Chemosensitivity Is Regulated by Checkpoint Kinase CHK1 | Int. J. Gynecol. Cancer | shRNA | TG308907 |
| HNF4A | Modification in Oxidative Stress, Inflammation, and Lipoprotein Assembly in Response to Hepatocyte Nuclear Factor 4{alpha} Knockdown in Intestinal Epithelial Cells | J. Biol. Chem., Dec 2010; 285: 40448 - 40460 | shRNA | TR320382 |
| HNRNPC | The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene | Mol. Cell. Biol., Nov 2008; 28: 6929 - 6938 | shRNA | TR304074 |
| HNRNPK | Anxiety-associated alternative polyadenylation of the serotonin transporter mRNA confers translational regulation by hnRNPK | PNAS, Jul 2013; 110: 11624 - 11629. | shRNA | TG712371 |
| HNRNPL | HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells | Sci Rep | shRNA | TG312371 |
| HNRNPL | Separate cis-trans Pathways Post-transcriptionally Regulate Murine CD154 (CD40 Ligand) Expression: A NOVEL FUNCTION FOR CA REPEATS IN THE 3'-UNTRANSLATED REGION | J. Biol. Chem., Sep 2008; 283: 25606 - 25616 | shRNA | TR312371 |
| HNRNPM | The Role of the Carcinoembryonic Antigen Receptor in Colorectal Cancer Progression | Journal of Integrative Oncology | shRNA | TR304071 |
| HOXA10 | HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma | Int J Clin Exp Pathol | shRNA | TG316581 |
| Hoxa11 | Knockdown of Hoxa11 in vivo in the uterosacral ligament and uterus of mice results in altered collagen and matrix metalloproteinase activity. | Biology of reproduction | shRNA | TL512291 |
| HOXA11 | Knockdown of Hoxa11 In Vivo in the Uterosacral Ligament and Uterus of Mice Results in Altered Collagen and Matrix Metalloproteinase Activity | Biol Reprod, Jul 2012; 86: 100. | shRNA | TR312366 |
| HOXA11 | HoxA-11 and FOXO1A Cooperate to Regulate Decidual Prolactin Expression: Towards Inferring the Core Transcriptional Regulators of Decidual Genes | PLoS ONE 4(9): e6845. doi:10.1371/journal.pone.0006845 | shRNA | TR312366 |
| HOXA13 | Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells | Stem Cells | shRNA | TR312365 |
| Hoxa9 | TWIST1-WDR5- Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis | Cancer research | shRNA | TL500979 |
| HOXA9 | TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis | Cancer Res. | shRNA | TG307647 |
| HOXA9 | TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis | Cancer Res. | shRNA | TG500979 |
| HOXA9 | Transcriptional profiling of HOXA9-regulated genes in human glioblastoma cell models | Genomics Data | shRNA | TG307647 |
| HOXA9 | Transcriptional profiling of HOXA9-regulated genes in humanglioblastoma cell models | Genomics Data | shRNA | TG307647 |
| HOXA9 | A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide | Oncotarget | shRNA | TG307647 |
| HOXA9 | HOXA9 promotes homotypic and heterotypic cell interactions that facilitate ovarian cancer dissemination via its induction of P-cadherin | Mol. Cancer July 2014 | shRNA | TG307647 |
| HOXB5 | HOXB5 promotes malignant progression in pancreatic cancer via the miR-6732 pathway | Cell Cycle | shRNA | TR312357 |
| HPSE | Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury | FASEB J. | shRNA | TF307138 |
| HPSE | Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) Injury | PLoS ONE | shRNA | TR307138 |
| HPSE | Everolimus-induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase | J Transl Med 292 | shRNA | TR307138 |
| HPSE | Heparanase and Syndecan-1 Interplay Orchestrates Fibroblast Growth Factor-2-induced Epithelial-Mesenchymal Transition in Renal Tubular Cells | J. Biol. Chem., Jan 2012; 287: 1478 - 1488. | shRNA | TR307138 |
| HPSE | Heparanase Alters Arterial Structure, Mechanics, and Repair Following Endovascular Stenting in Mice | Circulation Research:Volume 104(3)13 February 2009pp 380-387 | shRNA | TR307138 |
| HRAS | The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation | Cell Rep | shRNA | TR704050 |
| HS6ST1 | Ovarian Cancer Cell Heparan Sulfate 6-O-Sulfotransferases Regulate an Angiogenic Program Induced by HB-EGF/EGF Receptor Signaling | J. Biol. Chem., Feb 2014. | shRNA | TG312328 |
| HSF1 | Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. | Cellular signalling | shRNA | TR312318 |
| HSP90B1 | Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. | Cellular signalling | shRNA | TR312309 |
| Hspa1a | Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity | Oncogene | shRNA | TF312308 |
| Hspa1b | Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity | Oncogene | shRNA | TF312307 |
| Hspa5 | Knockdown of endoplasmic reticulum chaperone BiP leads to the death of parvocellular AVP/CRH neurons in mice. | Journal of neuroendocrinology | shRNA | TR500881 |
| Hspa5 | Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice | Scientific Reports | shRNA | TR500881 |
| HSPA5 | The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (a-syn) toxicity to rat nigral neurons | Neurobiol. Aging | shRNA | TG312303 |
| HSPA5 | The Loss of Glucose Regulated Protein 78 (GRP78) during Normal Aging or from siRNA Knockdown Augments Human Alpha-Synuclein (a-syn) Toxicity to Rat Nigral Neurons | Neurobiology of Aging | shRNA | TG312303 |
| Hspa8 | The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization | J Biol Chem | shRNA | TR501001 |
| Hspa9 | HSPA9/Mortalin mediates axo-protection and modulates mitochondrial dynamics in neurons | Scientific Reports | shRNA | TL704140 |
| Hspa9 | HSPA9/Mortalin mediates axo-protection and modulates mitochondrial dynamics in neurons | Scientific Reports | shRNA | TR704140 |
| HSPB1 | Heat shock protein 27 inhibits HMGB1 translocation by regulating CBP acetyltransferase activity and ubiquitination | Mol. Immunol. | shRNA | TR320383 |
| Hspb1 | Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation | Mucosal Immunol | shRNA | TG501011 |
| HSPB1 | HSP27 phosphorylation modulates TRAIL-induced activation of Src-Akt/ERK signaling through interaction with Beta-arrestin2 | Cell. Signal. Dec 2013. | shRNA | TR320383 |
| HSPB1 | Regulation of lipopolysaccharide-induced inflammatory response by heat shock protein 27 in THP-1 cells. | Cellular immunology | shRNA | TR320383 |
| HSPB1 | HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination. | Cellular signalling | shRNA | TR320383 |
| ID1 | Avian reovirus σA-modulated suppression of lactate dehydrogenase and upregulation of glutaminolysis and the mTOC1/eIF4E/HIF-1α pathway to enhance glycolysis and the TCA cycle for virus replication. | Cellular microbiology | shRNA | TG303996 |
| ID1 | CCAAT/Enhancer Binding Protein β inhibits myogenic differentiation via ID3 | Sci Rep | shRNA | TR511687 |
| ID3 | CCAAT/Enhancer Binding Protein β inhibits myogenic differentiation via ID3 | Sci Rep | shRNA | TR501033 |
| ID4 | Inhibitor of DNA binding-4 promotes angiogenesis and growth of glioblastoma multiforme by elevating matrix GLA levels | Oncogene (10 May 2010) doi:10.1038/onc.2010.147 Original Article | shRNA | TR319484 |
| IDH2 | Metabolic profiling reveals distinct metabolic alterations in different subtypes of pituitary adenomas and confers therapeutic targets | J Transl Med | shRNA | TF702283 |
| IDH2 | Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells | Int. J. Biochem. Cell Biol. | shRNA | TG312260 |
| IDH3B | Avian reovirus σA-modulated suppression of lactate dehydrogenase and upregulation of glutaminolysis and the mTOC1/eIF4E/HIF-1α pathway to enhance glycolysis and the TCA cycle for virus replication | Cell. Microbiol. | shRNA | TG303995 |
| IDO1 | Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer. | Cancer & metabolism | shRNA | TL312147 |
| IDO1 | INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IS UPREGULATED IN THYROID CARCINOMA AND DRIVES THE DEVELOPMENT OF AN IMMUNOSUPPRESSANT TUMOR MICROENVIRONMENT | J. Clin. Endocrinol. Metab., Feb 2014. | shRNA | TG312147 |
| IDUA | Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores | J. Cell Biol., Jun 2008; 10.1083/jcb.200712028. | shRNA | TR312256 |
| IFI16 | Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells | PLoS Pathog. | shRNA | TR312254 |
| Ifi203 | Silencing of the interferon-inducible gene Ifi204/p204 induces resistance to interferon-γ-mediated cell growth arrest of tumor cells. | Cytokine | shRNA | TL517645 |
| IFITM1 | Respiratory Syncytial Virus Infection is Inhibited by Interferon-Induced Transmembrane Proteins | J. Gen. Virol. | shRNA | TG312242 |
| IFITM2 | Respiratory Syncytial Virus Infection is Inhibited by Interferon-Induced Transmembrane Proteins | J. Gen. Virol. | shRNA | TG312241 |
| IFITM3 | Respiratory Syncytial Virus Infection is Inhibited by Interferon-Induced Transmembrane Proteins | J. Gen. Virol. | shRNA | TG303991 |
| IFNAR1 | Exclusive Temporal Stimulation of IL-10 Expression in LPS-Stimulated Mouse Macrophages by cAMP Inducers and Type I Interferons | Front Immunol | shRNA | TG312233 |
| IFNAR1 | Type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE(2)M17 human neuroblastoma cells | J Neuroinflammation | shRNA | TG312233 |
| IFNAR1 | Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease | Neurobiol. Aging Dec 2013. | shRNA | TR312233 |
| IFNAR1 | Type-1 interferon signalling mediates neuro-inflammatory events in models of Alzheimer's disease | Neurobiology of Aging | shRNA | TG312233 |
| IFNLR1 | IL28RA inhibits human epidermal keratinocyte proliferation by inhibiting cell cycle progression. | Molecular biology reports | shRNA | TR303938 |
| IGF1 | Acute Inflammation Induces Insulin-like Growth Factor-1 to Mediate Bcl-2 and Muc5ac Expression in Airway Epithelial Cells | Am. J. Respir. Cell Mol. Biol., Dec 2012; 47: 784 - 791. | shRNA | TG319480 |
| IGF1 | Intracellular Insulin-like Growth Factor-1 Induces Bcl-2 Expression in Airway Epithelial Cells | J. Immunol., May 2012; 188: 4581 - 4589. | shRNA | TR319480 |
| IGF1R | Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer | Matrix Biology Plus | shRNA | TG320384 |
| IGF1R | Procyanidins from Cinnamomi Cortex promote proteasome-independent degradation of nuclear Nrf2 through phosphorylation of insulin-like growth factor-1 receptor in A549 cells | Arch. Biochem. Biophys. | shRNA | TG320384 |
| IGF1R | TGFß signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells | Mol. Carcinog. | shRNA | TG320384 |
| IGF1R | Regulación de la captación de glucosa en astrocitos por el eje insulina/IGF-I | Thesis | shRNA | TG320384 |
| IGF1R | TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling | Hum. Mol. Genet., Mar 2011; 10.1093/hmg/ddr076 | shRNA | TR320384 |
| IGF2BP3 | IGF2BP3-mediated translation in cell protrusions promotes cell invasiveness and metastasis of pancreatic cancer | Oncotarget | shRNA | TG312221 |
| IGFBP2 | Novel anti IGFBP2 single chain variable fragment inhibits glioma cell migration and invasion. | Journal of neuro-oncology | shRNA | TR316590 |
| IGFBP3 | STAT-1 expression is regulated by IGFBP-3 in malignant glioma cells and is a strong predictor of poor survival in patients with glioblastoma | J. Neurosurg. | shRNA | TF312217 |
| Igfbp4 | IGFBP-4 activates the Wnt/beta-catenin signaling pathway and induces M-CAM expression in human renal cell carcinoma. | International journal of cancer | shRNA | TL510928 |
| IGFBP5 | Genetic Screen Identifies Insulin-like Growth Factor Binding Protein 5 as a Modulator of Tamoxifen Resistance in Breast Cancer | Cancer Res., Apr 2010; 70: 3013 - 3019 | shRNA | TR316591 |
| IGFBP7 | Insulin-like growth factor-binding protein 7 alters the sensitivity to interferon-based anticancer therapy in hepatocellular carcinoma cells | British Journal of Cancer (20 April 2010) doi:10.1038/sj.bjc.6605669 Full Paper | shRNA | TR312216 |
| Igsf11 | Promotion of differentiation in developing mouse cerebellar granule cells by a cell adhesion molecule BT-IgSF. | Neuroscience letters | shRNA | TL506226 |
| IHH | Endogenously-produced Indian Hedgehog Regulates TGFß-driven Chondrogenesis of Human Bone Marrow Stromal/Stem Cells | Stem Cells Dev. | shRNA | TG312208 |
| IKBKB | A constitutively-active IKK-complex at the axon initial segment | Brain Res. | shRNA | TG509787 |
| IKBKE | Glucose Metabolism Reprogrammed by Overexpression of IKKe Promotes Pancreatic Tumor Growth | Cancer Res | shRNA | TG517180 |
| IKZF1 | Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia | Int J Mol Sci | shRNA | TG502473 |
| IKZF1 | RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia | J Cancer | shRNA | TG502473 |
| IKZF1 | Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia | Oncogenesis | shRNA | TG308127 |
| IKZF1 | Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia | Oncotarget | shRNA | TG308127 |
| IKZF1 | Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia | Sci Rep | shRNA | TG308127 |
| IKZF1 | Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacteylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B Cell Acute Lymphoblastic Leukemia | J. Biol. Chem. | shRNA | TG308127 |
| Il10 | The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis. | Journal of immunology (Baltimore, Md. : 1950) | shRNA | TF501065 |
| IL15RA | IL15RA is required for osteoblast function and bone mineralization | Bone | shRNA | TR501072 |
| Il15ra | Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling | Oncotarget | shRNA | TG501072 |
| IL18 | TLR2 controls the development of hepatocellular carcinoma by reducing interleukin-18-mediated immunosuppression | Cancer Res. | shRNA | TG510212 |
| IL1A | Mitogen-Activated Protein Kinase-Dependent Interleukin-1a Intracrine Signaling Is Modulated by YopP during Yersinia enterocolitica Infection | Infect. Immun., Jan 2012; 80: 289 - 297. | shRNA | TR312183 |
| IL1R1 | Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling | Oncotarget | shRNA | TG501076 |
| IL22 | Downregulation of miR‐26 promotes invasion and metastasis via targeting interleukin‐22 in cutaneous T‐cell lymphoma | Cancer Science | shRNA | TL303948 |
| IL33 | Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity | Stem Cell Reports | shRNA | MR203528 |
| IL3RA | Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3 | Leukemia | shRNA | TG516353 |
| IL6 | Autocrine IL-6 mediates pituitary tumor senescence | Oncotarget | shRNA | TG709233 |
| IL6 | Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes | J. Orthop. Res. | shRNA | TG312162 |
| IL6 | Metastatic Cells Can Escape the Proapoptotic Effects of TNF-a through Increased Autocrine IL-6/STAT3 Signaling | Cancer Res., Feb 2012; 72: 865 - 875. | shRNA | TR312162 |
| IL6RA | Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages | Nature Immunology 12, 551-559 (24 April 2011) doi:10.1038/ni.2030 Article | shRNA | TR501088 |
| IL6ST | Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages | Nature Immunology 12, 551-559 (24 April 2011) doi:10.1038/ni.2030 Article | shRNA | TR501089 |
| ILK | CCN1 induces a reversible epithelial–mesenchymal transition in gastric epithelial cells | Laboratory Investigation (10 May 2010) doi:10.1038/labinvest.2010.101 Research Article | shRNA | TR712638 |
| IMMT | Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone | Neurobiol. Dis. | shRNA | TR312153 |
| IMPDH2 | IMPDH2 mediate radioresistance and chemoresistance in osteosarcoma cells | Eur Rev Med Pharmacol Sci | shRNA | TR312150 |
| INAVA | INAVA promotes aggressiveness of papillary thyroid cancer by upregulating MMP9 expression | Cell Biosci | shRNA | TR306059 |
| ING1 | Tumour suppressor ING1b maintains genomic stability upon replication stress | Nucleic Acids Res., Jan 2011; 10.1093/nar/gkq1337 | shRNA | TR312146 |
| Inhba | In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma | Nature Communications | shRNA | TR516955 |
| Inpp5d | IVIG activates FcγRIIB-SHIP1-PIP3 Pathway to stabilize mast cells and suppress inflammation after ICH in mice | Sci Rep | shRNA | TG516227 |
| INPPL1 | The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics | J. Cell Biol., Aug 2010; 10.1083/jcb.201005018 | shRNA | TR312134 |
| INSIG2 | Insulin-induced gene 2 expression correlates with colorectal cancer metastasis and disease outcome | IUBMB Life | shRNA | TG303915 |
| INSR | Regulación de la captación de glucosa en astrocitos por el eje insulina/IGF-I | Thesis | shRNA | TG320387 |
| IPMK | Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death | Sci. Signal., Apr 2013; 6: ra22. | shRNA | TG303904 |
| IPO7 | Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-ras(LA1) Lung Cancer Mice | Anticancer Res. | shRNA | TF312126 |
| IRF6 | TGFß3 Regulates Periderm Removal through ?Np63 in the Developing Palate | J. Cell. Physiol. | shRNA | TR312109 |
| IRF7 | Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro | J Neuroinflammation | shRNA | TR315487 |
| IRF7 | Translational control of the innate immune response through IRF-7 | Nature 452, 323 - 328 (13 Feb 2008) | shRNA | TR315487 |
| Irf8 | DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes including interferon regulatory factor 8 | Kidney international | shRNA | TG701093 |
| IRF8 | Interferon Regulatory Factor 8 Protects Against Cerebral Ischaemic-Reperfusion Injury | J. Neurochem., Feb 2014. | shRNA | TG701093 |
| IRS1 | Expression levels of insulin receptor substrate-1 modulate the osteoblastic differentiation of mesenchymal stem cells and osteosarcoma cells | Growth Factors, Jan 2014. | shRNA | TF516309 |
| ISLR | Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy | Nat Commun | shRNA | TG512833 |
| ITGA2 | CD49b inhibits osteogenic differentiation and plays an important role in osteosarcoma progression | Oncotarget | shRNA | TG312097 |
| ITGB1 | Physical and Functional Interactions between a Glioma Cation Channel and Integrin ß1 Require a-Actinin | Am. J. Physiol., Cell Physiol. | shRNA | TG320392 |
| ITGB1 | Effect of Brain- and Tumor-Derived Connective Tissue Growth Factor on Glioma Invasion | J Natl Cancer Inst, Aug 2011; 103: 1162 - 1178. | shRNA | TR320392 |
| ITGB1 | Extracellular matrix-induced transforming growth factor-beta receptor signaling dynamics. | Oncogene | shRNA | TR320392 |
| ITGB1 | Extracellular matrix-induced transforming growth factor-ß receptor signaling dynamics | Oncogene (25 January 2010) doi:10.1038/onc.2009.514 Original Article | shRNA | TR320392 |
| ITGB3 | Estudio de los mecanismos celulares y moleculares implicados en la adhesión y migración de células de carcinoma pulmonar no microcítico inducidas por TGFß | Thesis | shRNA | TR312082 |
| ITGB3 | Inhibition of tumor-associated avß3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo | Angiogenesis | shRNA | TR312082 |
| ITGB3 | Combined targeting of TGF-beta1 and integrin beta3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer | Mol. Cancer | shRNA | TR312082 |
| ITGB6 | Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury | The Journal of Clinical Investigation | shRNA | TF312078 |
| ITPR1 | IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice | Biochim Biophys Acta Mol Basis Dis | shRNA | TR517036 |
| ITPR1 | Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism | Front Physiol | shRNA | TF517036 |
| JAG1 | Osteosarcoma cell-intrinsic colony stimulating factor-1 receptor functions to promote tumor cell metastasis through JAG1 signaling | American Journal of Cancer Research | shRNA | TG312059 |
| JAG2 | Distinct Biological Roles for the Notch Ligands Jagged-1 and Jagged-2 | J. Biol. Chem., Jun 2009; 284: 17766 - 17774 | shRNA | TR303860 |
| Jak1 | Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia | Nature genetics | shRNA | TG511227 |
| JAK2 | An activity-dependent determinant of synapse elimination in the mammalian brain | Neuron | shRNA | TF320395 |
| JUN | ICBP90 Regulates MIF Expression, Glucocorticoid Sensitivity, and Apoptosis at the , MIF Immune Susceptibility Locus | Arthritis & rheumatology (Hoboken, N.J.) 2021 | shRNA | TG320397 |
| JUN | Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling | Oncotarget | shRNA | TG501139 |
| JUN | MicroRNA 10b promotes abnormal expression of the proto-oncogene c-Jun in metastatic breast cancer cells | Oncotarget | shRNA | TR320397 |
| Jun | Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML | J. Exp. Med. | shRNA | TG501139 |
| JUN | PNAS Plus: Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activation | PNAS, Oct 2012; 109: E2875 - E2884. | shRNA | TG320397 |
| JUNB | Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils | Nat. Immunol. | shRNA | TF516091 |
| JUNB | Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling | Oncotarget | shRNA | TG516091 |
| Jund | Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling | Oncotarget | shRNA | TG501140 |
| JUND | Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Factor Requires Cellular Transcription Factor JunD To Upregulate HTLV-1 Antisense Transcription from the 3' Long Terminal Repeat | J. Virol., Sep 2012; 86: 9070 - 9078. | shRNA | TG312046 |
| JUP | Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3{sigma} | J. Cell Sci., Jul 2013; 126: 3031 - 3042. | shRNA | TG312045 |
| JUP | Molecular characterization of the tumor/metastasis suppressor activity of plakoglobin | Thesis | shRNA | TG312045 |
| KAT2B | PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription | Nucleic Acids Res., Jan 2011; 39: 429 - 439 | shRNA | TR310589 |
| KAT2B | Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation | J. Cell Sci., Nov 2010; 123: 3718 - 3726 | shRNA | TR310589 |
| Kcna1 | Control and Plasticity of the Presynaptic Action Potential Waveform at Small CNS Nerve Terminals | Neuron | shRNA | TR713329 |
| Kcnc1 | Control and Plasticity of the Presynaptic Action Potential Waveform at Small CNS Nerve Terminals | Neuron | shRNA | TR709473 |
| KCNH2 | A microtranslatome coordinately regulates sodium and potassium currents in the human heart | Elife | shRNA | TG320399 |
| KCNH2 | A microtranslatome coordinately regulates sodium and potassium currents in the heart | bioRxiv | shRNA | TG320399 |
| Kcnh6 | From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion. | Cell reports | shRNA | TL512772 |
| KCNK1 | Kir2.1 and K2P1 channels reconstitute two levels of resting membrane potential in cardiomyocytes | J. Physiol. (Lond.) 2017 | shRNA | TF315498 |
| KCNK1 | TWIK-1 Two-Pore Domain Potassium Channels Change Ion Selectivity and Conduct Inward Leak Sodium Currents in Hypokalemia | Sci. Signal., Jun 2011; 4: ra37. | shRNA | TR315498 |
| KCNQ1 | Synergistic Restoring Effects of Isoproterenol and Magnesium on KCNQ1-Inhibited Bradycardia Cell Models Cultured in Microelectrode Array | Cardiology, Feb 2014. | shRNA | TR711664 |
| KCTD5 | KCTD5, a novel TRPM4‐regulatory protein required for cell migration as a new predictor for breast cancer prognosis | FASEB j. | shRNA | TG303786 |
| KCTD5 | KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence | Front Cell Infect Microbiol | shRNA | TG303786 |
| KDM1A | Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan | Nature Communications | shRNA | TL316984 |
| KDM1A | Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription | PLoS Biol. | shRNA | TF316984 |
| KDM3A | The Hypoxia-Inducible Epigenetic Regulators Jmjd1a and G9a Provide a Mechanistic Link between Angiogenesis and Tumor Growth | Mol. Cell. Biol. July 2014 | shRNA | TG303857 |
| KDM4B | MicroRNA-15a Carried by Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibits the Immune Evasion of Colorectal Cancer Cells by Regulating the KDM4B/HOXC4/PD-L1 Axis | Frontiers in Cell and Developmental Biology | shRNA | TR312052 |
| KDM6B | Folic Acid Remodels Chromatin on Hes1 and Neurog2 Promoters during Caudal Neural Tube Development | J. Biol. Chem., Nov 2010; 285: 36922 - 36932 | shRNA | TR320873 |
| KDR | CD133(+) cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma | Sci Rep | shRNA | TR320400 |
| KDR | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development | Cell Res. | shRNA | TG320400 |
| KDR | Autocrine VEGF signaling promotes cell proliferation and modulates the sorafenib treatment efficacy in hepatocellular carcinoma | Hepatology | shRNA | TG320400 |
| KHK | Ketohexokinase-Dependent Metabolism of Fructose Induces Proinflammatory Mediators in Proximal Tubular Cells | . Am. Soc. Nephrol., Mar 2009; 20: 545 - 553. | shRNA | TR311985 |
| KHSRP | KHSRP-bound small nucleolar RNAs associate with promotion of cell invasiveness and metastasis of pancreatic cancer | Oncotarget | shRNA | TR311984 |
| KHSRP | KSRP Modulation of GAP-43 mRNA Stability Restricts Axonal Outgrowth in Embryonic Hippocampal Neurons | PLoS ONE e79255 | shRNA | TG311984 |
| KIF11 | Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms | Sci Rep | shRNA | TG501174 |
| KIF13B | Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms | Sci Rep | shRNA | TG517925 |
| Kif19a | Production of transgenic mice by random recombination of targeted genes in female germline stem cells | J Mol Cell Biol, Dec 2010; 10.1093/jmcb/mjq043 | shRNA | TR517467 |
| KIF20A | Aberrant KIF20A Expression Is Associated with Adverse Clinical Outcome and Promotes Tumor Progression in Prostate Cancer | Dis. Markers | shRNA | TG311916 |
| KIF20A | KIF20A Affects the Prognosis of Bladder Cancer by Promoting the Proliferation and Metastasis of Bladder Cancer Cells | Disease Markers | shRNA | TG311916 |
| KIF20A | KIF20A-Mediated RNA Granule Transport System Promotes the Invasiveness of Pancreatic Cancer Cells | Neoplasia | shRNA | TG311916 |
| KIF21A | Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms | Sci Rep | shRNA | TG501180 |
| KIF21B | Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms | Sci Rep | shRNA | TG501181 |
| KIF23 | Aberrant KIF20A Expression Is Associated with Adverse Clinical Outcome and Promotes Tumor Progression in Prostate Cancer | Disease Markers | shRNA | TG311914 |
| KIF23 | KIF20A-Mediated RNA Granule Transport System Promotes the Invasiveness of Pancreatic Cancer Cells | Neoplasia (New York, N.Y.) | shRNA | TG311914 |
| KIF3A | Live-Cell Imaging Evidence for the Ciliary Transport of Rod Photoreceptor Opsin by Heterotrimeric Kinesin-2 | J. Neurosci., Aug 2012; 32: 10587 - 10593. | shRNA | TR311911 |
| Kif3b | Molecular Motor KIF3B Acts as a Key Regulator of Dendritic Architecture in Cortical Neurons | Frontiers in Cellular Neuroscience | shRNA | TL501182 |
| KISS1R | KISS1R signaling promotes invadopodia formation in human breast cancer cell via ß-arrestin2/ERK | Cell. Signal. | shRNA | TR303680 |
| KISS1R | Regulation of GPR54 Signaling by GRK2 and {beta}-Arrestin | Mol. Endocrinol., Oct 2009; 10.1210/me.2009-0013 | shRNA | TR303680 |
| KL | Klotho upregulation contributes to the neuroprotection of ligustilide against cerebral ischemic injury in mice | Eur. J. Pharmacol. | shRNA | TG303679 |
| KLF4 | Imbalance of a KLF4-miR-7 auto-regulatory feedback loop promotes prostate cancer cell growth by impairing microRNA processing | Am J Cancer Res | shRNA | TG316853 |
| KLF4 | Putative Tumor-Suppressive Function of Krüppel-Like Factor 4 in Primary Lung Carcinoma | Clin. Cancer Res., Sep 2009; 15: 5688 - 5695 | shRNA | TR316853 |
| KLF5 | Prognostic Value and Function of KLF5 in Papillary Thyroid Cancer | Cancers | shRNA | TR311886 |
| Klf5 | Role of miR-145 in cardiac myofibroblast differentiation. | Journal of molecular and cellular cardiology | shRNA | TG509991 |
| KLF6 | Energy Restriction-mimetic Agents Induce Apoptosis in Prostate Cancer Cells in Part through Epigenetic Activation of KLF6 Tumor Suppressor Gene Expression | J. Biol. Chem., Mar 2011; 286: 9968 - 9976 | shRNA | TR311885 |
| KLHDC8B | The Kelch Protein KLHDC8B Guards against Mitotic Errors, Centrosomal Amplification, and Chromosomal Instability | J. Biol. Chem., Nov 2012; 287: 39083 - 39093. | shRNA | TR318087 |
| KLHDC8B | Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells | PNAS, Sep 2009; 106: 14920 - 14925 | shRNA | TR318087 |
| KLHL34 | Epigenetic Regulation of KLHL34 Predictive of Pathologic Response to Preoperative Chemoradiation Therapy in Rectal Cancer Patients | Int. J. Radiat. Oncol. Biol. Phys. | shRNA | TG307679 |
| KLHL40 | Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage | Differentiation Dec 2013. | shRNA | TG303840 |
| KLK5 | Kallikrein-5 Promotes Cleavage of Desmoglein-1 and Loss of Cell-Cell Cohesion in Oral Squamous Cell Carcinoma | J. Biol. Chem., Mar 2011; 286: 9127 - 9135 | shRNA | TR311870 |
| Kmt2a | Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes | Epigenetics Chromatin | shRNA | TR517798 |
| KMT2D | Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan | Nature Communications | shRNA | TL311461 |
| KRT14 | Platelet-rich plasma activates AKT signaling to promote wound healing in a mouse model of radiation-induced skin injury | J Transl Med | shRNA | TR311838 |
| KRT6A | K16 is a further new candidate for homotypic intermediate filament protein interactions. | Experimental dermatology | shRNA | TG311830 |
| KRT80 | SREBP1 drives KRT80-dependent cytoskeletal changes and invasive behavior in endocrine resistant ERα breast cancer | bioRxiv | shRNA | TF307833 |
| LAMA3 | A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration | Developmental cell | shRNA | TL311804 |
| LAMP1 | Large Putative PEST-like Sequence Motif at the Carboxyl Tail of Human Calcium Receptor Directs Lysosomal Degradation and Regulates Cell Surface Receptor Level | J. Biol. Chem., Feb 2012; 287: 4165 - 4176. | shRNA | TR311795 |
| LAMP1 | Visualizing Microtubule-Dependent Vasopressin Type 2 Receptor Trafficking Using a New High-Affinity Fluorescent Vasopressin Ligand | Endocrinology, Oct 2011; 152: 3893 - 3904. | shRNA | TR311795 |
| LAMP2 | Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane | Nat Commun | shRNA | TR311794 |
| LARP1 | The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer | Nucleic Acids Res. | shRNA | TF303581 |
| LARS1 | PGC-1α Regulates Cell Proliferation, Migration, and Invasion by Modulating Leucyl-tRNA Synthetase 1 Expression in Human Colorectal Cancer Cells. | Cancers | shRNA | TG303577 |
| LCE1H | Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren\'s syndrome | Cell Death Dis | shRNA | TG503987 |
| Lcn2 | Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer | Clin. Cancer Res. | shRNA | TR511895 |
| Lcn2 | Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer | Clin. Cancer Res. | shRNA | MR226233 |
| LCN2 | Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells | PLoS ONE | shRNA | TG311777 |
| LCN2 | Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant | Free radical Research | shRNA | TG311777 |
| LDHA | Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s | Cell Rep | shRNA | TG515372 |
| Leap2 | Liver-expressed antimicrobial peptide 2 elevation contributes to age-associated cognitive decline | JCI Insight | shRNA | TR519691 |
| LEF1 | MicroRNAs Regulate Pituitary Development, and MicroRNA 26b Specifically Targets Lymphoid Enhancer Factor 1 (Lef-1), Which Modulates Pituitary Transcription Factor 1 (Pit-1) Expression | J. Biol. Chem., Nov 2010; 285: 34718 - 34728 | shRNA | TR712526 |
| LEO1 | A role for the RNA pol II–associated PAF complex in AID-induced immune diversification | J. Exp. Med., Oct 2012; 209: 2099 - 2111. | shRNA | TG303551 |
| LEO1 | A role for the RNA pol II–associated PAF complex in AID-induced immune diversification | J. Exp. Med., Sep 2012; 10.1084/jem.20112145. | shRNA | TR303551 |
| LETM1 | LETM1-mediated K+ and Na+ homeostasis regulates mitochondrial Ca2+ efflux | Frontiers in Physiology | shRNA | TR311758 |
| LGR5 | FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells | Biochem. Biophys. Res. Commun. | shRNA | TF311747 |
| LIMK1 | Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects | Nature Medicine 18, 1087-1094 doi:10.1038/nm.2834 | shRNA | TR320403 |
| LINC00261 | LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response | Cancer Res. | shRNA | HC137604 |
| LINC00504 | The LINC00504/Mir-4739/KLK4 Axis Facilitates Cell Proliferation and Suppresses Cell Apoptosis Through Triggering The Wnt/Β-Catenin Pathway In Triple-Negative Breast Cancer Cells | Research Square | shRNA | TR318094 |
| LMBRD1 | LMBD1 protein participates in cell mitosis by regulating microtubule assembly | The Biochemical journal | shRNA | TF303512 |
| LMNA | Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells | PLoS ONE | shRNA | TG303510 |
| LMO1 | LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer | Oncotarget | shRNA | TG311708 |
| LNP1 | Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions | J. Biol. Chem. | shRNA | TR320968 |
| LOC298795 | Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation | Oncotarget | shRNA | TL702077 |
| LOXL2 | Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane | Blood, Oct 2011; 118: 3979 - 3989. | shRNA | TR311699 |
| LPAR1 | High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells | Cell. Physiol. Biochem. | shRNA | TR313300 |
| LPAR1 | Lysophosphatidic acid signaling via LPA1 and LPA3 regulates cellular functions during tumor progression in pancreatic cancer cells | Experimental Cell Research | shRNA | TR313300 |
| LPAR1 | Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells | Mol. Carcinog. | shRNA | TF712271 |
| Lpar1 | LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs | Mol. Cell. Biochem. | shRNA | TG509224 |
| LPAR2 | Roles of endothelial cells in the regulation of cell motility via lysophosphatidic acid receptor-2 (LPA2) and LPA3 in osteosarcoma cells | Experimental and molecular pathology | shRNA | TG313298 |
| LPAR2 | Different effects of lysophosphatidic acid receptor-2 (LPA2) and LPA5 on the regulation of chemoresistance in colon cancer cells | J. Recept. Signal Transduct. Res. | shRNA | TG313298 |
| LPAR2 | Lysophosphatidic acid receptor-2 (LPA2)-mediated signaling enhances chemoresistance in melanoma cells treated with anticancer drugs | Mol. Cell. Biochem. | shRNA | TG313298 |
| LPAR2 | Involvement of LPA signaling via LPA receptor-2 in the promotion of malignant properties in osteosarcoma cells | Exp. Cell Res. | shRNA | TR313298 |
| LPAR2 | Enhanced cellular functions through induction of LPA2 by cisplatin in fibrosarcoma HT1080 cells | Mol. Cell. Biochem | shRNA | TR313298 |
| Lpar2 | LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs | Mol. Cell. Biochem. | shRNA | TG502984 |
| Lpar3 | Effects of lysophosphatidic acid (LPA) receptor-2 (LPA2) and LPA3 on the regulation of chemoresistance to anticancer drug in lung cancer cells | Cell. Signal. | shRNA | TG517410 |
| LPAR3 | High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells | Cell. Physiol. Biochem. | shRNA | TR313295 |
| LPAR3 | Lysophosphatidic acid signaling via LPA1 and LPA3 regulates cellular functions during tumor progression in pancreatic cancer cells | Experimental Cell Research | shRNA | TR313295 |
| LPAR3 | Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells | Mol. Carcinog. | shRNA | TG710942 |
| Lpar3 | LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs | Mol. Cell. Biochem. | shRNA | TG517410 |
| LPAR4 | Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells | Biochem. Biophys. Res. Commun | shRNA | TR312652 |
| LPAR4 | Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells | Biochem. Biophys. Res. Commun. | shRNA | TF312652 |
| LPAR5 | Different effects of lysophosphatidic acid receptor-2 (LPA2) and LPA5 on the regulation of chemoresistance in colon cancer cells | J. Recept. Signal Transduct. Res. | shRNA | TG304222 |
| LPAR5 | LPA5-mediated signaling induced by endothelial cells and anticancer drug regulates cellular functions of osteosarcoma cells | Experimental Cell Research | shRNA | TG304222 |
| LPAR5 | Modulation of chemoresistance by lysophosphatidic acid (LPA) signaling through LPA5 in melanoma cells treated with anticancer drugs | Biochem. Biophys. Res. Commun. | shRNA | TG304222 |
| LPAR5 | Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells | Biochem. Biophys. Res. Commun. | shRNA | TG304222 |
| LPAR5 | Inhibitory effects of lysophosphatidic acid receptor-5 on cellular functions of sarcoma cells | Growth Factors | shRNA | TG304222 |
| LPAR5 | Lysophosphatidic acid receptor-5 negatively regulates cell motile and invasive activities of human sarcoma cell lines | Mol. Cell. Biochem. March 2014 | shRNA | TG304222 |
| Lpar5 | Lysophosphatidic acid receptor-5 negatively regulates cellular responses in mouse fibroblast 3T3 cells | Biochem. Biophys. Res. Commun. | shRNA | TG304222 |
| LPAR6 | Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells | Biochem. Biophys. Res. Commun | shRNA | TR310642 |
| LPAR6 | Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells | Biochem. Biophys. Res. Commun. | shRNA | TF310642 |
| Lpcat1 | Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (Lpcat1) Catalyzes Histone Protein O -Palmitoylation to Regulate mRNA Synthesis | The Journal of Biological Chemistry | shRNA | TL704171 |
| LRP10 | Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes | RNA | shRNA | TL311681 |
| LRP6 | Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis | Research Square | shRNA | TG509944 |
| LRP6 | RASSF10 suppresses lung cancer proliferation and invasion by decreasing the level of phosphorylated LRP6 | Mol. Carcinog. | shRNA | TG311676 |
| Lrrfip1 | The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. | Nature immunology | shRNA | TL514790 |
| LRRFIP1 | The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a ß-catenin-dependent pathway | Nature Immunology 11, 487-494 (9 May 2010) doi:10.1038/ni.1876 Article | shRNA | TR311663 |
| LRRK1 | Immunosuppressive Cyclosporin A Activates AKT in Keratinocytes through PTEN Suppression | The Journal of Biological Chemistry | shRNA | TR200242 |
| LSP1 | Lymphocyte-Specific Protein-1 Controls Sorafenib Sensitivity and Hepatocellular Proliferation through Extracellular Signal-Regulated Kinase 1/2 Activation | The American Journal of Pathology | shRNA | TG702934 |
| LSP1 | Leukocyte specific protein-1: A novel regulator of hepatocellular proliferation and migration deleted in human HCC | Hepatology | shRNA | TG702934 |
| LSR | LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway | Biochemical and Biophysical Research Communications | shRNA | TG303412 |
| LTA | Overexpression of CCN1 in Het1A cells attenuates bile-induced esophageal metaplasia through suppressing non-canonical NFκB activation | Cytokine | shRNA | TR316607 |
| LTA4H | Resveratrol, a Red Wine Polyphenol, Suppresses Pancreatic Cancer by Inhibiting Leukotriene A4 Hydrolase | Cancer Res., Dec 2010; 70: 9755 - 9764 | shRNA | TR311651 |
| LTA4H | [6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A4 Hydrolase | Cancer Res., Jul 2009; 69: 5584 - 5591 | shRNA | TR311651 |
| LTC4S | Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages | Proc. Natl. Acad. Sci. U.S.A. | shRNA | TR319192 |
| LY6E | LY6E Restricts the Entry of Human Coronaviruses, including the currently pandemic SARS-CoV-2 | bioRxiv | shRNA | TR311641 |
| Lypla1 | Palmitoylation couples insulin hypersecretion with β cell failure in diabetes. | Cell metabolism | shRNA | TL709612 |
| MAD2L1 | Phosphoinositide 3-kinase ß regulates chromosome segregation in mitosis | Mol. Biol. Cell, Dec 2012; 23: 4526 - 4542. | shRNA | TG311623 |
| MAFA | Calcineurin/Nuclear Factor of Activated T Cells and MAPK Signaling Induce TNF-{alpha} Gene Expression in Pancreatic Islet Endocrine Cells | J. Biol. Chem., Jan 2011; 286: 1025 - 1036 | shRNA | TR303385 |
| Mafa | Calcineurin/Nuclear Factor of Activated T Cells and MAPK Signaling Induce TNF-? Gene Expression in Pancreatic Islet Endocrine Cells | The Journal of Biological Chemistry | shRNA | TG508549 |
| MAFF | Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths | Cell Rep | shRNA | TF501290 |
| Mageb16 | Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives | Sci Rep | shRNA | TG321071 |
| MAP1LC3B | Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways | PLoS ONE | shRNA | TG503902 |
| MAP2K1 | Cyclin-dependent kinase 5 contributes to endoplasmic reticulum stress induced podocyte apoptosis via promoting MEKK1 phosphorylation at Ser280 in diabetic nephropathy | Cell. Signal | shRNA | TR502589 |
| MAP2K3 | The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling | J Biol Chem. 2005 Dec 23;280(51):42097-105. | shRNA | TR320491 |
| MAP3K8 | Tpl2 Is a Key Mediator of Arsenite-Induced Signal Transduction | Cancer Res., Oct 2009; 69: 8043 - 8049 | shRNA | TR512220 |
| MAP4K4 | HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells | Cell Death Dis | shRNA | TG320615 |
| MAPK1 | p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis | Aging (Albany NY) 2019 | shRNA | TG502598 |
| Mapk10 | Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK | J. Neurosci. | shRNA | TR502599 |
| MAPK14 | p38 MAPK mediates epithelial-mesenchymal transition by regulating p38IP and Snail in head and neck squamous cell carcinoma | Oral Oncology | shRNA | TG320309 |
| Mapk8 | Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK | J. Neurosci. | shRNA | TR511480 |
| Mapk8 | Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2) | Cancer Lett. | shRNA | TR511480 |
| Mapk9 | Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK | J. Neurosci. | shRNA | TR502601 |
| MAPKAPK2 | MAPKAP kinase 2-mediated phosphorylation of HspA1L protects male germ cells from heat stress-induced apoptosis | Cell Stress Chaperones | shRNA | TF512620 |
| MAPKAPK2 | Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis | Mol. Biol. Cell | shRNA | TR320609 |
| MAPKAPK5 | The TLK1–MK5 Axis Regulates Motility, Invasion, and Metastasis of Prostate Cancer Cells | Cancers | shRNA | TL320583 |
| MAPRE2 | EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion | FASEB J. | shRNA | TF311571 |
| MAPRE3 | EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion | FASEB J. | shRNA | TF311570 |
| MAPT | Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus | Pharmacol. Res. | shRNA | TG710015 |
| MAPT | Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD | J. Neurosci. | shRNA | TG710015 |
| Marcks | Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo. | Cancer letters | shRNA | TR512267 |
| MBD4 | Epigenetic silencing of RNF144A expression in breast cancer cells through promoter hypermethylation and MBD4 | Cancer Med | shRNA | TG311558 |
| MBD4 | CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor | Oncogene | shRNA | TG311558 |
| MBD4 | Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. | International journal of oncology | shRNA | TG311558 |
| Mbtps2 | MBTPS2 exacerbates albuminuria in streptozotocin-induced type I diabetic nephropathy by promoting endoplasmic reticulum stress-mediated renal damage. | Archives of physiology and biochemistry | shRNA | TL508125 |
| MCAM | CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor | Oncogene | shRNA | TG311550 |
| MCL1 | ER Stress-Mediated Upregulation of miR-29a Enhances Sensitivity to Neuronal Apoptosis | Eur. J. Neurosci. | shRNA | TG303313 |
| MCL1 | Dinaciclib, a CDK inhibitor promotes proteasomal degradation of Mcl-1 and enhances ABT-737 mediated cell death in malignant human glioma cell lines | J. Pharmacol. Exp. Ther. | shRNA | TR303313 |
| MCL1 | Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis | Apoptosis | shRNA | TG303313 |
| MCL1 | Survivin Inhibitor YM-155 Sensitizes Tumor Necrosis Factor– Related Apoptosis-Inducing Ligand-Resistant Glioma Cells to Apoptosis through Mcl-1 Downregulation and by Engaging the Mitochondrial Death Pathway | J. Pharmacol. Exp. Ther., Aug 2013; 346: 201 - 210. | shRNA | TG303313 |
| MCL1 | YM-155 Potentiates the Effect of ABT-737 in Malignant Human Glioma Cells via Survivin and Mcl-1 Downregulation in an EGFR-Dependent Context | Mol. Cancer Ther., Mar 2013; 12: 326 - 338. | shRNA | TG303313 |
| MCL1 | Inhibition of NF-{kappa}B Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin | J. Biol. Chem., Jun 2010; 285: 19162 - 19172 | shRNA | TR303313 |
| MCOLN1 | Defective Autophagosome Trafficking Contributes to Impaired Autophagic Flux in Coronary Arterial Myocytes Lacking CD38 Gene | Cardiovasc. Res., Jan 2014. | shRNA | TR303307 |
| MCOLN2 | Zinc Dyshomeostasis Is Linked with the Loss of Mucolipidosis IV-associated TRPML1 Ion Channel | J. Biol. Chem., Nov 2010; 285: 34304 - 34308 | shRNA | TR303306 |
| MCU | Molecular tuning of the axonal mitochondrial Ca2+ uniporter ensures metabolic flexibility of neurotransmission | bioRxiv | shRNA | TR704979 |
| MDK | Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling | Stem Cell Reports | shRNA | TG319183 |
| MDM2 | Corosolic acid inhibits cancer progress through inactivating YAP in hepatocellular carcinoma | Oncol. Res. | shRNA | TG311529 |
| MDM2 | Exonuclease-1 interacts with the transcriptional co-repressor KAP1 | Matters | shRNA | TR311529 |
| MDM2 | FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage | Oncogene | shRNA | TG311529 |
| MDM2 | EMILIN1–a4/a9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation | J. Cell Biol., Oct 2011; 195: 131 - 145. | shRNA | TR311529 |
| MECOM | Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition | Oncogene | shRNA | TG313148 |
| MECOM | Identifying a Potential Molecular Therapeutic Target for MLL-AF9 Leukemia | Thesis | shRNA | TG313148 |
| MEF2C | Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths | Cell Rep | shRNA | TF511428 |
| Meg3 | Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity | Elife | shRNA | TG501330 |
| MEG3 | Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway | Am J Transl Res | shRNA | TG320132 |
| MEN1 | miR-29b Modulates Intestinal Epithelium Homeostasis by Repressing Menin Translation | Biochem. J. | shRNA | TG501333 |
| MEOX1 | Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling | Int. J. Cardiol.2017 | shRNA | TG311507 |
| MET | FOXO1 Suppression is a Determinant of Acquired Lapatinib-Resistance in HER2-Positive Gastric Cancer Cells Through MET Upregulation | Cancer Res Treat | shRNA | TG320418 |
| MET | Induction of tumor initiation is dependent on CD44s in c-Met(+) hepatocellular carcinoma | BMC Cancer | shRNA | TG320418 |
| MET | Induction of tumor initiation is dependent on CD44s in c-Met+ hepatocellular carcinoma | BMC Cancer | shRNA | TG320418 |
| Metrnl | Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy. | Journal of advanced research | shRNA | TL702232 |
| MFGE8 | Endometrial MFG-E8 regulates TGF-ß induced EMT promoting trophoblast invasion and implantation | Reproduction | shRNA | TR311492 |
| Mfn2 | Mitofusin 2 Integrates Mitochondrial Network Remodelling, Mitophagy and Renewal of Respiratory Chain Proteins in Neurons after Oxygen and Glucose Deprivation. | Molecular neurobiology | shRNA | TL712567 |
| MGMT | O(6)-Methylguanine-DNA Methyltransferase Is a Novel Negative Effector of Invasion in Glioblastoma Multiforme | Mol. Cancer Ther., Nov 2012; 11: 2440 - 2450. | shRNA | TG316615 |
| MGP | Inhibitor of DNA binding-4 promotes angiogenesis and growth of glioblastoma multiforme by elevating matrix GLA levels | Oncogene (10 May 2010) doi:10.1038/onc.2010.147 Original Article | shRNA | TR311480 |
| Mical1 | Podocyte Shape Regulation by Semaphorin 3A and MICAL-1 | Methods in molecular biology (Clifton, N.J.) | shRNA | TG506165 |
| MICAL1 | Podocyte Shape Regulation by Semaphorin 3A and MICAL-1 | Methods Mol. Biol. | shRNA | TF506165 |
| Micu2 | Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake. | Biochimica et biophysica acta | shRNA | TL712808 |
| MIF | UHRF1 regulates the transcriptional repressor HBP1 through MIF in T acute lymphoblastic leukemia | Oncology reports | shRNA | TR319111 |
| MIF | Macrophage Migration Inhibitory Factor Regulates Akt Signaling in Hypoxic Culture to Modulate Senescence of Human Mesenchymal Stem Cells | Stem Cells Dev. | shRNA | TR319111 |
| MITF | Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia | J. Clin. Invest. | shRNA | TG514672 |
| MKRN2 | Ubiquitous Expression of MAKORIN-2 in Normal and Malignant Hematopoietic Cells and Its Growth Promoting Activity | PLoS ONE | shRNA | TG311466 |
| MLLT11 | Involvement of AF1q/MLLT11 in the progression of ovarian cancer | Oncotarget | shRNA | TF319110 |
| MMP1 | Matrix Metalloproteinase-1 (MMP1) Upregulation through Promoter Hypomethylation Enhances Tamoxifen Resistance in Breast Cancer | Cancers | shRNA | TL311450 |
| MMP1 | Activation of EGFR/p38/HIF-1a is pivotal for angiogenesis and tumorigenesis of malignantly transformed cells induced by hexavalent chromium | J. Biol. Chem. | shRNA | TG311450 |
| MMP13 | Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13 | Tumour Biol. | shRNA | TG311446 |
| Mmp14 | MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo. | Cancer letters | shRNA | TF510301 |
| MMP9 | MMP-9 Reinforces Radiation-Induced Delayed Invasion and Metastasis of Surviving Neuroblastoma Cells Through Second-Signaling Positive Feedback With NFkB Via Both ERK and IKK Activation | Research Square | shRNA | TF311436 |
| MMS19 | IOP1 Protein Is an External Component of the Human Cytosolic Iron-Sulfur Cluster Assembly (CIA) Machinery and Functions in the MMS19 Protein-dependent CIA Pathway | J. Biol. Chem., Jun 2013; 288: 16680 - 16689. | shRNA | TG303224 |
| MORC2 | MORC2 regulates DNA damage response through a PARP1-dependent pathway | Nucleic Acids Research | shRNA | TG311427 |
| MPG | Germ-line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6 ethenoadenine induced mutations | J. Biol. Chem. | shRNA | TR311419 |
| MSH2 | Der Einfluss des Mismatch Reparaturfaktors hMSH2 auf distinkte Reparaturwege der DNA Doppelstrangbruch Reparatur | thesis | shRNA | TR311383 |
| MSH3 | Der Einfluss des Mismatch Reparaturfaktors hMSH2 auf distinkte Reparaturwege der DNA Doppelstrangbruch Reparatur | thesis | shRNA | TR311382 |
| MSH6 | Der Einfluss des Mismatch Reparaturfaktors hMSH2 auf distinkte Reparaturwege der DNA Doppelstrangbruch Reparatur | thesis | shRNA | TR311380 |
| MSI1 | Upregulation of musashi1 increases malignancy of hepatocellular carcinoma via the Wnt/β-catenin signaling pathway and predicts a poor prognosis | BMC Gastroenterol | shRNA | TG311379 |
| MSI1 | The RNA-binding protein Musashi 1 stabilizes the onco tachykinin 1 mRNA in breast cancer cells to promote cell growth | FASEB J. | shRNA | TF311379 |
| MSI2 | Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling | J. Biol. Chem. | shRNA | TF303128 |
| MSLN | Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation | Carcinogenesis, Jul 2011; 32: 1013 - 1024. | shRNA | TR311377 |
| msr1 | Expression of scavenger receptor-AI promotes alternative activation of murine macrophages to limit hepatic inflammation and fibrosis | Hepatology | shRNA | TR515183 |
| MSRA | Methionine sulfoxide reductase A down-regulation in human breast cancer cells results in a more aggressive phenotype | PNAS, Oct 2010; 107: 18628 - 18633 | shRNA | TR316620 |
| MST1 | MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells | Int J Mol Sci | shRNA | TF514455 |
| Mstn | Myostatin induces DNA damage in skeletal muscle of streptozotocin-induced type 1 diabetic mice | J. Biol. Chem., Jan 2014. | shRNA | TG512805 |
| MT2A | Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development | Clin. Cancer Res., Jun 2010; 16: 3193 - 3204 | shRNA | TR319082 |
| MTA1 | Mechanism of TRIM25 mediated ubiquitination of metastasis associated protein (MTA) 1 in normal liver cells | Exp. Cell Res. | shRNA | TR311372 |
| mTOR | Inactivation of the mTORC1-Eukaryotic Translation Initiation Factor 4E Pathway Alters Stress Granule Formation | Mol. Cell. Biol., Jun 2013; 33: 2285 - 2301. | shRNA | TG320364 |
| MUC1 | An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1 | British Journal of Cancer | shRNA | TL316625 |
| MUC1 | MUC1 protein induces urokinase-type plasminogen activator (uPA) by forming a complex with NF-?B p65 transcription factor and binding to the uPA promoter, leading to enhanced invasiveness of cancer cells | J. Biol. Chem. | shRNA | TG316625 |
| MUS81 | Phosphorylation By CK2 Regulates MUS81/EME1 In Mitosis And After Replication Stress | bioRxiv | shRNA | TR303095 |
| MYB | MYB is a novel regulator of pancreatic tumour growth and metastasis | Br. J. Cancer | shRNA | TG311329 |
| MYB | Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53 | Mol. Cell. Biol., Aug 2010; 30: 3981 - 3993 | shRNA | TR311329 |
| MYC | The Genetic Basis of Transcriptional and Spatial Heterogeneity of Squamous Features in Pancreatic Ductal Adenocarcinoma | bioRxiv | shRNA | TF311323 |
| MYC | c-Myc Dependent Cell Competition in Human Cancer Cells | J. Cell. Biochem | shRNA | TF311323 |
| Myc | GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism | J. Immunol. | shRNA | TR509322 |
| MYC | Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas | Blood, Jan 2010; 115: 570 - 580 | shRNA | TR311323 |
| MYC | Regulation of reactive oxygen species homeostasis by peroxiredoxins and c-Myc | J. Biol. Chem., Dec 2008; 10.1074/jbc.M807564200. | shRNA | TR311323 |
| Myct1 | Regulation of Reactive Oxygen Species Homeostasis by Peroxiredoxins and c-Myc | J. Biol. Chem., Mar 2009; 284: 6520 - 6529. | shRNA | TR513832 |
| MYD88 | Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis | MBio | shRNA | TG311320 |
| MYD88 | Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88 | Proc. Natl. Acad. Sci. U.S.A. | shRNA | TG311320 |
| MYH9 | Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation | bioRxiv | shRNA | TF311309 |
| MYH9 | Proteomics Analysis of the Non-Muscle Myosin Heavy Chain IIa-Enriched Actin-Myosin Complex Reveals Multiple Functions within the Podocyte | PLoS ONE | shRNA | TF311309 |
| MYO5A | Myosin Va is Required for the Transport of Fragile X Mental Retardation Protein (FMRP) Granules | shRNA | TR311295 | |
| MYO5A | Myosin Va Is Required for P Body but Not Stress Granule Formation | J. Biol. Chem., Apr 2011; 286: 11519 - 11528 | shRNA | TR311295 |
| MYOD1 | Repression of ESR1 transcription by MYOD potentiates letrozole-resistance in ERα-positive breast cancer cells | Biochem. Biophys. Res. Commun. | shRNA | TR311289 |
| MYOF | Myoferlin-Mediated Lysosomal Exocytosis Regulates Cytotoxicity by Phagocytes | J. Immunol. | shRNA | TR518387 |
| Myt1 | Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming | Stem Cell Reports | shRNA | TG501427 |
| MZF1 | Phosphorylation-dependent stabilization of MZF1 upregulates N-cadherin expression during protein kinase CK2-mediated epithelial-mesenchymal transition | Oncogenesis | shRNA | TG303059 |
| MZF1 | Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of the CCN2/CTGF and CCN3/NOV Genes in the Hematopoietic Compartment | J. Cell. Physiol. | shRNA | TG303059 |
| MZF1 | The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol | Biochem. Biophys. Res. Commun. July 2014 | shRNA | TR303059 |
| NACC1 | NAC-1, a potential stem cell pluripotency factor, contributes to paclitaxel resistance in ovarian cancer through inactivating Gadd45 pathway | Oncogene 28, 1941-1948 (23 March 2009) | shRNA | TR306354 |
| NANOG | The allosteric glycogen synthase kinase-3 inhibitor NP12 limits myocardial remodeling and promotes angiogenesis in an acute myocardial infarction model | J. Biol. Chem. | shRNA | TF303039 |
| NANOG | CD133(+) cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma | Sci Rep | shRNA | TR303039 |
| NANOG | Overexpression of NANOG in Gestational Trophoblastic Diseases: Effect on Apoptosis, Cell Invasion, and Clinical Outcome | Am. J. Pathol., Oct 2008; 173: 1165 - 1172 | shRNA | TR303039 |
| NAT10 | MORC2 regulates DNA damage response through a PARP1-dependent pathway | Nucleic Acids Research | shRNA | TG303028 |
| NBPF1 | NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest | BMC Cancer | shRNA | TR307077 |
| NBPF14 | NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest | BMC Cancer | shRNA | TR303019 |
| NBPF9 | NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest | BMC Cancer | shRNA | TR311258 |
| NBR1 | The p38-activated ER stress-ATF6α axis mediates cellular senescence | FASEB J. | shRNA | TG311256 |
| NCF1 | Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis. | Free radical biology & medicine | shRNA | TR311251 |
| NCF2 | Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis. | Free radical biology & medicine | shRNA | TR311250 |
| NCKAP1 | PTEN dephosphorylates Abi1 to promote epithelial morphogenesis | J. Cell Biol. | shRNA | TF510899 |
| NCOA1 | MicroRNA-223-3p inhibits human bladder cancer cell migration and invasion | Tumour Biol | shRNA | TG320589 |
| NCOA2 | Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection | PLoS Pathog | shRNA | TR311243 |
| NCOA3 | Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection | PLoS Pathog | shRNA | TR320577 |
| NDRG3 | Lactate Promotes Synthetic Phenotype in Vascular Smooth Muscle Cells | Circ. Res. | shRNA | TG303004 |
| NDRG4 | NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients | NPJ Breast Cancer | shRNA | TG303003 |
| NdufA10 | Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency | J. Cell Biol | shRNA | TR311229 |
| NDUFA13 | Repression of GRIM19 expression potentiates cisplatin chemoresistance in advanced bladder cancer cells via disrupting ubiquitination-mediated Bcl-xL degradation | Cancer Chemother. Pharmacol. | shRNA | TR503841 |
| Nedd4l | Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia | Nat. Genet. | shRNA | TG505433 |
| Negative Control | Serum-borne lipids amplify TLR-activated inflammatory responses | J. Leukoc. Biol. | shRNA | TR30013 |
| Negative Control | A β-arrestin-2-dependent mechanism of GPR52 signalling in frontal cortical neurons | ACS Chem Neurosci | shRNA | TR30013 |
| Negative Control | Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling | Biochim Biophys Acta Mol Cell Biol Lipids | shRNA | TR30021 |
| Negative Control | ETS1 Suppresses Tumorigenesis of Human Breast Cancer via Trans-Activation of Canonical Tumor Suppressor Genes | Front Oncol | shRNA | TR30021 |
| Negative Control | Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema | Cell | shRNA | TR30021 |
| negative Control | Mechanism of miR-222 and miR-126 regulation and its role in asbestos-induced malignancy | Int. J. Biochem. Cell Biol. | shRNA | TR30012 |
| Negative Control | Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling | Cell Rep | shRNA | TR30021 |
| negative Control | Acid/bile exposure triggers TRAIL-mediated apoptosis in esophageal cancer cells by suppressing the decoy receptors and c-FLIPR | The International Journal of Biochemistry & Cell Biology | shRNA | TR30012 |
| Negative Control | Hippocampal GABA-inhibitory circuitry regulates despair-like behavior in mice | bioRxiv | shRNA | TR30013 |
| Negative Control | Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior | Cell Rep | shRNA | TR30021 |
| Negative Control | Acute knockdown of Depdc5 leads to synaptic defects in mTOR-related epileptogenesis | Neurobiol. Dis. | shRNA | TR30021 |
| Negative Control | The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I | Cancers (Basel) 2020 | shRNA | TR30021 |
| Negative Control | Interference with SMO increases chemotherapy drug sensitivity of A2780/DDP cells by inhibiting the Hh/Gli signaling pathway | J. Cell. Biochem. | shRNA | TR30021 |
| Negative Control | Bone morphogenetic protein 4 reduces global H3K4me3 to inhibit proliferation and promote differentiation of human neural stem cells | bioRxiv | shRNA | TR30013 |
| Negative Control | TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance | Cell Rep | shRNA | TR30015 |
| Negative Control | Long Noncoding RNA (lncRNA) Maternally Expressed Gene 3 (MEG3) Participates in Chronic Obstructive Pulmonary Disease through Regulating Human Pulmonary Microvascular Endothelial Cell Apoptosis | Med Sci Monit | shRNA | TR30021 |
| Negative Control | miR-181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart | J Am Heart Assoc | shRNA | TR30021 |
| Negative Control | The future of plant biotechnology in a globalized and environmentally endangered world | Genet. Mol. Biol. | shRNA | TR30021 |
| Negative Control | Mechanism associated with aberrant lncRNA MEG3 expression in gestational diabetes mellitus | Exp Ther Med | shRNA | TR30021 |
| Negative Control | RNAi-mediated knockdown of VDR surprisingly suppresses cell growth in Jurkat T and U87-MG cells | Heliyon | shRNA | TR30013 |
| Negative Control | Nitrate uptake and metabolism in human skeletal muscle cell cultures | Nitric Oxide | shRNA | TR30021 |
| Negative Control | Bovine ephemeral fever virus triggers autophagy enhancing virus replication via upregulation of the Src/JNK/AP1 and PI3K/Akt/NF-κB pathways and suppression of the PI3K/Akt/mTOR pathway | Vet. Res. | shRNA | TR30013 |
| Negative Control | Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis | Veterinary Microbiology | shRNA | TR30013 |
| Negative Control | EK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury | Front Mol Neurosci | shRNA | TR30021 |
| Negative Control | Prolactin promotes fibrosis and pancreatic cancer progression | Cancer Res. | shRNA | TR30021 |
| Negative Control | Early growth response 1 regulates hematopoietic support and proliferation in human primary bone marrow stromal cells | Haematologica | shRNA | TR30021 |
| Negative Control | BCDIN3D regulates tRNAHis 3' fragment processing | PLoS Genet. | shRNA | TR30012 |
| Negative Control | HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding | Molecular Cell | shRNA | TR30021 |
| Negative Control | Rudhira/BCAS3 couples microtubules and intermediate filaments to promote cell migration for angiogenic remodeling | Mol. Biol. Cell | shRNA | TR30015 |
| Negative Control | SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor Dasatinib | Cancers (Basel) 2019 | shRNA | TR30012 |
| Negative Control | SORLA regulates endosomal trafficking and oncogenic fitness of HER2 | Nat Commun | shRNA | TR30021 |
| Negative Control | c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer | Mol Oncol | shRNA | TR30012 |
| Negative Control | Antagonistic interactions between osterix and pyrophosphate during cementum formation | Bone | shRNA | TR30013 |
| Negative Control | Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ | Sci Rep | shRNA | TR30021 |
| Negative Control | miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma | Nat Metab | shRNA | TR30021 |
| Negative Control | Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation | Mol. Cell. Biol. | shRNA | TR30015 |
| Negative Control | p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance | Sci Rep | shRNA | TR30003 |
| Negative Control | Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2 | Kidney International | shRNA | TR30021 |
| Negative Control | Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program | Nucleic Acids Res. | shRNA | TR30021 |
| Negative Control | A critical role for the nuclear protein Akirin2 in the formation of mammalian muscle in vivo | Genesis | shRNA | TR30015 |
| Negative Control | The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons | Neurosci. Lett. | shRNA | TR30015 |
| Negative Control | The Genetic Basis of Transcriptional and Spatial Heterogeneity of Squamous Features in Pancreatic Ductal Adenocarcinoma | bioRxiv | shRNA | TR30015 |
| Negative Control | Knockdown of Orphan Transporter SLC22A18 Impairs Lipid Metabolism and Increases Invasiveness of HepG2 Cells | Pharm. Res. | shRNA | TR30012 |
| Negative Control | TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment | Cell Stem Cell | shRNA | TR30021 |
| Negative Control | DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways | Int. J. Oncol. | shRNA | TR30021 |
| Negative Control | Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms | Sci Rep | shRNA | TR30013 |
| Negative Control | Loss of programmed cell death 10 activates tumor cells and leads to temozolomide-resistance in glioblastoma | J. Neurooncol. | shRNA | TR30021 |
| Negative Control | Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1 | PLoS Pathog. | shRNA | TR30021 |
| Negative Control | Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann-Pick C1 mutant cell via lysosome-associated membrane protein 1 | Cell Death Dis | shRNA | TR30021 |
| Negative Control | Down-regulation of Skp2 expression inhibits invasion and lung metastasis in osteosarcoma | Sci Rep | shRNA | TR30013 |
| Negative Control | WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma | Theranostics | shRNA | TR30012 |
| Negative Control | BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells | Mol Ther Nucleic Acids | shRNA | TR30015 |
| Negative Control | Involvement of an orphan transporter, SLC22A18, in cell growth and drug resistance of human breast cancer MCF7 cells | J Pharm Sci | shRNA | TR30012 |
| Negative Control | Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma | Oncogene | shRNA | TR30021 |
| Negative Control | CNTNAP2 stabilizes interneuron dendritic arbors through CASK | Mol. Psychiatry | shRNA | TR30013 |
| Negative Control | SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2 | bioRxiv | shRNA | TR30021 |
| Negative Control | Role of miR-31 and SATB2 in arsenic-induced malignant BEAS-2B cell transformation | Mol. Carcinog. | shRNA | TR30013 |
| Negative Control | Fluorescence Fluctuation Spectroscopy Reveals Differential SUN Protein Oligomerization In Living Cells | Mol. Biol. Cell | shRNA | TR30015 |
| Negative Control | Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells | Cell Death Dis | shRNA | TR30015 |
| Negative Control | Knockdown of ZEB1 suppressed the formation of vasculogenic mimicry and epithelial-mesenchymal transition in the human breast cancer cell line MDA-MB-231 | Mol Med Rep | shRNA | TR30021 |
| Negative Control | Reduced N-Type Ca2+Channels in Atrioventricular Ganglion Neurons Are Involved in Ventricular Arrhythmogenesis | J Am Heart Assoc | shRNA | TR30021 |
| Negative Control | Sphingosine 1-phosphate regulates proliferation, cell cycle and apoptosis of hepatocellular carcinoma cells via syndecan-1 | Prog. Biophys. Mol. Biol.2017 | shRNA | TR30021 |
| Negative Control | Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy | Autophagy | shRNA | TR30013 |
| Negative Control | Innate sensing of influenza A virus hemagglutinin glycoproteins by the host endoplasmic reticulum (ER) stress pathway triggers a potent antiviral response via ER-associated protein degradation | J. Virol. | shRNA | TR30021 |
| Negative Control | Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease | Aging Cell | shRNA | TR30013 |
| Negative Control | An E2F1/MiR-17-92 Negative Feedback Loop mediates proliferation of Mouse Palatal Mesenchymal Cells | Sci Rep | shRNA | TR30013 |
| Negative Control | RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5 | PLoS ONE | shRNA | TR30003 |
| Negative Control | Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas | J. Clin. Invest | shRNA | TR30013 |
| Negative Control | Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination | Nat Commun | shRNA | TR30021 |
| Negative Control | Hyperglycemia-induced Changes in ZIP7 and ZnT7 Expression Cause Zn(2+) Release from the Sarco(endo)plasmic Reticulum and Mediate ER-stress in the Heart | Diabetes | shRNA | TR30033 |
| Negative Control | PLA2G16 represents a switch between entry and clearance of Picornaviridae | Nature | shRNA | TR30013 |
| Negative Control | Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration | Nat Commun | shRNA | TR30021 |
| Negative Control | Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells | Mol Med Rep | shRNA | TR30013 |
| Negative Control | DNA damage response defect in Williams‑Beuren syndrome | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | shRNA | TR30013 |
| Negative control | Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation | EMBO J. | shRNA | TR30015 |
| Negative Control | Silencing peroxiredoxin-2 sensitizes human colorectal cancer cells to ionizing radiation and oxaliplatin | Cancer Lett | shRNA | TR30015 |
| negative control | Identification of CTCF as a master regulator of the clustered protocadherin genes | Nucleic Acids Res., Dec 2011; 10.1093/nar/gkr1260. | shRNA | |
| NEIL1 | Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase | J. Biol. Chem., Jan 2009; 10.1074/jbc.M807006200. | shRNA | TR307276 |
| NEK3 | Identification of NEK3 Threonine 165 as a Novel Regulatory Phosphorylation Site that Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration | J. Biol. Chem. | shRNA | TF320430 |
| NES | Identification and Cytoprotective Function of a Novel Nestin Isoform, Nes-S, in Dorsal Root Ganglia Neurons | J. Biol. Chem., Mar 2013; 288: 8391 - 8404. | shRNA | TR311207 |
| Neurod1 | MiR-30a-5p and miR-153-3p regulate LPS-induced neuroinflammatory response and neuronal apoptosis by targeting NeuroD1 | BMB Reports | shRNA | TL710234 |
| NF2 | Expression of P2X7 Receptor Increases In Vivo Tumor Growth | Cancer Res., Jun 2012; 72: 2957 - 2969. | shRNA | TR316639 |
| NFATC1 | TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways | Sci Rep | shRNA | TG302973 |
| NFATC2 | NFATC2 Modulates Radiation Sensitivity in Dermal Fibroblasts From Patients With Severe Side Effects of Radiotherapy | Frontiers in Oncology | shRNA | TF311198 |
| NFATC2 | An actionable axis linking NFATc2 to EZH2 controls the EMT-like program of melanoma cells | Oncogene | shRNA | TF311198 |
| Nfatc2 | Transcriptional regulation of SPROUTY 2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3 | Leukemia | shRNA | TG516359 |
| NFATC2 | NFATc2 is an intrinsic regulator of melanoma dedifferentiation | Oncogene | shRNA | TF311198 |
| NFATC2 | NFAT Targets Signaling Molecules to Gene Promoters in Pancreatic ß Cells | Mol. Endocrinol. | shRNA | TG516359 |
| NFATC2 | CD3-T Cell Receptor Co-stimulation through SLAMF3 and SLAMF6 Receptors Enhances RORt Recruitment to the IL17A Promoter in Human T Lymphocytes | J. Biol. Chem., Nov 2012; 287: 38168 - 38177. | shRNA | TG311198 |
| NFE2L2 | Effect of the Nrf2-ARE signaling pathway on biological characteristics and sensitivity to sunitinib in renal cell carcinoma | Oncol Lett | shRNA | TG311194 |
| NFE2L2 | Oxidative stress-elicited YY1 potentiates antioxidative response via enhancement of NRF2-driven transcriptional activity: A potential neuronal defensive mechanism against ischemia/reperfusion cerebral injury | Biomed. Pharmacother. | shRNA | TR515053 |
| NFE2L2 | Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane | Toxicol. Appl. Pharmacol. | shRNA | TG311194 |
| NFE2L2 | Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells | J. Biol. Chem | shRNA | TG311194 |
| NFE2L2 | Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells | Toxicol. Appl. Pharmacol. | shRNA | TG311194 |
| Nfe2l2 | 1,4-Naphthoquinone, a pro-oxidant, ameliorated radiation induced gastro-intestinal injury through perturbation of cellular redox and activation of Nrf2 pathway | Drug Discov Ther | shRNA | TF515053 |
| NFE2L2 | Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis | J. Biol. Chem. | shRNA | TG311194 |
| NFE2L2 | ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell | Int. J. Biol. Sci. | shRNA | TG311194 |
| NFKB1 | Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis | MBio | shRNA | TR318700 |
| NFKB1 | Leptin pro-angiogenic signature in breast cancer is linked to IL-1 signalling | British Journal of Cancer 104, 128-137 (7 December 2010) doi:10.1038/sj.bjc.6606013 Full Pape | shRNA | TR516641 |
| NIT1 | A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/ß-catenin signalling pathway | Cell Discovery | shRNA | TG311168 |
| NKD2 | Naked2 Acts as a Cargo Recognition and Targeting Protein to Ensure Proper Delivery and Fusion of TGF-{alpha}-containing Exocytic Vesicles at the Lower Lateral Membrane of Polarized MDCK Cells | Mol Biol Cell. 2007 Aug;18(8):3081-93. | shRNA | TR302950 |
| NKX2-5 | Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome | PLoS ONE July 2014 | shRNA | TR311165 |
| Nlgn2 | Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility | Proceedings of the National Academy of Sciences of the United States of America | shRNA | TG516880 |
| NLK | Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells | Cell Rep | shRNA | TF501483 |
| NLRP1 | NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma | Oncogene | shRNA | TG303052 |
| NLRP3 | Contribution of cathepsin B-dependent Nlrp3 inflammasome activation to nicotine-induced endothelial barrier dysfunction | Eur. J. Pharmacol. | shRNA | TG510752 |
| NLRP3 | Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3 inflammasome activation | Immunobiology | shRNA | TR510752 |
| NLRP3 | Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation | Oncotarget | shRNA | TG510752 |
| NLRP3 | Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death | Sci Rep | shRNA | TG305382 |
| Nlrp3 | Inhibition of Hyperhomocysteinemia-Induced Inflammasome Activation and Glomerular Sclerosis by NLRP3 Gene Deletion | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | shRNA | TG510752 |
| NLRP3 | Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1 | J. Cell. Mol. Med. | shRNA | TG510752 |
| NLRP3 | Gene silencing of NLRP3 protects against the sepsis-induced hyper -bileacidemia in a rat model | Clin. Exp. Immunol. | shRNA | TG305382 |
| NLRP3 | Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1ß Secretion | J. Virol., Dec 2011; 85: 13019 - 13026. | shRNA | TR305382 |
| NLRP3 | Francisella tularensis Reveals a Disparity between Human and Mouse NLRP3 Inflammasome Activation | J. Biol. Chem., Nov 2011; 286: 39033 - 39042. | shRNA | TR305382 |
| NLRX1 | Nlrx1 regulates neuronal cell death | Mol Brain | shRNA | TG515304 |
| NME2 | Promoter-proximal transcription factor binding is transcriptionally active when coupled with nucleosome repositioning in immediate vicinity | Nucleic Acids Res. July 2014 | shRNA | TR311160 |
| NMRK2 | SNARE-dependent interaction of Src, EGF receptor and β1 integrin regulates invadopodium formation and tumour cell invasion | J. Cell. Sci., Feb 2014. | shRNA | TF315677 |
| NMS | Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migration | FASEB J. | shRNA | TG311156 |
| Nod1 | Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses | Cancer research | shRNA | TL511305 |
| NOD1 | Cdx2 expression and intestinal metaplasia induced by H. pylori infection of gastric cells is regulated by NOD1-mediated innate immune responses | Cancer Res. | shRNA | TG511305 |
| NODAL | Cancer-associated fibroblasts promote PD-L1 expression in mice cancer cells via secreting CXCL5 | Int. J. Cancer | shRNA | TG501492 |
| NODAL | Endogenous Nodal promotes melanoma undergoing epithelial-mesenchymal transition via Snail and Slug in vitro and in vivo | Am J Cancer Res | shRNA | TG501492 |
| NODAL | Nodal promotes the generation of M2-like macrophages and downregulates the expression of IL-12 | Eur J Immunol. 2013 Oct 1. | shRNA | TG302929 |
| NOLC1 | Tissue-specific Gene Targeting by the Multiprotein Mammalian DREAM Complex | J. Biol. Chem., Aug 2011; 286: 27867 - 27871. | shRNA | TR311147 |
| Non-effective 29-mer Scrambled shRNA | The role of the ATPase inhibitor factor 1 (IF1) in cancer cells adaptation to hypoxia and anoxia | Biochimica et Biophysica Acta (BBA) - Bioenergetics | shRNA | TR30013 |
| Non-effective Control | Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer | Biochem. Biophys. Res. Commun. | shRNA | TR30012 |
| Non-Effective GFP | RhoC regulates actin remodeling to form phagosomes during FcγR-mediated phagocytosis | J. Cell. Sci.2017 | shRNA | TR30008 |
| NONO | p54nrb/NONO Regulates cAMP-dependent Glucocorticoid Production by Modulating Phosphodiesterase mRNA Splicing and Degradation | Mol. Cell. Biol. | shRNA | TG311143 |
| NOS1 | Sarcolemmal loss of active nNOS (Nos1) is an oxidative stress-dependent, early event driving disuse atrophy | J. Pathol. | shRNA | TG711710 |
| Nos1ap | Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice. | Science advances | shRNA | TL511126 |
| NOS2 | Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania | PeerJ | shRNA | TR709254 |
| Nos2 | Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype | Nat. Immunol. | shRNA | TR512302 |
| NOS2 | Apoptotic Programs Are Determined during Lineage Commitment of CD4+ T Effectors: Selective Regulation of T Effector-Memory Apoptosis by Inducible Nitric Oxide Synthase | J. Immunol., Jan 2013; 190: 97 - 105. | shRNA | TG512302 |
| Notch1 | Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells | Elife | shRNA | TG513589 |
| NOTCH1 | Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome | PLoS ONE July 2014 | shRNA | TR302916 |
| NOTCH2 | NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells | Oncol. Rep. | shRNA | TR302915 |
| NOTCH2 | Short hairpin RNA targeting Notch2 inhibits U87 human glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo | Mol Med Rep | shRNA | TG302915 |
| Notch2 | Short hairpin RNA targeting Notch2 inhibits U87 human glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo | Molecular Medicine Reports | shRNA | TL711020 |
| Notch3 | Notch3 is necessary for neuronal differentiation and maturation in the adult spinal cord | J. Cell. Mol. Med. | shRNA | TR515445 |
| NOVA1 | Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC- DLBCL cells in vitro and in vivo | Molecular cancer therapeutics | shRNA | TF311136 |
| NOX1 | Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis. | Free radical biology & medicine | shRNA | TG311135 |
| NOX1 | Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway | Eur Rev Med Pharmacol Sci | shRNA | TF311135 |
| Nox1 | NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | shRNA | TL514988 |
| NOX1 | NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | shRNA | TL311135 |
| NOX3 | Targeting tyrosine kinase inhibitor resistant non-small-cell lung cancer by inducing EGFR degradation via methionine 790 oxidation | Antioxid. Redox Signal. | shRNA | TG302912 |
| NOX4 | Guidelines for the Detection of NADPH Oxidases by Immunoblot and RT-qPCR | Methods in molecular biology (Clifton, N.J.) | shRNA | TG302911 |
| NOXA1 | Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo | Mol. Cancer Ther., May 2012; 11: 1122 - 1132. | shRNA | TR311134 |
| NP100005 | NRP-1 expression is strongly associated with the progression of pituitary adenomas | Oncol. Rep. | shRNA | TR30019 |
| NP100041 | Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells | Br. J. Cancer July 2014 | shRNA | TR20003 |
| Npr3 | NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF-a | Cell Cycle | shRNA | TR709485 |
| Nprl3 | DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons | Neurobiol. Dis. | shRNA | TG501301 |
| NQO2 | Control of stability of cyclin D1 by quinone reductase 2 in CWR22Rv1 prostate cancer cells | Carcinogenesis, Mar 2012; 33: 670 - 677. | shRNA | TR311108 |
| Nr1h3 | Regulation of Insulin Resistance and Adiponectin Signaling in Adipose Tissue by Liver X Receptor Activation Highlights a Cross-Talk with PPAR? | PLoS ONE | shRNA | TG502381 |
| NR1H4 | Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells | BMC Cancer | shRNA | TG320627 |
| NR1H4 | Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling | PLoS ONE | shRNA | TG320627 |
| NR1I2 | Effects of silenced PAR-2 on cell proliferation, invasion and metastasis of esophageal cancer | Oncology Letters | shRNA | TG320596 |
| NR1I2 | Pregnane X Receptor As a Therapeutic Target to Inhibit Androgen Activity | Endocrinology, Oct 2010; 10.1210/en.2010-0708 | shRNA | TR320596 |
| NR2F2 | Oncogenic KRAS signaling activates mTORC1 through COUP-TFII-mediated lactate production | EMBO Rep. | shRNA | TR320548 |
| NR4A1 | Dendrogenin A drives LXR to trigger lethal autophagy in cancers | Nat Commun | shRNA | TG514239 |
| NR4A1 | Chymase Mediates Injury and Mitochondrial Damage in Cardiomyocytes during Acute Ischemia/Reperfusion in the Dog | PLoS ONE e94732 9 4. April 2014 | shRNA | TG320381 |
| NR4A3 | Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths | Cell Rep | shRNA | TF501493 |
| Nr4a3 | Dendrogenin A drives LXR to trigger lethal autophagy in cancers | Nat Commun | shRNA | TF501493 |
| NR5A1 | cAMP-stimulated transcription of DGK{theta} requires steroidogenic factor 1 and sterol regulatory element binding protein 1 | J. Lipid Res., Aug 2013; 54: 2121 - 2132. | shRNA | TG311103 |
| NRAS | The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation | Cell Rep | shRNA | TR712458 |
| NRF1 | Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells | Toxicol. Appl. Pharmacol. | shRNA | TR311098 |
| NRIP1 | New Target Genes in Endometrial Tumors Show a Role for the Estrogen-Receptor Pathway in Microsatellite Unstable Cancers | Hum. Mutat. | shRNA | TG311094 |
| NRP1 | Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2+ Cells | Dev. Cell | shRNA | TG513573 |
| NRP1 | Neuropilin1 is an important niche component and exerts context-dependent effects on hematopoietic stem cells | Stem Cells Dev. | shRNA | TR513573 |
| NRP1 | NRP-1 expression is strongly associated with the progression of pituitary adenomas | Oncol. Rep. | shRNA | TR311093 |
| NRP1 | The Plexin-A1 Receptor Activates Vascular Endothelial Growth Factor-Receptor 2 and Nuclear Factor-B to Mediate Survival and Anchorage-Independent Growth of Malignant Mesothelioma Cells | Cancer Res., Feb 2009; 69: 1485 - 1493 | shRNA | TR311093 |
| Nsd2 | The Histone Methyltransferase MMSET Regulates Class Switch Recombination | J. Immunol., Jan 2013; 190: 756 - 763. | shRNA | TF517851 |
| NSUN5 | RNA cytosine methyltransferase NSUN5 promotes protein synthesis and tumorigenic phenotypes in glioblastoma. | Molecular oncology | shRNA | TL302876 |
| Nt5e | Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis | PNAS, Jan 2010; 107: 1547 - 1552 | shRNA | TR515992 |
| Ntf4 | PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise | Cell metabolism | shRNA | TF709774 |
| NTRK1 | Safrole oxide induces human umbilical vein endothelial cell transdifferentiation to 5-hydroxytryptaminergic neuron-like cells through tropomyosin receptor kinase A/cyclooxygenase 2/nuclear factor-kappa B/interleukin 8 signaling. | The international journal of biochemistry & cell biology | shRNA | TR320435 |
| NTRK1 | Effect of Brain- and Tumor-Derived Connective Tissue Growth Factor on Glioma Invasion | J Natl Cancer Inst, Aug 2011; 103: 1162 - 1178. | shRNA | TR320435 |
| Ntrk2 | BDNF repairs podocyte damage by microRNA-mediated increase of actin polymerization | J. Pathol. | shRNA | TR510739 |
| NTRK2 | TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma | Oncogene (18 January 2010) doi:10.1038/onc.2009.486 Original Article | shRNA | TR320436 |
| NUCB2 | Nucleobindin-2 is a positive regulator for insulin-stimulated glucose transporter 4 translocation in fenofibrate treated E11 podocytes [Rapid Communication] | Endocr. J. | shRNA | TR502933 |
| Nucb2 | Nucleobindin-2 Is a Positive Modulator of EGF-Dependent Signals Leading to Enhancement of Cell Growth and Suppression of Adipocyte Differentiation | Endocrinology, Jul 2012; 153: 3308 - 3319. | shRNA | TR502933 |
| Nudt1 | MTH1 favors mesothelioma progression and mediates paracrine rescue of bystander endothelium from oxidative damage | JCI Insight | shRNA | TL501390 |
| NUMA1 | The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair | Nucleic Acids Res. | shRNA | TR311065 |
| NUMB | NUMB and NUMBL differences in gene regulation | Oncotarget | shRNA | TR311064 |
| NUMB | The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB | Clin. Cancer Res | shRNA | TR311064 |
| Numb | Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy | Oncotarget | shRNA | TR311064 |
| NUMB | Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy | J. Physiol. Biochem. | shRNA | TR311064 |
| NUMBL | NUMB and NUMBL differences in gene regulation | Oncotarget | shRNA | TR311063 |
| NumbL | Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy | Oncotarget | shRNA | TR311063 |
| ODAM | ODAM inhibits RhoA-dependent invasion in breast cancer | Cell Biochem. Funct. | shRNA | TG307066 |
| OGA | Epithelial mesenchymal transition induces aberrant glycosylation through hexosamine biosynthetic pathway activation | J. Biol. Chem. | shRNA | TG315637 |
| OGT | The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis | Nat Commun | shRNA | TG302811 |
| OGT | Epithelial mesenchymal transition induces aberrant glycosylation through hexosamine biosynthetic pathway activation | J. Biol. Chem. | shRNA | TG302811 |
| OLR1 | Lectin-like oxidized LDL receptor-1 expresses in mouse bone marrow-derived mesenchymal stem cells and stimulates their proliferation. | Experimental cell research | shRNA | TL311028 |
| OMA1 | Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells | Sci Rep | shRNA | TR302802 |
| OMA1 | OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury | Am. J. Physiol. Renal Physiol. . March 2014 | shRNA | TR302802 |
| OR51E1 | Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line | The Journal of biological chemistry | shRNA | TR302775 |
| ORAI1 | Arachidonic acid-induced Ca2+entry and migration in a neuroendocrine cancer cell line | Cancer Cell Int. | shRNA | TF301009 |
| ORAI1 | Molecular mechanisms of spontaneous and directed mast cell motility | J. Leukoc. Biol., Nov 2012; 92: 1029 - 1041. | shRNA | TG301009 |
| ORAI1 | Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration | FASEB J, Apr 2009; 10.1096/fj.09-131128. | shRNA | TR301009 |
| Orai1 | Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line | J. Immunol., Feb 2008; 180: 2233 - 2239. | shRNA | TR301009 |
| ORAI2 | Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration | FASEB J, Apr 2009; 10.1096/fj.09-131128. | shRNA | TR301008 |
| ORAI3 | Arachidonic acid-induced Ca2+entry and migration in a neuroendocrine cancer cell line | Cancer Cell Int. | shRNA | TF307587 |
| ORAI3 | Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration | FASEB J, Apr 2009; 10.1096/fj.09-131128. | shRNA | TR307587 |
| OSBPL2 | Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis | Mol. Cell. Endocrinol. | shRNA | TG310662 |
| OSBPL9 | Odd-skipped related 1 is a novel tumour suppressor gene and a potential prognostic biomarker in gastric cancer | The Journal of Pathology | shRNA | TG302749 |
| OSR1 | Odd-skipped related 1 is a novel tumor suppressor gene and a potential prognostic biomarker in gastric cancer | J. Pathol. | shRNA | TG302745 |
| P4HB | Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways | Neuro Oncology, May 2013; 15: 562 - 577. | shRNA | TR310639 |
| P4HB | Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure | Blood, Aug 2010; 116: 993 - 1001 | shRNA | TR310639 |
| PABPC4 | The Cytoplasmic poly(A) Binding Protein, PABPC4, Serves a Critical Role in Erythroid Differentiation | Mol. Cell. Biol., Jan 2014. | shRNA | TG510913 |
| Padi4 | Citrullination regulates pluripotency and histone H1 binding to chromatin | Nature, Feb 2014. | shRNA | TF501611 |
| PAF1 | A role for the RNA pol II–associated PAF complex in AID-induced immune diversification | J. Exp. Med., Oct 2012; 209: 2099 - 2111. | shRNA | TG302706 |
| PAF1 | A role for the RNA pol II–associated PAF complex in AID-induced immune diversification | J. Exp. Med., Sep 2012; 10.1084/jem.20112145. | shRNA | TR302706 |
| PAK1 | Modulation of store-operated calcium entry and nascent adhesion by p21-activated kinase 1 | Exp. Mol. Med. | shRNA | TF320442 |
| PAK1 | Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis | Cell Rep | shRNA | TG501572 |
| PAK1 | P21 Activated Kinase-1 (Pak1) Promotes Prostate Tumor Growth and Microinvasion via Inhibition of Transforming Growth Factor ß Expression and Enhanced Matrix Metalloproteinase 9 Secretion | J. Biol. Chem., Feb 2013; 288: 3025 - 3035. | shRNA | TG320442 |
| PAK2 | Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinase Exerts Synergistic Effect against Chronic Myeloid Leukemia Cells | Cancers (Basel) 2019 | shRNA | TF506650 |
| PAK4 | p21-Activated kinase 4 promotes prostate cancer progression through CREB | Oncogene doi:10.1038/onc.2012.255 | shRNA | TR320637 |
| PAK4 | p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients | PNAS, Oct 2010; 107: 18622 - 18627 | shRNA | TR320637 |
| PAK6 | P21 Activated Kinase-1 (Pak1) Promotes Prostate Tumor Growth and Microinvasion via Inhibition of Transforming Growth Factor ß Expression and Enhanced Matrix Metalloproteinase 9 Secretion | J. Biol. Chem., Feb 2013; 288: 3025 - 3035. | shRNA | TF320717 |
| PALB2 | PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2 | Mol. Cancer Res., Jul 2009; 7: 1110 - 1118. | shRNA | TR307284 |
| Pam16 | Magmas, a Gene Newly Identified as Overexpressed in Human and Mouse ACTH-Secreting Pituitary Adenomas, Protects Pituitary Cells from Apoptotic Stimuli | Endocrinology, Oct 2010; 151: 4635 - 4642 | shRNA | TR513987 |
| PANX1 | High PANX1 Expression Leads to Neutrophil Recruitment and the Formation of a High Adenosine Immunosuppressive Tumor Microenvironment in Basal-like Breast Cancer | Cancers | shRNA | TF302694 |
| PANX1 | Pannexin 1 binds β-catenin to modulate melanoma cell growth and metabolism | The Journal of biological chemistry | shRNA | TR302694 |
| PANX1 | Pannexin 1 binds β-catenin to modulate melanoma cell growth and metabolism | The Journal of Biological Chemistry | shRNA | TL302694 |
| PANX1 | Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells | Cancers (Basel) 2019 | shRNA | TR302694 |
| PANX1 | Loss of Pannexin 1 Attenuates Melanoma Progression by Reversion to a Melanocytic Phenotype | J. Biol. Chem., Aug 2012; 287: 29184 - 29193. | shRNA | TR302694 |
| PANX1 | The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes | J. Biol. Chem., Jul 2009; 284: 18143 - 18151 | shRNA | TR302694 |
| PANX3 | Pannexin 3 regulates skin development via Epiprofin | Scientific Reports | shRNA | TG302692 |
| PANX3 | Characterization and Function of the~ 70 kDa Immunoreactive Species of Pannexin3 in Rhabdomyosarcomas | Thesis | shRNA | TF302692 |
| Panx3 | Pannexin 1 and Pannexin 3 Channels Regulate Skeletal Muscle Myoblast Proliferation and Differentiation | J. Biol. Chem. | shRNA | TF302692 |
| PARD3 | Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway | J. Exp. Clin. Cancer Res. | shRNA | TR302678 |
| Parp1 | Poly(ADP-ribose) Polymerase 1 Mediates Rab5 Inactivation after DNA Damage | International Journal of Molecular Sciences | shRNA | TL509117 |
| PARP1 | Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1 | PLoS Pathog. | shRNA | TR315488 |
| PARP1 | The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1 | PLoS Genet. | shRNA | TG315488 |
| PARP1 | Poly(ADP-ribose) Contributes to an Association between Poly(ADP-ribose) Polymerase-1 and Xeroderma Pigmentosum Complementation Group A in Nucleotide Excision Repair | J. Biol. Chem., Nov 2012; 287: 39824 - 39833. | shRNA | TG315488 |
| PARP1 | Thrombomodulin Is Silenced in Malignant Mesothelioma by a Poly(ADP-ribose) Polymerase-1-mediated Epigenetic Mechanism | J. Biol. Chem., Jun 2011; 286: 19478 - 19488 | shRNA | TR315488 |
| PARP1 | Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression | Blood, Mar 2011; 117: 2891 - 2900 | shRNA | TR315488 |
| ParvB | Expression of parvin-ß is a prognostic factor for patients with urothelial cell carcinoma of the upper urinary tract | British Journal of Cancer 103, 852-860 (24 August 2010) doi:10.1038/sj.bjc.6605835 Full Paper | shRNA | TR310602 |
| PATE4 | shRNA mediated ablation of prostate and testis expressed (Pate) messenger RNA results in impaired sperm function and fertility | Andrology | shRNA | TG707288 |
| PAX5 | PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene | Gene | shRNA | TG302663 |
| PAX6 | Pax6 Regulates the Expression of Dkk3 in Murine and Human Cell Lines, and Altered Responses to Wnt Signaling Are Shown in FlpIn-3T3 Cells Stably Expressing Either the Pax6 or the Pax6(5a) Isoform | PLoS ONE July 2014 | shRNA | TG310597 |
| Pbx3 | PBX3 is an important cofactor of HOXA9 in leukemogenesis | Blood, Feb 2013; 121: 1422 - 1431. | shRNA | TG310590 |
| PCBP1 | PolyC-binding proteins enhance expression of the CDK2 cell cycle regulatory protein via alternative splicing | Nucleic Acids Res. | shRNA | TG310588 |
| PCBP1 | PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase. | Cancer cell | shRNA | TG310588 |
| Pcdh17 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death | Signal Transduction and Targeted Therapy | shRNA | TL705847 |
| PCDH7 | PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function | Sci Rep | shRNA | TR700521 |
| PCLO | Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms | Sci Rep | shRNA | TF502633 |
| pCMVENTRY | Kinesin KIF4A transports integrin ß1 in developing axons of cortical neurons | Mol. Cell. Neurosci. | shRNA | TR30013 |
| PCMVMIR | Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells | Nature July 2014 | shRNA | TR30021 |
| PCSK5 | Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing | PLoS ONE, Jan 2014. | shRNA | TF310565 |
| PCSK7 | Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing | PLoS ONE, Jan 2014. | shRNA | TF310564 |
| PCSK9 | ß-Estradiol Results in a PCSK9-Dependent Increase in LDLR Levels in Human Hepatic HuH7 Cells | FEBS J. | shRNA | TG302581 |
| PCTM1 | The MicroRNA 15a/16–1 Cluster Down-regulates Protein Repair Isoaspartyl Methyltransferase in Hepatoma Cells: IMPLICATIONS FOR APOPTOSIS REGULATION | J. Biol. Chem., Dec 2011; 286: 43690 - 43700. | shRNA | |
| PDCD4 | Expression of TRPM8 in human reactive lymphoid tissues and mature B-cell neoplasms | Oncol Lett | shRNA | TG302573 |
| PDCD4 | Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression | Anat Rec (Hoboken) 2018 | shRNA | TG302573 |
| PDCD4 | MicroRNA-429 sensitizes pancreatic cancer cells to gemcitabine through regulation of PDCD4 | Am J Transl Res | shRNA | TG302573 |
| PDCD6 | ALG2 Influences T cell apoptosis by regulating FASLG intracellular transportation | Biochem. J. | shRNA | TG310558 |
| PDCD6 | Apoptosis-linked gene 2 promotes breast cancer growth and metastasis by regulating the cytoskeleton | Oncotarget | shRNA | TG310558 |
| PDCD6 | Structural and Functional Study of Apoptosis-linked Gene-2/Heme-binding Protein 2 Interactions in HIV-1 Production | J. Biol. Chem. | shRNA | TR310558 |
| PDGFRA | PDGFRa Regulates Follicular Cell Differentiation Driving Treatment Resistance and Disease Recurrence in Papillary Thyroid Cancer | EBioMedicine | shRNA | TR310535 |
| PDGFRA | Culture dimensionality influences the resistance of glioblastoma stem-like cells to multikinase inhibitors | Mol. Cancer Ther. April 2014 | shRNA | TR310535 |
| PDGFRB | Primary breast cancer cell culture yields intra-tumor heterogeneous subpopulations expressing exclusive patterns of receptor tyrosine kinases | BMC Cancer | shRNA | TG310534 |
| PDIA2 | Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum | The EMBO Journal 29, 4185-4197 (5 November 2010) doi:10.1038/emboj.2010.273 Article | shRNA | TR310528 |
| PDK1 | Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions | Cell Rep | shRNA | TR517458 |
| PDK1 | HMGB1 Is Phosphorylated by Classical Protein Kinase C and Is Secreted by a Calcium-Dependent Mechanism | J. Immunol., May 2009; 182: 5800 - 5809. | shRNA | TR320448 |
| PDK1 | Targeting Endoplasmic Reticulum Stress and Akt with OSU-03012 and Gefitinib or Erlotinib to Overcome Resistance to Epidermal Growth Factor Receptor Inhibitors | Cancer Res., Apr 2008; 68: 2820 - 2830 | shRNA | TR320448 |
| PDK2 | Retinoic acid-related orphan receptor alpha reprograms glucose metabolism in glutamine-deficient hepatoma cells | Hepatology | shRNA | TR320449 |
| PDK4 | Identification of ERR alpha as a specific partner of PGC-1 alpha for the activation of PDK4 gene expression in muscle | FEBS J., Apr 2006; 273: 1669-1680. | shRNA | TR320451 |
| Per1 | Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK. | Journal of neurochemistry | shRNA | TL501619 |
| Per1 | Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK | J. Neurochem. | shRNA | TG501619 |
| PERP | PERP, a p53 pro-apoptotic target, mediates apoptotic cell death in renal ischemia | Am J Physiol Renal Physiol, Jan 2009; 10.1152/ajprenal.90438.2008. | shRNA | TR302542 |
| PEX5 | A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS | Nature Cell Biology doi:10.1038/ncb2822 | shRNA | TG310491 |
| Pfkfb3 | Differential role of neuronal glucose and PFKFB3 in memory formation during development. | Glia | shRNA | TL712366 |
| PFKFB3 | A ROLE FOR PFKFB3/IPFK2 IN OVERNUTRITION-ASSOCIATED ADIPOSE TISSUE AND INTESTINE INFLAMMATORY RESPONSES AND INSULIN RESISTANCE | Thesis | shRNA | TR517196 |
| PFKFB3 | Disruption of Inducible 6-Phosphofructo-2-kinase Ameliorates Diet-induced Adiposity but Exacerbates Systemic Insulin Resistance and Adipose Tissue Inflammatory Response | J. Biol. Chem., Feb 2010; 285: 3713 - 3721 | shRNA | TR517196 |
| PGAM2 | Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase | Cancer Res. | shRNA | TG310477 |
| Pgam5 | A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy | Redox Biology | shRNA | TR702898 |
| Pgap2 | Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival | eLife | shRNA | TL507043 |
| pGFP-C-shLenti | Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons | Neuroscience | shRNA | TR30021 |
| PHF1 | Polycomb Group Protein PHF1 Regulates p53-dependent Cell Growth Arrest and Apoptosis | J. Biol. Chem., Jan 2013; 288: 529 - 539. | shRNA | TG302514 |
| PHLPP1 | Oncogenic suppression of PHLPP1 in human melanoma. | Oncogene | shRNA | TL302501 |
| PI3K | Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival | Mol. Cell. Biol., Mar 2011; 10.1128/MCB.01313-10 | shRNA | |
| PIEZO1 | Piezo1 activation facilitates ovarian cancer metastasis via Hippo/YAP signaling axis | Channels | shRNA | TF313084 |
| PIEZO2 | A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons | Sci Rep | shRNA | TR509519 |
| PIK3C2A | Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan | Nature Communications | shRNA | TL310432 |
| Pik3c3 | Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinase Exerts Synergistic Effect against Chronic Myeloid Leukemia Cells | Cancers | shRNA | TF506698 |
| Pik3c3 | Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells | Elife | shRNA | TG506698 |
| PIK3C3 | pp60c-Src Phosphorylates and Activates Vacuolar Protein Sorting 34 to Mediate Cellular Transformation | Cancer Res., Jul 2010; 70: 5974 - 5983 | shRNA | TR310429 |
| Pik3ca | Phosphoinositide 3-kinase beta controls replication factor C assembly and function | Nucleic Acids Res., Jan 2013; 41: 855 - 868. | shRNA | TG501641 |
| PIK3CB | Nuclear phosphoinositide 3-kinase ß controls double-strand break DNA repair | PNAS, Apr 2010; 107: 7491 - 7496 | shRNA | TR310427 |
| Pik3cb | Specific function of phosphoinositide 3-kinase beta in the control of DNA replication | Proceedings of the National Academy of Sciences of the United States of America | shRNA | TF711892 |
| PIK3CB | Specific function of phosphoinositide 3-kinase beta in the control of DNA replication | PNAS, May 2009; 106: 7525 - 7530. | shRNA | TR310427 |
| Pik3r1 | Phosphoinositide 3-kinase beta controls replication factor C assembly and function | Nucleic Acids Res., Nov 2012; 10.1093/nar/gks1095. | shRNA | TG509680 |
| PIK3R1 | p85ß phosphoinositide 3-kinase subunit regulates tumor progression | PNAS, Jun 2012; 10.1073/pnas.1118138109. | shRNA | TR307821 |
| PIM1 | miR24-2 accelerates progression of liver cancer cells by activating Pim1 through tri-methylation of Histone H3 on the ninth lysine | J. Cell. Mol. Med. | shRNA | TF315503 |
| PIM1 | HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372 | Oncotarget | shRNA | TG315503 |
| PINK1 | Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys | Autophagy | shRNA | TR705269 |
| PINK1 | Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy | J. Neurochem. | shRNA | TR320728 |
| PINK1 | Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission | J. Biol. Chem., May 2009; 284: 13843 - 13855. | shRNA | TR320728 |
| Pip5k1b | DNA damage causes rapid accumulation of phosphoinositides for ATR signaling | Nat Commun | shRNA | TF517012 |
| Pip5k1b | Acute and Temporal Expression of Tumor Necrosis Factor (TNF)-α-stimulated Gene 6 Product, TSG6, in Mesenchymal Stem Cells Creates Microenvironments Required for Their Successful Transplantation into Muscle Tissue | The Journal of Biological Chemistry | shRNA | TF517012 |
| PITX1 | Downregulated PITX1 Modulated by MiR-19a-3p Promotes Cell Malignancy and Predicts a Poor Prognosis of Gastric Cancer by Affecting Transcriptionally Activated PDCD5 | Cell. Physiol. Biochem. | shRNA | TG310405 |
| PIWIL2 | Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis | Oncotarget | shRNA | TG302470 |
| PKM | Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein | Viruses | shRNA | TG302462 |
| Pkm | Functional polarization of tumour-associated macrophages by tumour-derived lactic acid | Nature July 2014 | shRNA | TG511241 |
| Pla2g6 | H2O2-activated mitochondrial phospholipase iPLA2? prevents lipotoxic oxidative stress in synergy with UCP2, amplifies signaling via G-protein-coupled receptor GPR40, and regulates insulin secretion in pancreatic ß-cells | Antioxid. Redox Signal. | shRNA | TG700671 |
| Pla2g6 | Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development | FASEB J, Jun 2010; 10.1096/fj.10-161356 | shRNA | TR515018 |
| plasmid | Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4 | PNAS, Sep 2011; 108: 16098 - 16103. | shRNA | |
| PLCG1 | CCR7/CCL21 Migration on Fibronectin Is Mediated by Phospholipase C{gamma}1 and ERK1/2 in Primary T Lymphocytes | J. Biol. Chem., Dec 2010; 285: 38781 - 38787 | shRNA | TF302445 |
| Pld1 | Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP 3 -Evoked Ca 2+ Signals through Sigma-1 Receptors | Cell Reports | shRNA | TF711124 |
| Pld2 | Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP 3 -Evoked Ca 2+ Signals through Sigma-1 Receptors | Cell Reports | shRNA | TF711696 |
| PLD2 | Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment | Oncogene | shRNA | TR511484 |
| Pld3 | Rare coding variants in Phospholipase D3 (PLD3) confer risk for Alzheimer's disease | Nature | shRNA | TL501676 |
| PLD3 | Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease | Nature Dec 2013. | shRNA | TG310364 |
| PLD3 | Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease | Nature Dec 2013. | shRNA | TG501676 |
| PLK1 | PLK1 inhibition downregulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster | J. Biol. Chem. | shRNA | TG320457 |
| PLK1 | PLK1 Inhibitors Synergistically Potentiate HDAC Inhibitor Lethality in Imatinib Mesylate–Sensitive or –Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo | Clin. Cancer Res., Jan 2013; 19: 404 - 414. | shRNA | TG320457 |
| PLK1 | Centrosomal Protein 55 (Cep55) Stability Is Negatively Regulated by p53 Protein through Polo-like Kinase 1 (Plk1) | J. Biol. Chem., Feb 2012; 287: 4376 - 4385. | shRNA | TR320457 |
| PLOD3 | Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression | Mol. Cell. Probes | shRNA | TR310350 |
| PLPP3 | Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development | Cardiovasc. Res. | shRNA | TG302357 |
| Plpp6 | Role of Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2) In Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes | Drug Metab. Dispos. | shRNA | TR703334 |
| PLXNA1 | The Plexin-A1 Receptor Activates Vascular Endothelial Growth Factor-Receptor 2 and Nuclear Factor-B to Mediate Survival and Anchorage-Independent Growth of Malignant Mesothelioma Cells | Cancer Res., Feb 2009; 69: 1485 - 1493 | shRNA | TR302406 |
| Pmaip1 | Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation | Mucosal Immunol | shRNA | TR512752 |
| PMAIP1 | NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5 | Int. J. Oncol. | shRNA | TR318983 |
| Pnpla8 | H2O2-activated mitochondrial phospholipase iPLA2? prevents lipotoxic oxidative stress in synergy with UCP2, amplifies signaling via G-protein-coupled receptor GPR40, and regulates insulin secretion in pancreatic ß-cells | Antioxid. Redox Signal. | shRNA | TG706565 |
| PODXL | High Podocalyxin levels promote cell viability partially through up-regulation of Annexin A2 | Biochem. Biophys. Res. Commun. | shRNA | TG310316 |
| PODXL | Methylation of an intronic region regulates miR-199a in testicular tumor malignancy | Oncogene (7 March 2011) doi:10.1038/onc.2011.60 Original Article | shRNA | TR310316 |
| Pofut1 | Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation. | Analytical biochemistry | shRNA | TG506022 |
| POLD3 | Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney | Am J Physiol Renal Physiol, Dec 2012; 303: F1629 - F1640. | shRNA | TG310310 |
| PON1 | Paraoxonase-1 (PON1) induces metastatic potential and apoptosis escape via its antioxidative function in lung cancer cells | Oncotarget | shRNA | TR310286 |
| Positive Control | An integrated transcriptomics-guided genome-wide promoter analysis and next-generation proteomics approach to mine factor(s) regulating cellular differentiation | DNA Res | shRNA | TR30002 |
| POU1F1 | Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus | J. Clin. Invest. | shRNA | TG310279 |
| POU2F1 | Epigenetic events involved in OCT1-dependent impaired response of hepatocellular carcinoma to sorafenib | Br. J. Pharmacol. | shRNA | TF310277 |
| POU2F1 | Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal | Nature Communications | shRNA | TL310277 |
| POU2F3 | Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus | The Journal of Clinical Investigation | shRNA | TG310275 |
| POU5F1 | OCT4 accelerates tumorigenesis through activating JAK/STAT signaling in ovarian cancer side population cells | Cancer Manag Res | shRNA | TR310267 |
| POU5F1 | MiR-145 regulates cancer stem-like properties and epithelial-to-mesenchymal transition in lung adenocarcinoma-initiating cells | Tumour Biol. | shRNA | TF310267 |
| POU5F1 | OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation | Cell Death Dis, Jan 2014. | shRNA | TG310267 |
| PPARD | Exercise Training-Induced PPARβ Increases PGC-1α Protein Stability and Improves Insulin-Induced Glucose Uptake in Rodent Muscles | Nutrients | shRNA | TG501712 |
| PPARD | PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise | Cell Metab. | shRNA | TF709733 |
| PPARD | Changes in PPARδ expression in a rat model of stress-induced depression | Clin. Exp. Pharmacol. Physiol | shRNA | TR709733 |
| Ppard | Serine Carboxypeptidase SCPEP1 and Cathepsin A Play Complementary Roles in Regulation of Vasoconstriction via Inactivation of Endothelin-1 | PLoS Genetics | shRNA | TF501712 |
| Pparg | Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths | Cell reports | shRNA | TF510219 |
| PPARG | Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung | Biochem. Biophys. Res. Commun. | shRNA | TG510219 |
| PPARG | Activation of peroxisome proliferator-activated receptor a stimulates ADAM10-mediated proteolysis of APP | Proc. Natl. Acad. Sci. U.S.A. | shRNA | TG320459 |
| PPARG | TGFß can stimulate the p(38)/ß-catenin/PPAR? signaling pathway to promote the EMT, invasion and migration of non-small cell lung cancer (H460 cells) | Clin. Exp. Metastasis | shRNA | TR320459 |
| PPARGC1A | PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts | Genet. Mol. Biol. | shRNA | TG310260 |
| PPARGC1A | Genome-wide analyses of transcription factors and co-regulators across seven cohorts identified reduced PPARGC1A expression as a driver of prostate cancer progression | bioRxiv | shRNA | TG310260 |
| PPARGC1A | Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7 | Neuron | shRNA | TG310260 |
| PPARGC1A | c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer | Mol Oncol | shRNA | TR310260 |
| PPARGC1A | PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis | Nat. Cell Biol. | shRNA | TG310260 |
| Ppif | Cyclophilin D-induced mitochondrial impairment confers axonal injury after intracerebral hemorrhage in mice | Neural Regeneration Research | shRNA | TL713307 |
| PPP1R12A | Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness | Mol. Cancer | shRNA | TR310238 |
| PPP2CA | Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model | Br. J. Cancer | shRNA | TG310229 |
| PPP2R1A | Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors | Mod. Pathol. | shRNA | TR310227 |
| PPP4R2 | PATZ1 induces PP4R2 to form a negative feedback loop on IKK/NF-κB signaling in lung cancer | Oncotarget | shRNA | TF302311 |
| PRB1 | Transcriptional Activation by pRB and Its Coordination with SWI/SNF Recruitment | Cancer Res., Nov 2010; 70: 8282 - 8287 | shRNA | TR310199 |
| PRDX1 | Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication | Vaccine | shRNA | TG302287 |
| PRDX1 | Dithiol-based Compounds Maintain Expression of Antioxidant Protein Peroxiredoxin 1 That Counteracts Toxicity of Mutant Huntingtin | J. Biol. Chem., Jun 2012; 287: 22717 - 22729. | shRNA | TR302287 |
| PRDX2 | Silencing peroxiredoxin-2 sensitizes human colorectal cancer cells to ionizing radiation and oxaliplatin | Cancer Lett | shRNA | TR310194 |
| PRDX5 | Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma. | Oral diseases | shRNA | TL310192 |
| PRDX5 | Regulation of Reactive Oxygen Species Homeostasis by Peroxiredoxins and c-Myc | J. Biol. Chem., Mar 2009; 284: 6520 - 6529. | shRNA | TR503057 |
| PRDX6 | Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration | Free Radic. Biol. Med. | shRNA | TR310191 |
| pRFP-C-RS | Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats | Front Mol Neurosci | shRNA | TR30014 |
| PRKAA1 | DHFR/TYMS are positive regulators of glioma cell growth and modulate chemo-sensitivity to temozolomide | Eur. J. Pharmacol. | shRNA | TG320461 |
| PRKAA1 | Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release from the endoplasmic reticulum by AMP-activated kinase modulators | Cell Calcium | shRNA | TG320461 |
| PRKAA1 | Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity | Sci Rep | shRNA | TR505729 |
| PRKAA1 | Underactivation of the adiponectin-adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression | Clin Exp Metastasis. 2013 Oct 5 | shRNA | TG505729 |
| PRKAA2 | AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation | J. Cell. Sci. | shRNA | TG320462 |
| PRKAA2 | Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells | Breast Cancer Res. | shRNA | TF320462 |
| PRKAA2 | AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation | Am J Physiol Renal Physiol, Dec 2011; 301: F1177 - F1192. | shRNA | TR320462 |
| PRKAB1 | Reduced expression of AMPK-ß1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer | Mol. Cancer | shRNA | TG315591 |
| Prkca | Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology | Nat Commun | shRNA | TG501653 |
| PRKCA | Caveolin-1 promotes resistance to chemotherapy-induced apoptosis in Ewing's sarcoma cells by modulating PKC{ALPHA} phosphorylation | shRNA | TR320466 | |
| PRKCA | PCPH/ENTPD5 Expression Confers to Prostate Cancer Cells Resistance against Cisplatin-Induced Apoptosis through Protein Kinase C–Mediated Bcl-2 Stabilization | Cancer Res., Jan 2009; 69: 102 - 110. | shRNA | TR320466 |
| PRKCD | Protein Kinase C Delta restrains growth in ACTH-secreting pituitary adenoma cells | Mol. Cell. Endocrinol. | shRNA | TG513052 |
| PRKCD | Distinct ICD substrate modifications selectively regulate ectodomain cleavage of NRG1 or CD44 | Mol. Cell. Biol. | shRNA | TG320468 |
| PRKCD | Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281 | Cell. Signal. | shRNA | TR320468 |
| PRKCD | PKCd maintains phenotypes of tumor initiating cells through cytokine-mediated autocrine loop with positive feedback | Oncogene | shRNA | TG320468 |
| PRKCD | Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy | J. Cell. Physiol. | shRNA | TG513052 |
| PRKCD | miR-26a Plays an Important Role in Cell Cycle Regulation in ACTH-Secreting Pituitary Adenomas by Modulating Protein Kinase C | Endocrinology, May 2013; 154: 1690 - 1700. | shRNA | TG320468 |
| PRKCD | Sprouty2 Interacts with Protein Kinase C and Disrupts Phosphorylation of Protein Kinase D1 | J. Biol. Chem., Jul 2009; 284: 19623 - 19636 | shRNA | TR320468 |
| PRKCD | Connexin43 Potentiates Osteoblast Responsiveness to Fibroblast Growth Factor 2 via a Protein Kinase C-Delta/Runx2–dependent Mechanism | Mol. Biol. Cell, Jun 2009; 20: 2697 - 2708 | shRNA | TR320468 |
| PRKCD | PCPH/ENTPD5 Expression Enhances the Invasiveness of Human Prostate Cancer Cells by a Protein Kinase C{delta} Dependent Mechanism | Cancer Res. 2007 Nov 15;67(22):10859-68 | shRNA | TR320468 |
| PRKCE | Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281 | Cell. Signal. | shRNA | TR320469 |
| PRKCI | PRKCI negatively regulates autophagy via PIK3CA/AKT-MTOR signaling | Biochem. Biophys. Res. Commun. | shRNA | TR320472 |
| PRKCI | Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota | Cancer Res. 2008; 68(18): p. 7403-7408 | shRNA | TR320472 |
| PRKCQ | Suppression of protein kinase C theta contributes to enhanced myogenesis In vitro via IRS1 and ERK1/2 phosphorylation | BMC Cell Biol. 2013 Sep 21;14:39. | shRNA | TG501657 |
| PRKCZ | Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota | Cancer Res. 2008; 68(18): p. 7403-7408 | shRNA | TR320477 |
| PRKDC | DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes | PLoS ONE | shRNA | TR320478 |
| PRKN | Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance | Mol. Neurobiol. | shRNA | TG310609 |
| PRMT5 | Protein Arginine Methyltransferase 5 (PRMT5) Signaling Suppresses Protein Kinase C- and p38-dependent Signaling and Keratinocyte Differentiation | J. Biol. Chem., Mar 2012; 287: 7313 - 7323. | shRNA | TR310167 |
| PROM1 | Ultrasound-targeted microbubble destruction-mediated downregulation of CD133 inhibits epithelial-mesenchymal transition, stemness and migratory ability of liver cancer stem cells | Oncol. Rep. | shRNA | TG310163 |
| PRPF39 | Innate Sensing of Influenza A Virus Hemagglutinin Glycoproteins by the Host Endoplasmic Reticulum (ER) Stress Pathway Triggers a Potent Antiviral Response via ER-Associated Protein Degradation | Journal of Virology | shRNA | TL302262 |
| pRS | Exonuclease-1 interacts with the transcriptional co-repressor KAP1 | Matters | shRNA | TR20003 |
| PRS | Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection | J. Exp. Med., Aug 2011; 208: 1823 - 1834. | shRNA | |
| pRS | The Elk-1 and Serum Response Factor Binding Sites in the Major Immediate-Early Promoter of the Human Cytomegalovirus are Required for Efficient Viral Replication in Quiescent Cells and Compensate for Inactivation of the NF-{kappa}B Sites in Proliferating Cells | J. Virol., May 2010; 84: 4481 - 4493 | shRNA | |
| pRS vector | HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer | Nature (13 December 2009) doi:10.1038/nature08697 Letter | shRNA | |
| pRS vector | Heparanase Alters Arterial Structure, Mechanics, and Repair Following Endovascular Stenting in Mice | Circ. Res., Dec 2008; 10.1161/CIRCRESAHA.108.180695. | shRNA | |
| pRS vector | Tumor Suppressor Activity of CCAAT/Enhancer Binding Protein {alpha} Is Epigenetically Down-regulated in Head and Neck Squamous Cell Carcinoma | Cancer Res. 2007 May 15;67(10):4657-64. | shRNA | |
| PS100001 | Funktionelle Charakterisierung des putativen Tumorsuppressors Epithelial Membrane Protein 3 | Thesis | shRNA | TR30007 |
| PS100001 | CD109 plays a role in osteoclastogenesis | PLoS ONE Apr2013 | shRNA | TR30013 |
| PS100027 | Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch | Mol. Cell. Biol. | shRNA | TR30013 |
| PSIP1 | High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells | Cell. Physiol. Biochem. | shRNA | TR505629 |
| PSME3 | The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells | Nat Commun | shRNA | TG302223 |
| PSME3 | REGγ potentiates TGF-β/Smad signal dependent epithelial-mesenchymal transition in thyroid cancer cells | Cell. Signal. | shRNA | TG302223 |
| PSME3 | REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway | Cell Death Differ. | shRNA | TG302223 |
| PSME3 | REGγ deficiency suppresses tumor progression via stabilizing CK1ε in renal cell carcinoma | Cell Death Dis | shRNA | TG302223 |
| PSME3 | REGγ controls Hippo signaling and reciprocal NF-κB-YAP regulation to promote colon cancer | Clin. Cancer Res. | shRNA | TR501768 |
| PSME3 | REG? is critical for skin carcinogenesis by modulating the Wnt/ß-catenin pathway | Nat Commun | shRNA | TG302223 |
| PSME3 | PA28 is a novel corepressor of HTLV-1 replication and controls viral latency | Blood, Jan 2013; 121: 791 - 800. | shRNA | TG302223 |
| PSTPIP1 | PSTPIP1 inhibition of TCR signalling depends on its SH3 domain | FEBS J. July 2014 | shRNA | TF310088 |
| PTAFR | Feed forward reciprocal activation of PAFR and STAT3 regulates epithelial-mesenchymal transition in non-small cell lung cancer | Cancer Res. | shRNA | TR310087 |
| PTAFR | Platelet-activating factor receptor-mediated PI3K/AKT activation contributes to the malignant development of esophageal squamous cell carcinoma | Oncogene | shRNA | TR310087 |
| PTBP1 | Integrated analysis of a compendium of RNA-Seq datasets for splicing factors | bioRxiv | shRNA | TG501773 |
| PTEN | PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma | Scientific Reports | shRNA | TL320498 |
| PTEN | F-box and leucine-rich repeat protein 5 promotes colon cancer progression by modulating PTEN/PI3K/AKT signaling pathway | Biomed. Pharmacother. | shRNA | TG320498 |
| PTEN | Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a | Mol. Cancer | shRNA | TG320498 |
| PTEN | Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN | Cell Death Dis | shRNA | TG320498 |
| PTEN | Sensitivity of PTEN deficient non-small cell lung cancer to ionising radiation through inhibition of ataxia terangiectasia related 3 kinase (ATR) | Cancer Research | shRNA | TG320498 |
| PTEN | Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways | PLoS ONE | shRNA | TG320498 |
| PTEN | Signaling mechanisms coupled to CXCL12/CXCR4-mediated cellular proliferation are PTEN-dependent | Am J Clin Exp Urol | shRNA | TR320498 |
| PTEN | RIP1 Kinase Is an Oncogenic Driver in Melanoma | Cancer Res. | shRNA | TG320498 |
| PTEN | Atorvastatin overcomes gefitinib resistance in KRAS mutant human non-small cell lung carcinoma cells | Cell Death Dis. 2013 Sep 26;4:e814. doi: 10.1038/cddis.2013.312. | shRNA | TR320498 |
| PTEN | Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury | J Neurosci. 2013 Sep 25;33(39):15350-61 | shRNA | TR320498 |
| PTEN | Cooperation of protease-activated receptor 1 and integrin a?ß5 in thrombin-mediated lung cancer cell invasion | Oncol. Rep. | shRNA | TG320498 |
| PTEN | MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand | J. Biol. Chem., Jun 2010; 285: 20281 - 20290 | shRNA | TR320498 |
| PTEN | Immunosuppressive Cyclosporin A Activates AKT in Keratinocytes through PTEN Suppression: IMPLICATIONS IN SKIN CARCINOGENESIS | J. Biol. Chem., Apr 2010; 285: 11369 - 11377 | shRNA | TR320498 |
| PTGER2 | Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis | Cell. Microbiol. | shRNA | TG310080 |
| PTGER4 | Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis | Cell. Microbiol. | shRNA | TG310079 |
| PTGER4 | Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties | Breast Cancer Res. Treat. | shRNA | TR310079 |
| PTGES | Allergin-1 Immunoreceptor Suppresses House Dust Mite-Induced Allergic Airway Inflammation | J. Immunol. | shRNA | TG503457 |
| PTGES | Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1 | Nat Commun | shRNA | TG318942 |
| PTGR1 | Leukotriene B4 BLT Receptor Signaling Regulates the Level and Stability of Cyclooxygenase-2 (COX-2) mRNA through Restricted Activation of Ras/Raf/ERK/p42 AUF1 Pathway | J. Biol. Chem., Jul 2010; 285: 23568 - 23580. | shRNA | TR311650 |
| PTGS2 | Analysis of the in vitro and in vivo effects of Photodynamic Therapy on Prostate Cancer by using new photosensitizers, protoporphyrin IX-polyamine derivatives | Biochim. Biophys. Acta | shRNA | TR310074 |
| PTGS2 | Identification and validation of COX-2 as a co-target for overcoming cetuximab resistance in colorectal cancer cells | Oncotarget | shRNA | TG310074 |
| PTGS2 | IMP1 suppresses breast tumor growth and metastasis through the regulation of its target mRNAs | Oncotarget | shRNA | TG310074 |
| PTGS2 | Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections | Nat. Med. | shRNA | TG310074 |
| PTGS2 | Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis | Cell. Microbiol. | shRNA | TG501784 |
| PTGS2 | Premetastatic soil and prevention of breast cancer brain metastasis | Neuro Oncology, Jul 2013; 15: 891 - 903. | shRNA | TG310074 |
| PTK2 | Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis | Cell Rep | shRNA | TG514293 |
| Ptk2b | α 1 -Adrenergic receptor–PKC–Pyk2–Src signaling boosts L-type Ca 2+ channel Ca V 1.2 activity and long-term potentiation in rodents | eLife | shRNA | TL710108 |
| PTK2B | The Human Ion Channel TRPM2 Modulates Neuroblastoma Cell Survival and Mitochondrial Function through Pyk2, CREB, and MCU Activation | Am. J. Physiol., Cell Physiol. | shRNA | TG320352 |
| Ptk2b | Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK | J. Neurosci. | shRNA | TR501788 |
| PTK7 | Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis | J. Biol. Chem. July 2014 | shRNA | TF200451 |
| PTP4A3 | PRL-3 activates mTORC1 in Cancer Progression | Sci Rep | shRNA | TR320652 |
| Ptpn12 | Macrophage Fusion Is Controlled by the Cytoplasmic Protein Tyrosine Phosphatase PTP-PEST/PTPN12 | Mol. Cell. Biol., Jun 2013; 33: 2458 - 2469. | shRNA | TG310066 |
| Ptpn13 | The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. | Oncogene | shRNA | TL510136 |
| PTPN21 | BMX negatively regulates BAK function thereby increasing apoptotic resistance to chemotherapeutic drugs | Cancer Res. | shRNA | TR310062 |
| PTPN5 | Tyrosine dephosphorylation is required for Bak activation in apoptosis | The EMBO Journal (19 October 2010) doi:10.1038/emboj.2010.244 Article | shRNA | TR310058 |
| PTPN6 | SC-2001 Overcomes STAT3-mediated Sorafenib Resistance through RFX-1/SHP-1 Activation in Hepatocellular Carcinoma | Neoplasia July 2014 | shRNA | TG310057 |
| PTPRH | Tyrosine dephosphorylation is required for Bak activation in apoptosis | The EMBO Journal | shRNA | TR310053 |
| PTPRJ | Tumor Suppressor Density-enhanced Phosphatase-1 (DEP-1) Inhibits the RAS Pathway by Direct Dephosphorylation of ERK1/2 Kinases | J. Biol. Chem., Aug 2009; 284: 22048 - 22058 | shRNA | TR310052 |
| PTRH2 | Downregulation of Bit1 expression promotes growth, anoikis resistance, and transformation of immortalized human bronchial epithelial cells via Erk activation-dependent suppression of E-cadherin | Biochem. Biophys. Res. Commun.2017 | shRNA | TR302190 |
| PTRH2 | The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells | PLoS ONE | shRNA | TR302190 |
| PTTG1 | Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13 | Tumour Biol. | shRNA | TG310042 |
| PTTG1 | PTTG1 Oncogene Promotes Tumor Malignancy via Epithelial to Mesenchymal Transition and Expansion of Cancer Stem Cell Population | J. Biol. Chem., Jun 2012; 287: 19516 - 19527. | shRNA | TR310042 |
| PUM2 | Translational Regulation of Acetylcholinesterase by the RNA-binding Protein Pumilio-2 at the Neuromuscular Synapse | J. Biol. Chem., Oct 2011; 286: 36492 - 36499. | shRNA | TR302189 |
| PWP1 | PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin | Onco Targets Ther | shRNA | TR310031 |
| PYCARD | Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing | Biochim. Biophys. Acta, Feb 2014. | shRNA | TR310027 |
| Pygo2 | Overexpression of Pygopus-2 is required for canonical Wnt activation in human lung cancer | Oncol Lett, Dec 2013. | shRNA | TF317702 |
| QPRT | The Endogenous Tryptophan Metabolite and NAD+ Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress | Cancer Res., Jun 2013; 73: 3225 - 3234. | shRNA | TG310018 |
| QSOX1 | Quiescin Sulfhydryl Oxidase 1 (QSOX1) Secreted by Lung Cancer Cells Promotes Cancer Metastasis | Int J Mol Sci | shRNA | TG310017 |
| QSOX1 | Quiescin Sulfhydryl Oxidase 1 (QSOX1) Secreted by Lung Cancer Cells Promotes Cancer Metastasis | Preprints | shRNA | TG515942 |
| RAB10 | Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience | Genome Med | shRNA | TG302162 |
| RAB11A | Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction | Sci Signal | shRNA | TR711274 |
| RAB11A | Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction | Am. J. Physiol., Cell Physiol. | shRNA | TG310015 |
| Rab31 | INVESTIGATIONS ON RAB31'S ROLE IN EGFR TRAFFICKING AND NEURAL PROGENITOR CELL DIFFERENTIATION TOWARDS ASTROGLIA | Thesis | shRNA | TF509046 |
| Rab31 | Engagement of the Small GTPase Rab31 and its Effector, Early Endosome Antigen 1, is Important for Trafficking of Ligand-bound Epidermal Growth Factor Receptor from Early to Late Endosome | J. Biol. Chem. | shRNA | TF509046 |
| RAB4A | Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction | Am. J. Physiol., Cell Physiol. | shRNA | TG309988 |
| RAB7A | Rab7 Regulates CDH1 Endocytosis, Circular Dorsal Ruffles Genesis and Thyroglobulin Internalization in a Thyroid Cell Line | J. Cell. Physiol. | shRNA | TR710925 |
| RAB7A | Bovine Ephemeral Fever Virus Uses a Clathrin-Mediated and Dynamin 2-Dependent Endocytosis Pathway That Requires Rab5 and Rab7 as Well as Microtubules | J. Virol., Dec 2012; 86: 13653 - 13661. | shRNA | TG309983 |
| RAB7A | Large Putative PEST-like Sequence Motif at the Carboxyl Tail of Human Calcium Receptor Directs Lysosomal Degradation and Regulates Cell Surface Receptor Level | J. Biol. Chem., Feb 2012; 287: 4165 - 4176. | shRNA | TR309983 |
| RAB8B | Tuba activates Cdc42 during neuronal polarization downstream of the small GTPase Rab8a | bioRxiv | shRNA | TG713207 |
| Rac1 | CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility | eLife | shRNA | TL712781 |
| RAC2 | Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors | Blood, May 2012; 119: 4253 - 4263. | shRNA | TR318935 |
| RAC3 | Role of RAC3 coactivator in the adipocyte differentiation | Cell Death Discov | shRNA | TG510528 |
| RACK1 | NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4 | Am. J. Physiol. Heart Circ. Physiol. | shRNA | TR312717 |
| RAD17 | ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress | Cell July 2014 | shRNA | TR302133 |
| RAD54L | BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54 | J. Cell Sci., Aug 2009; 10.1242/jcs.051813 | shRNA | TR309964 |
| RAD9A | Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery | Hum. Mol. Genet., Oct 2010; 10.1093/hmg/ddq451 | shRNA | TR309962 |
| Raf1 | Crosstalk between autophagy and apoptosis in the regulation of paclitaxel-induced cell death in v-Ha-ras-transformed fibroblasts. | Molecular and cellular biochemistry | shRNA | TR516793 |
| RALA | Nodal signals via ß-arrestins and RalGTPases to regulate trophoblast invasion | Cell. Signal. | shRNA | TR309957 |
| RALa | Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK | Cellular Signalling, Volume 21, Issue 7, July 2009, Pages 1207-1217 | shRNA | TR309957 |
| RALa | ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells | Mol. Cancer Res., Jul 2009; 7: 1064 - 1077 | shRNA | TR309957 |
| RALB | Nodal signals via ß-arrestins and RalGTPases to regulate trophoblast invasion | Cell. Signal. | shRNA | TR309956 |
| RALb | Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK | Cellular Signalling, Volume 21, Issue 7, July 2009, Pages 1207-1217 | shRNA | TR309956 |
| RALb | ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells | Mol. Cancer Res., Jul 2009; 7: 1064 - 1077 | shRNA | TR309956 |
| RAMP1 | Calcitonin Gene-Related Peptide Rescues Proximity Associations of Its Receptor Components Calcitonin Receptor-Like-Receptor and Receptor Activity Modifying Protein1 in Rat Uterine Artery Smooth Muscle Cells Exposed to Tumor Necrosis Factor-Alpha | Biol. Reprod. | shRNA | TR711449 |
| RANBP2 | Cdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells | Dev. Cell | shRNA | TG309949 |
| Rap1gds1 | Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis. | Stem cell research | shRNA | TL506858 |
| Rap1gds1 | Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis | Stem Cell Res2017 | shRNA | TG506858 |
| RAPGEF3 | Pancreatic ß-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A | Diabetes, Aug 2013; 62: 2796 - 2807. | shRNA | TR512817 |
| RASGRF1 | Running title: RasGRF and cocaine | pdfs.semanticscholar.org | shRNA | TR302103 |
| RASGRF2 | Running title: RasGRF and cocaine | pdfs.semanticscholar.org | shRNA | TR309928 |
| RASSF1 | The RASSF1A Tumor Suppressor Binds the RasGAP DAB2IP and Modulates RAS Activation in Lung Cancer | Cancers | shRNA | TG307696 |
| RASSF1 | The RASSF1A Tumor Suppressor Regulates XPA-Mediated DNA repair | Mol. Cell. Biol. | shRNA | TR307696 |
| RASSF10 | RASSF10 is Epigenetically Inactivated and Suppresses Cell Proliferation and Induces Cell Apoptosis by Activating the p53 Signalling Pathway in Papillary Thyroid Carcinoma Cancer | Cell. Physiol. Biochem | shRNA | TR320923 |
| RASSF10 | Ras association domain family member 10 suppresses gastric cancer growth by cooperating with GSTP1 to regulate JNK/c-Jun/AP-1 pathway | Oncogene | shRNA | TG320923 |
| RASSF5 | NORE1A Tumor Suppressor Candidate Modulates p21CIP1 via p53 | Cancer Res., Jun 2009; 69: 4629 - 4637. | shRNA | TR302093 |
| Rbfox3 | Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development | J. Cell Biol., Feb 2013; 200: 443 - 458. | shRNA | TR502927 |
| RBL1 | p107-Dependent recruitment of SWI/SNF to the alkaline phosphatase promoter during osteoblast differentiation | Bone | shRNA | TF509105 |
| RBM25 | A novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection | Mol. Cell. Biol. published 28 July 2008, 10.1128/MCB.00560-08 | shRNA | TR302072 |
| RBM5 | Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer | Tumour Biol | shRNA | TR309910 |
| RBPJ | Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity | Stem Cell Reports | shRNA | MR226108 |
| Rbpj | Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells | Elife | shRNA | TG512813 |
| RBPJ | Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a ?-secretase inhibitor, in a preclinical colorectal explant model | British Journal of Cancer doi:10.1038/bjc.2013.361 | shRNA | TF302060 |
| RCAN1 | Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4 | Cancer Lett. | shRNA | TR304903 |
| Rcan1 | Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction | Biochem. Pharmacol. | shRNA | TR511392 |
| RCAN1 | RCAN1-4 is a thyroid cancer growth and metastasis suppressor | JCI Insight | shRNA | TR304903 |
| RCAN1 | Pituitary adenylate cyclase-activating polypeptide (PACAP) targets Down syndrome candidate region 1 (DSCR1/RCAN1) to control neuronal differentiation | J. Biol. Chem. | shRNA | TG713231 |
| RCAN1 | APP facilitates the RCAN1-mediated apoptosis by downregulating PSMA5 and PSMB7 | Neurobiology of Aging | shRNA | TF304903 |
| RCAN1 | The Regulator of Calcineurin 1 (RCAN1/DSCR1) Activates the cAMP Response Element-binding Protein (CREB) Pathway | J. Biol. Chem., Oct 2011; 286: 37841 - 37848. | shRNA | TR511392 |
| REC8 | REC8 inhibits EMT by downregulating EGR1 in gastric cancer cells | Oncol. Rep. | shRNA | TG309883 |
| REC8 | REC8 functions as a tumor suppressor and is epigenetically downregulated in gastric cancer, especially in EBV-positive subtype | Oncogene | shRNA | TG309883 |
| Rec8 | The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells. | Experimental cell research | shRNA | TL509475 |
| RECQL4 | Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis | Cancer Res., Nov 2010; 70: 9207 - 9217 | shRNA | TR309882 |
| REG1A | REG{gamma} deficiency promotes premature aging via the casein kinase 1 pathway | PNAS, Jul 2013; 110: 11005 - 11010. | shRNA | TG309878 |
| REG4 | REG{gamma} modulates p53 activity by regulating its cellular localization | J. Cell Sci., Dec 2010; 123: 4076 - 4084 | shRNA | TR302039 |
| RELA | Time-lapse imaging of p65 and IκBα translocation kinetics following Ca2+-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons | Molecular and Cellular Neuroscience | shRNA | TG713753 |
| RELA | NF-?B regulates neuronal ankyrin-G via a negative feedback loop | Sci Rep | shRNA | TR516660 |
| RELA | COMMD7 is correlated with a novel NF-?B positive feedback loop in hepatocellular carcinoma | Oncotarget | shRNA | TR302038 |
| RELA | Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a γ -secretase inhibitor, in a preclinical colorectal explant model | British Journal of Cancer | shRNA | TF302038 |
| RELA | Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF-{kappa}B Signaling Pathway | Mol. Cancer Ther., Jan 2011; 10: 198 - 208 | shRNA | TR302038 |
| RELA | Angiotensin II-regulated transcription regulatory genes in adrenal steroidogenesis | Physiol Genomics, Nov 2010; 42A: 259 - 266 | shRNA | TR302038 |
| RFC1 | Phosphoinositide 3-kinase beta controls replication factor C assembly and function | Nucleic Acids Res., Jan 2013; 41: 855 - 868. | shRNA | TG501877 |
| RFC2 | DNA damage response defect in Williams-Beuren syndrome | Int. J. Mol. Med. | shRNA | TG309864 |
| RFC2 | PLA2G16 represents a switch between entry and clearance of Picornaviridae | Nature | shRNA | TG309864 |
| RFC2 | DNA damage response defect in Williams‑Beuren syndrome | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | shRNA | TG309864 |
| RFC4 | Phosphoinositide 3-kinase beta controls replication factor C assembly and function | Nucleic Acids Res., Jan 2013; 41: 855 - 868. | shRNA | TG505746 |
| RFX1 | RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells | Carcinogenesis | shRNA | TG309857 |
| RFX1 | SC-2001 Overcomes STAT3-mediated Sorafenib Resistance through RFX-1/SHP-1 Activation in Hepatocellular Carcinoma | Neoplasia July 2014 | shRNA | TR309857 |
| RGCC | Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells | Am J Physiol Cell Physiol, Jun 2011; 300: C1415 - C1421 | shRNA | TR315657 |
| RGS4 | Decreased levels of RGS4 in the paraventricular nucleus facilitate GABAergic inhibition during the acute stress response | Biochem. Biophys. Res. Commun. | shRNA | TG510988 |
| RGS4 | Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4 | Cancer Res., Jul 2009; 69: 5743 - 5751. | shRNA | TR309833 |
| RHBDD1 | Intramembrane protease RHBDL4 interacts with erlin complex to target unstable soluble proteins for degradation | bioRxiv | shRNA | TR302010 |
| RHBDF1 | Human rhomboid family-1 modulates clathrin coated vesicle-dependent pro-transforming growth factor α membrane trafficking to promote breast cancer progression | EBioMedicine | shRNA | TR302009 |
| RHBDF1 | Human Rhomboid Family-1 (RHBDF1) Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1a in Breast Cancer | Cancer Res. | shRNA | TF302009 |
| RHOA | Cooperation of G12/13 and Gi proteins via lysophosphatidic acid receptor-2 (LPA2) signaling enhances cancer cell survival to cisplatin | Biochemical and Biophysical Research Communications | shRNA | TG309823 |
| RHOA | S100A4 is activated by RhoA and catalyzes the polymerization of non-muscle myosin, adhesion complex assembly and contraction in airway smooth muscle | J. Physiol. (Lond.) 2020 | shRNA | TG309823 |
| RHOC | Cooperation of G12/13 and Gi proteins via lysophosphatidic acid receptor-2 (LPA2) signaling enhances cancer cell survival to cisplatin | Biochemical and Biophysical Research Communications | shRNA | TG302002 |
| RHOQ | GTP Hydrolysis of TC10 Promotes Neurite Outgrowth through Exocytic Fusion of Rab11- and L1-Containing Vesicles by Releasing Exocyst Component Exo70 | PLoS ONE e79689 | shRNA | TF309817 |
| RHOT1 | Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy | EMBO J., Feb 2014. | shRNA | TG309816 |
| RHOU | The Transforming Rho Family GTPase Wrch-1 Disrupts Epithelial Cell Tight Junctions and Epithelial Morphogenesis | Mol. Cell. Biol., Feb 2009; 29: 1035 - 1049. | shRNA | TR307205 |
| RICTOR | Potential Role of mTORC2 as a Therapeutic Target in Clear Cell Carcinoma of the Ovary | Mol. Cancer Ther., Jul 2013; 12: 1367 - 1377. | shRNA | TG307650 |
| Rif1 | A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. | Molecular cell | shRNA | TF502862 |
| RIOX2 | Paradoxical roles of mineral dust induced gene on cell proliferation and migration/invasion | PLoS ONE, Feb 2014. | shRNA | TF317654 |
| RIPK1 | RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy | Autophagy | shRNA | TG320591 |
| RIPK1 | RIP1 Kinase Is an Oncogenic Driver in Melanoma | Cancer Res. | shRNA | TG320591 |
| RMDN3 | Effectiveness of EGFR/HER2-targeted drugs is influenced by the downstream interaction shifts of PTPIP51 in HER2-amplified breast cancer cells | Oncogenesis | shRNA | TG304606 |
| RNASEK | A Subtle Alternative Splicing Event Gives Rise to a Widely Expressed Human RNase k Isoform | PLoS ONE | shRNA | TR318608 |
| RNF8 | Identification of RNF8 as a Ubiquitin Ligase Involved in Targeting the p12 Subunit of DNA Polymerase for Degradation in Response to DNA Damage | J. Biol. Chem., Feb 2013; 288: 2941 - 2950. | shRNA | TG309783 |
| RNH1 | Genomic Analysis of Chemo-Resistance to HDAC inhibitor in Gastric Cancer cells | Thesis Jul 2014 | shRNA | TG309781 |
| RNH1 | RNH1 regulation of reactive oxygen species contributes to histone deacetylase inhibitor resistance in gastric cancer cells | Oncogene doi:10.1038/onc.2013.104 | shRNA | TG309781 |
| ROCK1 | Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways | PLoS ONE | shRNA | TG309775 |
| ROR2 | Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma | Oncogene (18 May 2009) doi:10.1038/onc.2009.116 Original Article | shRNA | TR320439 |
| RORA | Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting Beta-catenin and AKT signaling but frequently methylated in common carcinomas | Cell Mol Life Sci. 2013 Oct 25 | shRNA | TR320515 |
| RPA1 | ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress | Cell July 2014 | shRNA | TR309767 |
| RPS6KA1 | Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway | Oncotarget | shRNA | TR320517 |
| RPS6KA3 | Phosphorylation of RSK2 at Tyr529 by FGFR2-p38 enhances human mammary epithelial cells migration | Biochim. Biophys. Acta July 2014 | shRNA | TG320519 |
| Rps6ka4 | miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy | Nat Commun | shRNA | TR503222 |
| Rps6ka5 | Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes | Epigenetics Chromatin | shRNA | TR504795 |
| RPS6KB1 | Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade | Cell death and differentiation | shRNA | TF320520 |
| Rps6kb1 | S6K directly phosphorylates IRS-1 on Ser270 to promote insulin resistance in response to TNF-alpha signaling through IKK2 | J. Biol. Chem. published 24 October 2008, 10.1074/jbc.M806480200 | shRNA | TR504743 |
| RSU1 | Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis | PLoS One. 2013 Sep 18;8(9):e74625 | shRNA | RG203334 |
| Runx1 | Neural EGFL like 1 as a potential pro-chondrogenic, anti-inflammatory dual-functional disease-modifying osteoarthritis drug | Biomaterials | shRNA | TL500282 |
| RUNX1 | MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5 | Cell. Signal. | shRNA | TG309685 |
| Runx2 | Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths | Cell reports | shRNA | TF510502 |
| Runx2 | Neural EGFL-Like 1 Regulates Cartilage Maturation through Runt-Related Transcription Factor 3–Mediated Indian Hedgehog Signaling | The American Journal of Pathology | shRNA | TF510502 |
| Runx2 | Nfatc1 Is a Functional Transcriptional Factor Mediating Nell-1-Induced Runx3 Upregulation in Chondrocytes | International Journal of Molecular Sciences | shRNA | TF510502 |
| RUNX2 | RUNX2 in subtype specific breast cancer and mammary gland differentiation | Dis Model Mech | shRNA | TG309683 |
| RUNX3 | IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression. | JCI insight | shRNA | TL309682 |
| RUNX3 | The cell-surface 5′-nucleotidase CD73 defines a functional T memory cell subset that declines with age | Cell reports | shRNA | TL309682 |
| Runx3 | Neural EGFL-Like 1 Regulates Cartilage Maturation through Runt-Related Transcription Factor 3–Mediated Indian Hedgehog Signaling | The American Journal of Pathology | shRNA | TG500285 |
| Rxra | Retinoid-X-Receptors (a/ß) in Melanocytes Modulate Innate Immune Responses and Differentially Regulate Cell Survival following UV Irradiation | PLoS Genet. | shRNA | TG501955 |
| Rxrb | Retinoid-X-Receptors (a/ß) in Melanocytes Modulate Innate Immune Responses and Differentially Regulate Cell Survival following UV Irradiation | PLoS Genet. | shRNA | TF501956 |
| S100A4 | S100A4 is activated by RhoA and catalyzes the polymerization of non-muscle myosin, adhesion complex assembly and contraction in airway smooth muscle | J. Physiol. (Lond.) 2020 | shRNA | TG309668 |
| S100a8 | Hypoxia-Induced S100A8 Expression Activates Microglial Inflammation and Promotes Neuronal Apoptosis | International Journal of Molecular Sciences | shRNA | TL712179 |
| S100B | S100B Promotes Glioma Growth through Chemoattraction of Myeloid-Derived Macrophages | Clin. Cancer Res., Jul 2013; 19: 3764 - 3775. | shRNA | TG309665 |
| S1PR1 | Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways | Blood, Aug 2008; 112: 1129 - 1138. | shRNA | TR313301 |
| S1PR3 | Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways | Blood, Jun 2008; 10.1182/blood-2007-11-125203. | shRNA | TR313299 |
| SAR1A | Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience | Genome Med | shRNA | TG301838 |
| SATB1 | SATB1 Knockdown Inhibits Proliferation and Invasion and Decreases Chemoradiation Resistance in Nasopharyngeal Carcinoma Cells by Reversing EMT and Suppressing MMP-9 | Int J Med Sci. | shRNA | TG309643 |
| SATB1 | Silencing SATB1 influences cell invasion, migration, proliferation, and drug resistance in nasopharyngeal carcinoma | Int J Clin Exp Pathol | shRNA | TG309643 |
| SATB2 | Role of miR-31 and SATB2 in arsenic-induced malignant BEAS-2B cell transformation | Mol. Carcinog. | shRNA | TG301833 |
| SATB2 | Molecular Mechanisms of Malignant Transformation by Low Dose Cadmium in Normal Human Bronchial Epithelial Cells | PLoS ONE | shRNA | TG301833 |
| SATB2 | SATB2 expression increased anchorage-independent growth and cell migration in human bronchial epithelial cells | Toxicol. Appl. Pharmacol. | shRNA | TG301833 |
| SAV1 | Salvador Protein Is a Tumor Suppressor Effector of RASSF1A with Hippo Pathway-independent Functions | J. Biol. Chem., May 2011; 286: 18483 - 18491 | shRNA | TR301832 |
| SCARB1 | Chlamydia trachomatis utilizes the mammalian CLA1 lipid transporter to acquire host phosphatidylcholine essential for growth | Cell. Microbiol. | shRNA | TG309633 |
| SCG3 | Carboxypeptidase E and Secretogranin III coordinately facilitate efficient sorting of pro-opiomelanocortin to the regulated secretory pathway in AtT20 cells | Molecular Endocrinology Dec2015 | shRNA | TR516044 |
| SCIMP | SCIMP, a Transmembrane Adaptor Protein Involved in Major Histocompatibility Complex Class II Signaling | Mol. Cell. Biol., Nov 2011; 31: 4550 - 4562. | shRNA | |
| SCPEP1 | Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1 | PLoS Genet. | shRNA | TF505007 |
| Scrambled Control | Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules | Redox biology | shRNA | TR30013 |
| Scrambled Control | Targeting SIRT2 Sensitizes Melanoma Cells to Cisplatin via an EGFR-Dependent Mechanism | International Journal of Molecular Sciences | shRNA | TR30012 |
| Scrambled Control | NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) modulation by intracellular Cl- concentration | Immunology | shRNA | TR30013 |
| Scrambled Control | Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein | Viruses | shRNA | TR30013 |
| Scrambled Control | Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression | Scientific reports | shRNA | TR30012 |
| Scrambled Control | Extrinsic Regulators of mRNA Translation in Developing Brain: Story of WNTs | Cells | shRNA | TR30013 |
| Scrambled Control | Cell dynamics in Hertwig\'s epithelial root sheath are regulated by β-catenin activity during tooth root development | Journal of cellular physiology | shRNA | TR30013 |
| Scrambled Control | Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells | J Cell Physiol | shRNA | TR30013 |
| Scrambled Control | USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway | Proc Natl Acad Sci U S A | shRNA | TR30015 |
| Scrambled Control | Matrin-3 plays an important role in cell cycle and apoptosis for survival in malignant melanoma | J. Dermatol. Sci. | shRNA | TR30021 |
| Scrambled Control | TGFβ-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Maintenance | SSRN Journal | shRNA | TR30015 |
| Scrambled Control | Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction | Nat Commun | shRNA | TR30015 |
| Scrambled Control | Imbalance of a KLF4-miR-7 auto-regulatory feedback loop promotes prostate cancer cell growth by impairing microRNA processing | Am J Cancer Res | shRNA | TR30013 |
| Scrambled Control | Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience | Genome Med | shRNA | TR30013 |
| Scrambled shRNA | Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology | Nat Commun | shRNA | TR30012 |
| Scrambled shRNA | Calcium release mediated by redox-sensitive RyR2 channels has a central role in hippocampal structural plasticity and spatial memory | Antioxid. Redox Signal. | shRNA | TR30013 |
| scrambled shRNA | Calcium release mediated by redox-sensitive RyR2 channels has a central role in hippocampal structural plasticity and spatial memory | Antioxid. Redox Signal. | shRNA | TR30015 |
| SCRT2 | Scratch2 Modulates Neurogenesis and Cell Migration Through Antagonism of bHLH Proteins in the Developing Neocortex | Cereb Cortex, Nov 2012; 10.1093/cercor/bhs356. | shRNA | TG307416 |
| SDC2 | Binding of Y-P30 to Syndecan 2/3 Regulates the Nuclear Localization of CASK | PLoS ONE, Feb 2014. | shRNA | TR309597 |
| SDC3 | Binding of Y-P30 to Syndecan 2/3 Regulates the Nuclear Localization of CASK | PLoS ONE, Feb 2014. | shRNA | TR309596 |
| SDC4 | Myoblast Migration and Directional Persistence Affected by Syndecan-4-Mediated Tiam-1 Expression and Distribution | Int J Mol Sci | shRNA | TR513122 |
| SDC4 | Syndecan-4 influences mammalian myoblast proliferation by modulating myostatin signalling and G1/S transition | FEBS Lett. | shRNA | TR513122 |
| Sdcbp | Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells | Frontiers in Pharmacology | shRNA | TG512166 |
| SDHA | Complex I and II are required for normal mitochondrial Ca2+ homeostasis | Mitochondrion | shRNA | TR315539 |
| SELENOP | Selenoprotein P neutralizes lipopolysaccharide and participates in hepatic cell endoplasmic reticulum stress response | FEBS Lett | shRNA | TR309547 |
| SEMA6D | The Plexin-A1 Receptor Activates Vascular Endothelial Growth Factor-Receptor 2 and Nuclear Factor-B to Mediate Survival and Anchorage-Independent Growth of Malignant Mesothelioma Cells | Cancer Res., Feb 2009; 69: 1485 - 1493 | shRNA | TR301776 |
| SENP3 | Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity | J Toxicol Sci | shRNA | TG505363 |
| SENP3 | Protective effect of SENP3-mediated SUMOylation against cadmium toxicity | J Toxicol Sci | shRNA | TG701864 |
| Senp5 | Synaptic localization of the SUMOylation-regulating protease SENP5 in the adult mouse brain. | The Journal of comparative neurology | shRNA | TL508307 |
| SENP7 | Novel SUMO-Protease SENP7S Regulates ß-catenin Signaling and Mammary Epithelial Cell Transformation | Sci Rep | shRNA | TR301771 |
| Septin2 | Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion | J. Cell Biol. | shRNA | TG515794 |
| Septin5 | Mapping axon initial segment structure and function by multiplexed proximity biotinylation | Nature Communications | shRNA | TL501695 |
| Septin6 | Mapping axon initial segment structure and function by multiplexed proximity biotinylation | Nature Communications | shRNA | TL509453 |
| Serpina1 | Endothelial-mesenchymal transition in atherosclerotic lesion calcification | Atherosclerosis | shRNA | TR710718 |
| Serpinb2 | Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren’s syndrome | Cell Death & Disease | shRNA | TL710486 |
| SERPINB2 | PNAS Plus: TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2 | PNAS, Jan 2012; 109: E177 - E186. | shRNA | TR309533 |
| SERPINB9 | Anti-Apoptotic Gene Delivery with cyclo-(d-Trp-Tyr) Peptide Nanotube via Eye Drop Following Corneal Epithelial Debridement | Pharmaceutics | shRNA | TF309527 |
| SERPINE1 | Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease | Aging Cell | shRNA | TF709263 |
| SESN2 | HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells | Cell Death Dis | shRNA | TG301755 |
| SETD7 | SET9-Mediated Regulation of TGF-ß Signaling Links Protein Methylation to Pulmonary Fibrosis | Cell Rep | shRNA | TG301748 |
| SETMAR | Metnase mediates chromosome decatenation in acute leukemia cells | Blood, May 2009; 10.1182/blood-2008-08-175760 | shRNA | TR309513 |
| Sf1 | DNA damage causes rapid accumulation of phosphoinositides for ATR signaling | Nat Commun | shRNA | TF516038 |
| SFRP5 | Secreted frizzled-related protein 5 protects against oxidative stress-induced apoptosis in human aortic endothelial cells via downregulation of Bax | J. Biochem. Mol. Toxicol. | shRNA | TR309497 |
| SFXN4 | Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer | Scientific Reports | shRNA | TL301736 |
| SGK1 | p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis | Aging (Albany NY) 2019 | shRNA | TG502013 |
| Sgms1 | The suppression of ghrelin signaling mitigates age-associated thermogenic impairment | Aging (Albany NY) | shRNA | TG506246 |
| SGTA | Tumor suppressor REIC/Dkk‑3 and its interacting protein SGTA inhibit glucocorticoid receptor to nuclear transport | Exp Ther Med | shRNA | TG309472 |
| sh-Luc(in vivo application) | RNA interference-mediated in vivo silencing of FasL as a strategy for the enhancement of DNA vaccine potency | Human Gene Therapy. August 2008, 19(8): 763-773 | shRNA | |
| SH3BGRL | SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane | J. Exp. Clin. Cancer Res. | shRNA | TG309466 |
| SH3BGRL | SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia | Leuk. Lymphoma | shRNA | TG309466 |
| SH3GL2 | SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane | Journal of Experimental & Clinical Cancer Research : CR | shRNA | TG309461 |
| SH3GL2 | SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia. | Leukemia & lymphoma | shRNA | TG309461 |
| SH3GL2 | Dual-faced SH3BGRL: oncogenic in mice, tumor suppressive in humans | Oncogene | shRNA | TG309461 |
| shank3 | SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism | Molecular Psychiatry (24 May 2011) doi:10.1038/mp.2011.57 Original Article | shRNA | TR320871 |
| shRNA | Human ß-defensin-2 enhances IFN-{gamma} and IL-10 production and suppresses IL-17 production in T cells | J. Leukoc. Biol., Jun 2011; 89: 935 - 944 | shRNA | |
| shRNA | GPR103b Functions in the Peripheral Regulation of Adipogenesis | Mol. Endocrinol., Aug 2010; 24: 1615 - 1625 | shRNA | |
| shRNA | A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR Signaling | J. Immunol., Apr 2010; 184: 3689 - 3696 | shRNA | |
| shRNA | TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-B | J. Leukoc. Biol., Mar 2008; 83: 702 - 707 | shRNA | |
| SIGLECE | Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production | J. Immunol., Dec 2009; 183: 7703 - 7709 | shRNA | TR512042 |
| SIGMAR1 | SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism | J. Pharmacol. Sci. | shRNA | TG311012 |
| SIGMAR1 | Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP 3 -Evoked Ca 2+ Signals through Sigma-1 Receptors | Cell Reports | shRNA | TF311012 |
| Sigmar1 | Cocaine Inhibits Store-Operated Ca 2+ Entry in Brain Microvascular Endothelial Cells: Critical Role for Sigma-1 Receptors | The Biochemical journal | shRNA | TF711128 |
| SIGMAR1 | Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances | Cell Death Dis | shRNA | TF311012 |
| SIGMAR1 | Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis | Hum. Mol. Genet., Apr 2013; 22: 1581 - 1600. | shRNA | TG311012 |
| SIRT1 | Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a | Mol. Cancer | shRNA | TG309433 |
| SIRT1 | Chronic sun exposure is associated with distinct histone acetylation changes in human skin | Br. J. Dermatol.2017 | shRNA | TG309433 |
| SIRT1 | SIRT1 promotes metastasis of human osteosarcoma cells | Oncotarget | shRNA | TG309433 |
| SIRT2 | Targeting SIRT2 Sensitizes Melanoma Cells to Cisplatin via an EGFR-Dependent Mechanism | International Journal of Molecular Sciences | shRNA | TR301692 |
| SIRT2 | SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor Dasatinib | Cancers (Basel) 2019 | shRNA | TR301692 |
| SIRT2 | Sirt2 Regulates Radiation-Induced Injury | Radiat. Res. | shRNA | TG301692 |
| Sirt2 | SIRT2 Interacts with β-catenin to Inhibit Wnt Signaling Output in Response to Radiation-Induced Stress | Molecular cancer research : MCR | shRNA | TL503462 |
| SIRT3 | GATA3 ameliorates melanocyte injuries in vitiligo through SIRT3-mediated HMGB1 deacetylation. | The Journal of dermatology | shRNA | TG309432 |
| SIRT3 | Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells | Oncogene | shRNA | TR309432 |
| SIRT3 | Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer. | Journal of cellular physiology | shRNA | TR309432 |
| SIRT3 | Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells | bioRxiv | shRNA | TR309432 |
| SIRT3 | Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells | Am. J. Physiol., Cell Physiol. | shRNA | TR309432 |
| SIRT7 | SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair | EMBO J. | shRNA | TR301690 |
| SIX1 | HPV16-transformed human keratinocytes depend on SIX1 expression for proliferation and HPV E6/E7 gene expression | Virology | shRNA | TG309429 |
| SKP2 | Down-regulation of Skp2 expression inhibits invasion and lung metastasis in osteosarcoma | Sci Rep | shRNA | TG301684 |
| SLAMF1 | SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response | J. Clin. Invest. | shRNA | TG309422 |
| SLC16A1 | Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. | Cell reports | shRNA | TL309405 |
| SLC16A1 | Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer | Cell Rep | shRNA | TR309405 |
| SLC17A5 | From the Cover: Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane | PNAS, Aug 2012; 109: 13434 - 13439. | shRNA | TR309394 |
| SLC17A5 | Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane | PNAS, Jul 2012; 10.1073/pnas.1116633109. | shRNA | TR309394 |
| SLC1A3 | Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I | Diabetes | shRNA | TR515328 |
| SLC22A18 | Knockdown of Orphan Transporter SLC22A18 Impairs Lipid Metabolism and Increases Invasiveness of HepG2 Cells | Pharm. Res. | shRNA | TR309377 |
| SLC22A18 | Involvement of an orphan transporter, SLC22A18, in cell growth and drug resistance of human breast cancer MCF7 cells | J Pharm Sci | shRNA | TR309377 |
| Slc22a2 | The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus | eLife | shRNA | TL517269 |
| SLC25A1 | SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker | Oncotarget | shRNA | TG316728 |
| SLC25A1 | The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis | Oncotarget | shRNA | TG316728 |
| SLC26A9 | Effects of Wood Smoke Constituents on Mucin Gene Expression in Mice and Human Airway Epithelial Cells and on Nasal Epithelia of Subjects with a Susceptibility Gene Variant in Tp53 | Environmental Health Perspectives | shRNA | TR301620 |
| SLC29A1 | SLC29A1 (ENT1) polymorphisms and outcome of complete remission in acute myeloid leukemia | Cancer Chemother. Pharmacol. | shRNA | TG309346 |
| SLC2A4 | GLUT4 Mobilization Supports Energetic Demands of Active Synapses | Neuron | shRNA | TR709372 |
| Slc30a8 | Down-Regulation of ZnT8 Expression in INS-1 Rat Pancreatic Beta Cells Reduces Insulin Content and Glucose-Inducible Insulin Secretion | PLoS ONE 4(5):e5679, 2009 | shRNA | TR708553 |
| SLC35A2 | Aberrant Expression of Solute Carrier Family 35 Member A2 Correlates With Tumor Progression in Breast Cancer | In Vivo | shRNA | TL309328 |
| SLC36A4 | Tumor-Repopulating Cells Induce PD-1 Expression in CD8+T Cells by Transferring Kynurenine and AhR Activation | Cancer Cell | shRNA | TG507107 |
| SLC39A12 | Role of zinc transporter ZIP12 in susceptibility-weighted brain magnetic resonance imaging (MRI) phenotypes and mitochondrial function | FASEB J. | shRNA | TF508163 |
| SLC39A12 | Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12) | PNAS, Jun 2013; 110: 9903 - 9908. | shRNA | TG301572 |
| SLC39A4 | ZIP4 Regulates Pancreatic Cancer Cell Growth by Activating IL-6/STAT3 Pathway through Zinc Finger Transcription Factor CREB | Clin. Cancer Res., Mar 2010; 16: 1423 - 1430 | shRNA | TR317306 |
| SLC39A4 | Down-regulation of ZIP4 by RNA Interference Inhibits Pancreatic Cancer Growth and Increases the Survival of Nude Mice with Pancreatic Cancer Xenografts | Clin. Cancer Res., Oct 2009; 15: 5993 - 6001 | shRNA | TR317306 |
| Slc6a15 | Reduced Slc6a15 in Nucleus Accumbens D2-Neurons Underlies Stress Susceptibility | The Journal of Neuroscience | shRNA | TG505662 |
| SLC7A8 | Tumor-Repopulating Cells Induce PD-1 Expression in CD8+T Cells by Transferring Kynurenine and AhR Activation | Cancer Cell | shRNA | TG502853 |
| SLC9A3R1 | Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs | Cell Death Differ. | shRNA | TF316855 |
| SLC9A3R1 | NHERF1 Regulates Parathyroid Hormone Receptor Desensitization: Interference with ß-Arrestin Binding | Mol. Pharmacol., May 2009; 75: 1189 - 1197. | shRNA | TR316855 |
| SLC9A3R1 | NHERF1 Regulates Parathyroid Hormone Receptor Desensitization; Interference with -arrestin Binding | Mol. Pharmacol., Feb 2009; 10.1124/mol.108.054486. | shRNA | TR316855 |
| SLC9A3R1 | NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling | J Biol Chem. 2007 Dec 14;282(50):36214-22. | shRNA | TR316855 |
| SLC9A3R2 | Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport | J. Biol. Chem. | shRNA | TR309271 |
| SLC9A3R2 | Na/H Exchanger Regulatory Factors Control Parathyroid Hormone Receptor Signaling by Facilitating Differential Activation of G{alpha} Protein Subunits | J. Biol. Chem., Aug 2010; 285: 26976 - 26986 | shRNA | TR309271 |
| SLK | SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation | J. Cell Biol. | shRNA | TG320620 |
| SMAD2 | Suppression of canonical TGF-β signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis | Journal of molecular and cellular cardiology | shRNA | TR509694 |
| Smad2 | Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification | Cell Death and Differentiation | shRNA | TL710211 |
| SMAD2 | The transcription factor GLI1 interacts with SMAD proteins to modulate TGFß-induced gene expression in a PCAF-dependent manner | J. Biol. Chem. April 2014 | shRNA | TG309255 |
| Smad2 | Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells | Am J Physiol Cell Physiol, Jun 2011; 300: C1415 - C1421 | shRNA | TR309255 |
| Smad3 | Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells | Am J Physiol Cell Physiol, Jun 2011; 300: C1415 - C1421 | shRNA | TR309254 |
| SMAD4 | Protein kinase CK2 activation is required for transforming growth factor β-induced epithelial-mesenchymal transition | Mol Oncol | shRNA | TR309253 |
| SMAD4 | Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice | Gastroenterology | shRNA | TG309253 |
| SMAD4 | The transcription factor GLI1 interacts with SMAD proteins to modulate TGFß-induced gene expression in a PCAF-dependent manner | J. Biol. Chem. April 2014 | shRNA | TG309253 |
| Smad7 | microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition | Nat Commun, Jan 2014. | shRNA | TG320409 |
| SMARCE1 | SWI/SNF Regulates the Cellular Response to Hypoxia | J. Biol. Chem., Feb 2009; 284: 4123 - 4131 | shRNA | TR309242 |
| SMG1 | Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival | Clin. Cancer Res., Mar 2012; 18: 1257 - 1267. | shRNA | TR318864 |
| SMN1 | iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases | JCI Insight | shRNA | TR301496 |
| Smo | Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals. | PLoS biology | shRNA | TG510788 |
| SMO | Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing | Nature Neuroscience (29 November 2009) | shRNA | TR309234 |
| SMPDL3B | Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis | Science Translational Medicine, Jun 2011; 3: 85ra46 | shRNA | TR309229 |
| Smurf1 | Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages. | Nature communications | shRNA | TL505101 |
| SNAI1 | CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells | International journal of molecular sciences | shRNA | TR309226 |
| SNAI1 | Inflammatory mediators drive metastasis and drug resistance in head and neck squamous cell carcinoma | Laryngoscope | shRNA | TG309226 |
| SNAI1 | BMK1 Kinase Suppresses Epithelial–Mesenchymal Transition through the Akt/GSK3ß Signaling Pathway | Cancer Res., Mar 2012; 72: 1579 - 1587. | shRNA | TR309226 |
| SNAI1 | Role of {Delta}Np63{gamma} in Epithelial to Mesenchymal Transition | J. Biol. Chem., Feb 2011; 286: 3915 - 3924 | shRNA | TG309226 |
| SNAI1 | Proinflammatory Mediators Upregulate Snail in Head and Neck Squamous Cell Carcinoma | Clin. Cancer Res., Oct 2009; 15: 6018 - 6027 | shRNA | TR309226 |
| SNAI2 | MicroRNA-124 suppresses Slug-mediated lung cancer metastasis | Eur Rev Med Pharmacol Sci | shRNA | TR309225 |
| SNAP25 | The SNARE Proteins SNAP25 and Synaptobrevin Are Involved in Endocytosis at Hippocampal Synapses | J. Neurosci., May 2013; 33: 9169 - 9175. | shRNA | TF711123 |
| SNX27 | Actin-Sorting Nexin 27-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling | J. Biol. Chem. | shRNA | TF301468 |
| SOCS3 | Human ß-defensin-2 enhances IFN-{gamma} and IL-10 production and suppresses IL-17 production in T cells | J. Leukoc. Biol., Jun 2011; 89: 935 - 944 | shRNA | TR316847 |
| SOD2 | Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells | Toxicol. Appl. Pharmacol. | shRNA | TG309190 |
| SOD2 | Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells | Toxicol. Appl. Pharmacol. | shRNA | TR309190 |
| SOD2 | Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis | J. Biol. Chem. | shRNA | TG309190 |
| SOD2 | Mitochondrial superoxide dismutase has a pro-tumorigenic role in ovarian clear cell carcinoma | Cancer Res. | shRNA | TG309190 |
| SOD2 | Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development | J. Biol. Chem. | shRNA | TG309190 |
| Sort1 | Sortilin regulates sorting and secretion of Sonic hedgehog | J. Cell. Sci. | shRNA | TR502101 |
| SORT1 | Sortilin regulates progranulin action in castration-resistant prostate cancer cells | Endocrinology | shRNA | TG309180 |
| SOX2 | Efficient extravasation of tumor-repopulating cells depends on cell deformability | Sci Rep | shRNA | TG515613 |
| SOX2 | Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming | Stem Cell Reports | shRNA | TG515613 |
| SOX2 | SOX2 expression in the developing, adult, as well as, diseased prostate | Prostate Cancer Prostatic Dis. | shRNA | TR309173 |
| Sox2 | Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression | Nat Commun | shRNA | TG515613 |
| SOX4 | SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells | Mol. Cancer | shRNA | TF315513 |
| SOX4 | Down-regulated SOX4 expression suppresses cell proliferation, metastasis and induces apoptosis in Xuanwei female lung cancer patients | J. Cell. Biochem. | shRNA | TG315513 |
| SOX4 | The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells | Development, Feb 2013; 140: 740 - 750. | shRNA | TF315513 |
| Sox9 | Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths | Cell reports | shRNA | TF511411 |
| SOX9 | Oncogenicity of the Developmental Transcription Factor Sox9 | Cancer Res., Mar 2012; 72: 1301 - 1315. | shRNA | TR309170 |
| SP1 | The Specificity Protein Factor Sp1 Mediates Transcriptional Regulation of P2X7 Receptors in the Nervous System | J. Biol. Chem., Dec 2012; 287: 44628 - 44644. | shRNA | TF502115 |
| Sp7 | Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths | Cell reports | shRNA | TF514041 |
| SP7 | Antagonistic interactions between osterix and pyrophosphate during cementum formation | Bone | shRNA | TG514041 |
| SPAG11A | Transgenesis and active immunization mediated reduction of sperm associated antigen 11A mRNA and protein levels affect fecundity in the rat | Theriogenology | shRNA | TG713093 |
| SPARCL1 | Methylation of SPARCL1 Is Associated with Oncologic Outcome of Advanced Upper Urinary Tract Urothelial Carcinoma | Int J Mol Sci | shRNA | TG309157 |
| SPC24 | SPC24 promotes osteosarcoma progression by increasing EGFR/MAPK signaling | Oncotarget | shRNA | TG301421 |
| SPC24 | SPC24 is critical for anaplastic thyroid cancer progression | Oncotarget | shRNA | TR301421 |
| Sphk1 | Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis | Carcinogenesis | shRNA | TF512690 |
| SPHK1 | Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer | J. Cancer Res. Clin. Oncol | shRNA | TR301413 |
| Sphk1 | Inducible IL-33 expression by mast cells is regulated by a calcium-dependent pathway | Journal of immunology (Baltimore, Md. : 1950) | shRNA | TL512690 |
| Sphk1 | Inducible IL-33 expression by mast cells is regulated by a calcium-dependent pathway | Journal of immunology (Baltimore, Md. : 1950) | shRNA | TF512690 |
| Sphk1 | Inducible IL-33 Expression by Mast Cells Is Regulated by a Calcium-Dependent Pathway | J. Immunol., Oct 2012; 189: 3421 - 3429. | shRNA | TG301413 |
| Sphk2 | Inducible IL-33 expression by mast cells is regulated by a calcium-dependent pathway | Journal of immunology (Baltimore, Md. : 1950) | shRNA | TL701575 |
| Sphk2 | Inducible IL-33 Expression by Mast Cells Is Regulated by a Calcium-Dependent Pathway | J. Immunol., Oct 2012; 189: 3421 - 3429. | shRNA | TG301412 |
| Sphkap | Neuronal ER-plasma membrane junctions couple excitation to Ca 2+ -activated PKA signaling | Nature Communications | shRNA | TL708390 |
| Spi1 | Alzheimer\'s-associated PU.1 expression levels regulate microglial inflammatory response | Neurobiology of disease | shRNA | TG502008 |
| Spi1 | A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease | Nat. Neurosci. | shRNA | TG502008 |
| SPI1 | A common haplotype lowers SPI1 (PU. 1) expression in myeloid cells and delays age at onset for Alzheimer's disease | bioRxiv | shRNA | TG502008 |
| SPI1 | Repression of primitive erythroid program is critical for the initiation of multi-lineage hematopoiesis in mouse development | J. Cell. Physiol. | shRNA | TG502008 |
| SPP1 | Identification of a Biphasic Role for Genistein in the Regulation of Prostate Cancer Growth and Metastasis | Cancer Res., Apr 2009; 69: 3695 - 3703. | shRNA | TR309135 |
| SPRY2 | Regulation of vascular signalling by nuclear Sprouty2 in fetal lung epithelial cells: Implications for co-ordinated airway and vascular branching in lung development | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | shRNA | TR309130 |
| SPRY2 | Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3 | Leukemia | shRNA | TG515588 |
| Spry4 | Suppression of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis | PLoS ONE. 2009; 4(5): e5467 | shRNA | TR509780 |
| SPTAN1 | α-Fodrin is required for the organization of functional microtubules during mitosis | Cell Cycle | shRNA | TR309127 |
| SPTBN1 | Transcriptional Regulation of STAT3 by SPTBN1 and SMAD3 in HCC Through cAMP-Response Element-Binding Proteins ATF3 and CREB2* | Carcinogenesis | shRNA | TR301396 |
| SQSTM1 | Enhanced Sensitivity to NVP-BEZ235 by Inhibition of p62/SQSTM1 in Human Bladder Cancer KoTCC-1 Cells Both In Vitro and In Vivo | In Vivo | shRNA | TR309121 |
| SQSTM1 | Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane | Toxicol. Appl. Pharmacol. | shRNA | TG309121 |
| SQSTM1 | Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis | J. Biol. Chem. | shRNA | TG309121 |
| SR30004 | Liver Molecular Mechanisms Involved in Type 2 Diabetes: An Investigation Using Roux-en Y Gastric Bypass as a Human Model of Diabetes Remission | Thesis July 2014 | shRNA | TR30015 |
| SRC | Lusianthridin Targeting of Lung Cancer Stem Cells via Src-STAT3 Suppression | Phytomedicine | shRNA | TR320529 |
| SRC | Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection | PLoS Pathog | shRNA | TR320529 |
| SRC | alpha3/4 Fucosyltransferase 3-Dependent Synthesis of Sialyl Lewis A on CD44 Variant Containing Exon 6 Mediates Polymorphonuclear Leukocyte Detachment from Intestinal Epithelium during Transepithelial Migration | J Immunol. 2013 Nov 1;191(9):4804-17 | shRNA | TG320529 |
| SRC | TR3 Modulates Platinum Resistance in Ovarian Cancer | Cancer Res., Aug 2013; 73: 4758 - 4769. | shRNA | TG320529 |
| SREBF1 | Myostatin induces insulin resistance via Cblb-mediated degradation of IRS1 in response to high calorie diet intake | J. Biol. Chem., Jan 2014. | shRNA | TG514167 |
| SREBF1 | Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells | Mol. Cancer Res., Jan 2012; 10: 133 - 142. | shRNA | TR309117 |
| SREBF1 | Androgen Receptor Survival Signaling Is Blocked by Anti-ß2-microglobulin Monoclonal Antibody via a MAPK/Lipogenic Pathway in Human Prostate Cancer Cells | J. Biol. Chem., Mar 2010; 285: 7947 - 7956 | shRNA | TR309117 |
| Srebf2 | Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity | Genes & Development | shRNA | TG510683 |
| SRRT | ARS2 is required for retinal progenitor cell S-phase progression and Müller glial cell fate specification | Biochem. Cell Biol. | shRNA | TG514443 |
| SRRT | Mutagenesis of ARS2 Domains to Assess Possible Roles in Cell Cycle Progression, MicroRNA and Replication-dependent Histone mRNA Biogenesis | Mol. Cell. Biol. | shRNA | TG514443 |
| SRSF1 | Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine-arginine-rich Protein ASF/SF2 | J. Cell. Biochem. | shRNA | TR309496 |
| SRSF5 | SRSF5 Regulates the Expression of BQ323636.1 to Modulate Tamoxifen Resistance in ER-Positive Breast Cancer. | Cancers | shRNA | TL309487 |
| St6galnac4 | Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche | Cancer Discov | shRNA | TG502032 |
| STARD4 | Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis | Biochim Biophys Acta Mol Cell Biol Lipids | shRNA | TG301353 |
| STARD4 | STARD4 abundance regulates sterol transport and sensing | Mol. Biol. Cell, Nov 2011; 22: 4004 - 4015. | shRNA | TR506047 |
| STAT1 | STAT1‑HDAC4 signaling induces epithelial‑mesenchymal transition and sphere formation of cancer cells overexpressing the oncogene, CUG2 | Oncol. Rep. | shRNA | TG301349 |
| STAT1 | Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas | J. Clin. Invest | shRNA | TG502153 |
| STAT1 | STAT1 drives tumor progression in serous papillary endometrial cancer | Cancer Res. | shRNA | TG301349 |
| STAT1 | A switch from hBrm to Brg1 at IFN?-activated sequences mediates the activation of human genes | Cell Research 20, 1345-1360 (16 November 2010) doi:10.1038/cr.2010.155 Original Article | shRNA | |
| STAT1 | Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. | Cellular signalling | shRNA | TR301349 |
| Stat3 | Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis | Molecular Oncology | shRNA | TF502154 |
| STAT3 | ß-cell mass restoration by α7-nicotinic acetylcholine receptor activation | J. Biol. Chem. | shRNA | TG709368 |
| STAT3 | GLI3 knockdown decreases stemness, cell proliferation and invasion in oral squamous cell carcinoma | Int. J. Oncol. | shRNA | TG301348 |
| STAT3 | Regulation of endometrial cell proliferation by estrogen-induced BDNF signaling pathway | Gynecol. Endocrinol | shRNA | TR301348 |
| STAT3 | Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism | Sci Rep | shRNA | TR301348 |
| STAT3 | Rig-G is a growth inhibitory factor of lung cancer cells that suppresses STAT3 and NF-κB | Oncotarget | shRNA | TR301348 |
| STAT3 | Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling | Oncotarget | shRNA | TR301348 |
| STAT3 | Feed forward reciprocal activation of PAFR and STAT3 regulates epithelial-mesenchymal transition in non-small cell lung cancer | Cancer Res. | shRNA | TR301348 |
| STAT3 | Autophagy inhibition by sustained over-production of IL-6 contributes to arsenic-induced carcinogenesis | Cancer Res. | shRNA | TF301348 |
| Stim1 | Activity-dependent endoplasmic reticulum Ca 2+ uptake depends on Kv2.1-mediated endoplasmic reticulum/plasma membrane junctions to promote synaptic transmission | Proceedings of the National Academy of Sciences of the United States of America | shRNA | TR707032 |
| STIM1 | Role of STIM2 and Orai proteins in regulating TRPC1 channel activity upon calcium store depletion | Cell calcium | shRNA | TG309049 |
| STIM1 | Axonal Endoplasmic Reticulum Ca(2+) Content Controls Release Probability in CNS Nerve Terminals | Neuron | shRNA | TR707032 |
| STIM1 | Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation | Immunity, Inflammation and Disease | shRNA | TF502160 |
| STIM1 | STIM1 and STIM2 Proteins Differently Regulate Endogenous Store-operated Channels in HEK293 Cells | J. Biol. Chem. | shRNA | TR309049 |
| STIM1 | JBC Papers in Press. Published on December 22, 2014 as Manuscript M114. 601856 | The Journal of Biological Chemistry | shRNA | TR309049 |
| STIM1 | Amplified lipid rafts of malignant cells constitute a target for inhibition of aberrantly active NFAT and melanoma tumor growth by the aminobisphosphonate zoledronic acid | Carcinogenesis | shRNA | TG309049 |
| STIM1 | Molecular mechanisms of spontaneous and directed mast cell motility | J. Leukoc. Biol., Nov 2012; 92: 1029 - 1041. | shRNA | TG309049 |
| STIM1 | Lipid rafts couple store-operated Ca2+ entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth | Carcinogenesis, Feb 2012; 10.1093/carcin/bgs021. | shRNA | TR309049 |
| Stim1 | Mitochondria depletion abolishes agonist-induced Ca2+ plateau in airway smooth muscle cells - potential role of H2O2 | Am J Physiol Lung Cell Mol Physiol, Nov 2009; 10.1152/ajplung.00134.2009 | shRNA | TR707032 |
| STIM1 | Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration | FASEB J, Apr 2009; 10.1096/fj.09-131128. | shRNA | TR309049 |
| STIM1 | Store-operated cyclic AMP signalling mediated by STIM1 | Nature Cell Biology 11, 433-442 (15 March 2009) | shRNA | TR309049 |
| STIM1 | Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line | J. Immunol., Feb 2008; 180: 2233 - 2239. | shRNA | TR309049 |
| STIP1 | Stress-induced phosphoprotein 1 promotes pancreatic cancer progression through activation of the FAK/AKT/MMP signaling axis. | Pathology, research and practice | shRNA | TL309048 |
| STK11 | Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability | Transl Psychiatry. 2013 Oct 22;3:e317 | shRNA | TG706613 |
| STMN2 | The landscape of multiscale transcriptomic networks and key regulators in Parkinson\'s disease | Nat Commun | shRNA | TF511127 |
| STRIP2 | STRIP2 is indispensable for the onset of embryonic stem cell differentiation | olecular Therapy: Methods & Clinical Developmen | shRNA | TR508344 |
| Strip2 | Fam40b is required for lineage commitment of murine embryonic stem cells | Cell Death Dis July 2014 | shRNA | TR508344 |
| STUB1 | Hsp90 inhibition renders iNOS aggregation and the clearance of iNOS aggregates by proteasomes requires SPSB2 | Free Radic. Biol. Med. | shRNA | TG316909 |
| STUB1 | A Critical Role for CHIP in the Aggresome Pathway | Mol. Cell. Biol., Jan 2009; 29: 116 - 128. | shRNA | TR316909 |
| SUMO1 | Adenosine Signaling Mediates SUMO-1 Modification of IB during Hypoxia and Reoxygenation | J. Biol. Chem., May 2009; 284: 13686 - 13695. | shRNA | TR316774 |
| SUN1 | Fluorescence Fluctuation Spectroscopy Reveals Differential SUN Protein Oligomerization In Living Cells | Mol. Biol. Cell | shRNA | TF300647 |
| SUN2 | Fluorescence Fluctuation Spectroscopy Reveals Differential SUN Protein Oligomerization In Living Cells | Mol. Biol. Cell | shRNA | TF300646 |
| SUOX | Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells | Oncotarget | shRNA | TG309008 |
| SUPT5H | A role for the RNA pol II–associated PAF complex in AID-induced immune diversification | J. Exp. Med., Oct 2012; 209: 2099 - 2111. | shRNA | TG309005 |
| SUPT5H | A role for the RNA pol II–associated PAF complex in AID-induced immune diversification | J. Exp. Med., Sep 2012; 10.1084/jem.20112145. | shRNA | TR309005 |
| Sv2c | Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinsons disease | bioRxiv | shRNA | TR711401 |
| Svbp | Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. | Science (New York, N.Y.) | shRNA | TL517601 |
| SYK | Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection | PLoS Pathog | shRNA | TR320543 |
| SYK | The Spleen Tyrosine Kinase (syk) Regulates Alzheimer's Aß Production and Tau Hyperphosphorylation | J. Biol. Chem. | shRNA | TG320543 |
| Syngr3 | Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau. | Neuron | shRNA | TL502195 |
| SYNGR3 | Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau | Neuron | shRNA | TF705557 |
| TACSTD2 | Trop2 enhances invasion of thyroid cancer by inducing MMP2 through ERK and JNK pathways | BMC Cancer | shRNA | TR308966 |
| TAGLN2 | Oncogenic transgelin-2 is differentially regulated in isocitrate dehydrogenase wild-type vs. mutant gliomas | Oncotarget | shRNA | TG316819 |
| TAP1 | Cellular and Molecular Requirements for the Selection of In Vitro–Generated CD8 T Cells Reveal a Role for Notch | J. Immunol., Aug 2013; 191: 1704 - 1715. | shRNA | TG308949 |
| TAS2R14 | Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin | International Journal of Oncology | shRNA | TL301238 |
| TAS2R14 | Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling | J. Biol. Chem. | shRNA | TR301238 |
| TBC1D23 | Homozygous Truncating Variants in TBC1D23 Cause Pontocerebellar Hypoplasia and Alter Cortical Development | Am. J. Hum. Genet. | shRNA | TR503947 |
| TBC1D9 | Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell-derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity | Mol Ther Nucleic Acids. 2013 Oct 1;2:e126 | shRNA | TF308932 |
| Tcf3 | Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. | Molecular cell | shRNA | TL510854 |
| TCF3 | Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. | Molecular cell | shRNA | TL308904 |
| Tcf4 | ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis | Genes & Development | shRNA | TG502233 |
| TDG | Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. | International journal of oncology | shRNA | TG316755 |
| TDP1 | Expression Of TDP-43 C-terminal fragments in vitro recapitulates pathological features of TDP-43 proteinopathies | J. Biol. Chem., Jan 2009; 10.1074/jbc.M809462200. | shRNA | TR308891 |
| TEAD2 | Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. | Molecular cell | shRNA | TL308887 |
| Tead2 | Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. | Molecular cell | shRNA | TR502250 |
| TERF2 | DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair | Mol. Cell. Biol., Jul 2009; 29: 3597 - 3604 | shRNA | TR308880 |
| TESK1 | Tesk1 Interacts with Spry2 to Abrogate Its Inhibition of ERK Phosphorylation Downstream of Receptor Tyrosine Kinase Signaling | J. Biol. Chem., Jan 2008; 283: 1679 - 1691. | shRNA | TR308879 |
| TET2 | TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System | Front Pharmacol | shRNA | TG303734 |
| Tet2 | Ten-Eleven Translocation-2 (Tet2) Is Involved in Myogenic Differentiation of Skeletal Myoblast Cells in Vitro | Sci Rep | shRNA | TR513547 |
| TFAM | Knockdown of TFAM in Tumor Cells Retarded Autophagic Flux through Regulating p53 Acetylation and PISD Expression | Cancers (Basel) 2020 | shRNA | TG316756 |
| TFAM | Down-regulation of TFAM increases the sensitivity of tumour cells to radiation via p53/TIGAR signalling pathway | J. Cell. Mol. Med. | shRNA | TG502265 |
| TFAM | Cyclooxygenase-2-Mediated Up-Regulation of Mitochondrial Transcription Factor A Mitigates the Radio-Sensitivity of Cancer Cells | Int J Mol Sci | shRNA | TG502265 |
| TFAM | HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells | Cancer Sci. | shRNA | TR316756 |
| TFAM | Mitochondrial transcription factor A regulated ionizing radiation-induced mitochondrial biogenesis in human lung adenocarcinoma A549 cells | J Radiat Res, May 2013; 10.1093/jrr/rrt046. | shRNA | TR316756 |
| TFEB | Mitochondrial Translocation of TFEB Regulates Complex I and Inflammation | SSRN Electronic Journal | shRNA | TF308867 |
| TFEB | Curcumin Analogue C1 Promotes Hex and Gal Recruitment to the Plasma Membrane via mTORC1-Independent TFEB Activation | Int J Mol Sci | shRNA | TR308867 |
| TFEB | Oncogenic H-Ras Up-Regulates Acid β-Hexosaminidase by a Mechanism Dependent on the Autophagy Regulator TFEB | PLOS ONE, Feb 2014. | shRNA | TR308867 |
| TGFB1 | Mesenchymal stem cells enhance tumorigenic properties of human glioblastoma through independent cell-cell communication mechanisms | Oncotarget | shRNA | TG308855 |
| TGFB1 | TGF Beta1 Expression Correlates with Survival and Tumor Aggressiveness of Prostate Cancer | Ann. Surg. Oncol. | shRNA | TG308855 |
| TGFB1 | TGF-ß1 mediates the radiation response of prostate cancer | J. Mol. Med. | shRNA | TG308855 |
| TGFB1 | Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production | Arthritis & Rheumatism Volume 60 Issue 5, Pages 1438 - 1450 | shRNA | TR308855 |
| TGFBR1 | Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells | J. Biol. Chem. | shRNA | TR709395 |
| TGFBR1 | The role of Alk-1 and Alk-5 in the mechanosensing of chondrocytes | Cell. Mol. Biol. Lett. | shRNA | TG709395 |
| TGFBR2 | Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells | J. Biol. Chem. | shRNA | TR711255 |
| Tgfbr2 | TGF-ß Signaling Regulates Cementum Formation through Osterix Expression | Sci Rep | shRNA | TR516186 |
| Tgfbr2 | Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer | Genome Biology | shRNA | TG516186 |
| tGFP | The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer | Nucleic Acids Res. | shRNA | TR30016 |
| THOC2 | THOC2 expression and its impact on 5-fluoro resistance in glioblastoma multiforme | American Journal of Cancer Research | shRNA | TL301111 |
| Thrap3 | Thrap3 promotes R-loop resolution via interaction with methylated DDX5 | Experimental & Molecular Medicine | shRNA | TL701343 |
| TIAM1 | Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis | Cell Rep | shRNA | TG511327 |
| TIMP1 | Regulation of soluble vascular endothelial growth factor receptor 1 secretion from human endothelial cells by tissue inhibitor of metalloproteinase 1 | Molecular Human Reproduction, doi:10.1093/molehr/gap053 | shRNA | TR308814 |
| TIMP3 | Mesenchymal Stem Cells Regulate Blood-Brain Barrier Integrity Through TIMP3 Release After Traumatic Brain Injury | Science Translational Medicine, Nov 2012; 4: 161ra150. | shRNA | TR308813 |
| Tissue | Imaging of motor-dependent transport in neuronal and nonneuronal cells at high spatial and temporal resolution | Methods in Cell Biology | shRNA | TR30007 |
| Tle1 | Transducin-like Enhancer of Split-1 (TLE1) Combines with Forkhead Box Protein G1 (FoxG1) to Promote Neuronal Survival | J. Biol. Chem., Apr 2012; 287: 14749 - 14759. | shRNA | TG511107 |
| TLE5 | Repression of HNF1a-mediated transcription by amino-terminal enhancer of split (AES) | Biochem. Biophys. Res. Commun. | shRNA | TR306804 |
| TLE5 | Amino-terminal Enhancer of Split (AES) Interacts with the Oncoprotein NUP98-HOXA9 and Enhances Its Transforming Ability | J. Biol. Chem., Nov 2011; 286: 38989 - 39001. | shRNA | TR306804 |
| TLK1 | The TLK1–MK5 Axis Regulates Motility, Invasion, and Metastasis of Prostate Cancer Cells | Cancers | shRNA | TL320623 |
| TLK1 | DNA damage response and repair data with pharmacological modulators of Tousled | Data in Brief | shRNA | TG320623 |
| TLR2 | Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis | MBio | shRNA | TR320553 |
| TLR4 | Atractylenolide-I Suppresses Tumorigenesis of Breast Cancer by Inhibiting Toll-Like Receptor 4-Mediated Nuclear Factor-κB Signaling Pathway | Frontiers in pharmacology | shRNA | TG320555 |
| TLR4 | Atractylenolide-I suppresses tumorigenesis of breast cancer by inhibiting toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway | Research Square | shRNA | TG320555 |
| TLR4 | Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production | Gut Microbes | shRNA | TG320555 |
| TLR4 | Cathelicidin senses enteric pathogen Salmonella typhimurium/LPS for colonic chemokine generation: a new innate immune role for a host defense peptide | bioRxiv | shRNA | TG320555 |
| TLR4 | Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells | Mol Med Rep | shRNA | TG320555 |
| TLR4 | HSV-2 Increases TLR4-Dependent Phosphorylated IRFs and IFN-ß Induction in Cervical Epithelial Cells | PLoS ONE e94806 9 4. April 2014 | shRNA | TG320555 |
| TLR4 | TLR4-MyD88/Mal-NF-kB Axis Is Involved in Infection of HSV-2 in Human Cervical Epithelial Cells | PLoS ONE e80327 | shRNA | TG320555 |
| TLR5 | Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis | MBio | shRNA | TR308792 |
| TLR7 | Toll-Like Receptor 7 Mediates Inflammation Resolution and Inhibition of Angiogenesis in Non-Small Cell Lung Cancer | Cancers | shRNA | TG301078 |
| TLR9 | Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis | MBio | shRNA | TR301076 |
| TM4SF5 | Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells | Hepatology | shRNA | TG308787 |
| TMEM106A | Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis | J. Cell. Mol. Med. | shRNA | TF301042 |
| Tmem106b | Lysosome size, motility and stress response regulated by Fronto-Temporal Dementia modifier TMEM106B | Molecular and cellular neurosciences | shRNA | TL504639 |
| Tmem126a | Novel transmembrane protein 126A (TMEM126A) Couples with CD137L Reverse Signals in Myeloid cells | Cellular signalling | shRNA | TL503575 |
| TMEM127 | Germline mutations in TMEM127 confer susceptibility to pheochromocytoma | Nature Genetics 42, 229-233 (14 February 2010) doi:10.1038/ng.533 Letter | shRNA | TR301024 |
| Tmem184a | Heparin Decreases in Tumor Necrosis Factor α (TNFα)-induced Endothelial Stress Responses Require Transmembrane Protein 184A and Induction of Dual Specificity Phosphatase 1 | The Journal of Biological Chemistry | shRNA | TL702927 |
| Tmem184a | Transmembrane Protein 184A Is a Receptor Required for Vascular Smooth Muscle Cell Responses to Heparin | The Journal of Biological Chemistry | shRNA | TL702927 |
| TMEM184A | Heparin decreases in TNFa;-induced endothelial stress responses require transmembrane protein 184A and induction of dual specificity phosphatase-1 | J. Biol. Chem. | shRNA | TG702927 |
| TMEM88 | Transmembrane protein 88 (TMEM88) promoter hypomethylation is associated with platinum resistance in ovarian cancer | Gynecol. Oncol. | shRNA | TR318781 |
| Tmod2 | Down-regulated in renal cell carcinoma 1 (DRR1) regulates axon outgrowth during hippocampal neuron development. | Biochemical and biophysical research communications | shRNA | TL711420 |
| TMOD2 | Down-regulated in renal cell carcinoma 1 (DRR1) regulates axon outgrowth during hippocampal neuron development | Biochemical and biophysical research communications | shRNA | TG711420 |
| TNF | Overexpression of CCN1 in Het1A cells attenuates bile-induced esophageal metaplasia through suppressing non-canonical NFκB activation | Cytokine | shRNA | TR318768 |
| TNF | Transmembrane TNF-alpha promotes chemoresistance in breast cancer cells | Oncogene | shRNA | TG318768 |
| TNF | Targeting Transmembrane TNF-a Suppresses Breast Cancer Growth | Cancer Res., Jul 2013; 73: 4061 - 4074. | shRNA | TG318768 |
| Tnfaip2 | Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy | Autophagy | shRNA | TL513846 |
| TNFAIP3 | Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure | Digestive and Liver Disease | shRNA | TR320557 |
| TNFAIP6 | Acute and Temporal Expression of TNF-a-stimulated Gene 6 Product,TSG-6,in Mesenchymal Stem Cells Creates Microenvironments Required for Their Successul Transplantation into the Muscle Tissue | J. Biol. Chem. | shRNA | TF517014 |
| TNFRSF10C | Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure | Digestive and Liver Disease | shRNA | TR308740 |
| TNFRSF10D | Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure | Digestive and Liver Disease | shRNA | TR308739 |
| TNFRSF11B | Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure | Digestive and Liver Disease | shRNA | TR308738 |
| TNFRSF1B | WISP1, a Pro-mitogenic, Pro-survival Factor, Mediates Tumor Necrosis Factor- (TNF-)-stimulated Cardiac Fibroblast Proliferation but Inhibits TNF--induced Cardiomyocyte Death | J. Biol. Chem., May 2009; 284: 14414 - 14427 | shRNA | TR308733 |
| TNFSF10 | Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure | Digestive and Liver Disease | shRNA | TR308728 |
| TNFSF10 | CCN1 sensitizes esophageal cancer cells to TRAIL-mediated apoptosis | Exp. Cell Res. | shRNA | TR308728 |
| TNIK | Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK | J. Pharmacol. Exp. Ther. | shRNA | TF320665 |
| TNK2 | ACK1 promotes hepatocellular carcinoma progression via downregulating WWOX and activating AKT signaling | Int. J. Oncol. | shRNA | TR320634 |
| TNKS1BP1 | Endothelial p130cas confers resistance to anti-angiogenesis therapy | Cell reports | shRNA | TL300907 |
| TNMD | Effects of X-chromosome Tenomodulin Genetic Variants on Obesity in a Children's Cohort and Implications of the Gene in Adipocyte Metabolism | Sci Rep | shRNA | TR300905 |
| TNPO3 | Knockdown of the host cellular protein transportin 3 attenuates prototype foamy virus infection | Biosci. Biotechnol. Biochem. | shRNA | TG315644 |
| TOP2B(GFP vector) | Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements | Nature Genetics (4 July 2010) doi:10.1038/ng.613 Article | shRNA | |
| TOPBP1 | ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress | Cell July 2014 | shRNA | TR308695 |
| TOX | MiR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation | Sci Adv | shRNA | TG507539 |
| TOX3 | TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex | J. Cell Sci., Jan 2011; 124: 252 - 260 | shRNA | TR300899 |
| TP53 | COUP-TFII Overexpression Inhibits Cell Proliferation and Invasion via Increased Expression of p53 and PTEN and Decreased Akt Phosphorylation in Human Colorectal Cancer SNU-C4 Cells | Anticancer Res. | shRNA | TG320558 |
| TP53 | TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background | Front Oncol | shRNA | TR320558 |
| TP53 | p53-Dependent and -Independent Responses of Cells Challenged by Photosensitization | Photochem. Photobiol. | shRNA | TG320558 |
| TP53 | p53 is essential for embelin-induced apoptosis in p53-wildtype prostate cancer cells | Int J Clin Exp Med | shRNA | TR320558 |
| TP53 | Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways | PLoS ONE | shRNA | TG320558 |
| TP53 | Harnessing the p53-PUMA Axis to Overcome DNA Damage Resistance in Renal Cell Carcinoma | Neoplasia | shRNA | TR320558 |
| TP53 | Oncomorphic TP53 Mutations in Gynecologic Cancers Lose the Normal Protein: Protein Interactions with the microRNA Microprocessing Complex | Journal of Cancer Therapy April 2014 | shRNA | TR320558 |
| TP53 | Oncomorphic Tp53 mutations in advanced serous ovarian carcinomas | Thesis | shRNA | TF320558 |
| TP53 | Gene Expression Profiles Resulting from Stable Loss of p53 Mirrors Its Role in Tissue Differentiation | PLOS ONE e82494 | shRNA | TG320558 |
| TP53 | Deacetylation of p53 induces autophagy by suppressing Bmf expression | J. Cell Biol., Apr 2013; 201: 427 - 437. | shRNA | TG320558 |
| TP53 | Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival | Clin. Cancer Res., Mar 2012; 18: 1257 - 1267. | shRNA | TR320558 |
| TP53BP1 | Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients | Oncogene | shRNA | TR308691 |
| TP53BP1 | MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection | Nature | shRNA | TF308691 |
| TP53BP1 | MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection | Nature | shRNA | TR308691 |
| TP63 | TGFß3 Regulates Periderm Removal through ?Np63 in the Developing Palate | J. Cell. Physiol. | shRNA | TR308688 |
| TP63 | OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation | Cell Death Dis, Jan 2014. | shRNA | TG308688 |
| TP73 | The p53 family member p73 modulates the pro-proliferative role of IGFBP3 in short children born SGA | Mol. Biol. Cell | shRNA | TR308689 |
| Tpcn2 | VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling | Proc. Natl. Acad. Sci. U.S.A. | shRNA | TR300883 |
| TPK1 | TPK1 as a predictive marker for the anti-tumour effects of simvastatin in gastric cancer | Pathol. Res. Pract. | shRNA | TG300880 |
| Tpp2 | A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport | Cell reports | shRNA | TL711260 |
| TPR | Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways | PLoS ONE | shRNA | TG308677 |
| TR20003 | Circadian Modulation of 8-Oxoguanine DNA Damage Repair | Sci Rep | shRNA | TR20003 |
| TR20003 | Feed forward reciprocal activation of PAFR and STAT3 regulates epithelial-mesenchymal transition in non-small cell lung cancer | Cancer Res. | shRNA | TR20003 |
| TR20003 | Actin-Modulating Protein Cofilin Is Involved in the Formation of Measles Virus Ribonucleoprotein Complex at the Perinuclear Region | J. Virol. | shRNA | TR20003 |
| TR20003 | SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells | Autophagy | shRNA | TR20003 |
| TR20003 | STX13 regulates cargo delivery from recycling endosomes during melanosome biogenesis | J. Cell. Sci. | shRNA | TR20003 |
| TR20003 | TNF Apoptosis Protection Fraction (TAPF) prevents apoptosis induced by TNF, but not by Fas or TRAIL, via NF-?B-induced increase in cFLIP | Cytokine | shRNA | TR20003 |
| TR20003 | Different states of integrin LFA-1 aggregation are controlled through its association with tetraspanin CD9 | Biochim. Biophys. Acta | shRNA | TR20003 |
| TR20003 | Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells | Br. J. Cancer | shRNA | TR20003 |
| TR20003 | Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents | PLoS ONE | shRNA | TR20003 |
| TR20003 | Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma | Int. J. Oncol. | shRNA | TR20003 |
| TR20003 | STING agonists induce an innate antiviral immune response against hepatitis B virus | Antimicrob. Agents Chemother. | shRNA | TR20003 |
| TR30002 | Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche | Cancer Discov | shRNA | TR30002 |
| TR30003 | A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy | Cell Death Dis | shRNA | TR30003 |
| TR30003 | TNF Apoptosis Protection Fraction (TAPF) prevents apoptosis induced by TNF, but not by Fas or TRAIL, via NF-?B-induced increase in cFLIP | Cytokine | shRNA | TR30003 |
| TR30007 | Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus | J. Clin. Invest. | shRNA | TR30007 |
| TR30007 | Effect of Co-transfection of Anti-myostatin shRNA Constructs in Caprine Fetal Fibroblast Cells | Anim. Biotechnol. | shRNA | TR30007 |
| TR30007 | SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response | J. Clin. Invest. | shRNA | TR30007 |
| TR30007 | Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways | PLoS ONE | shRNA | TR30007 |
| TR30007 | Effects of Ezrin and Heat Shock Protein 70 on Apoptosis and Proliferation of Human Osteosarcoma Cells | Orthop Surg | shRNA | TR30007 |
| TR30007 | Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation | Sci Rep | shRNA | TR30007 |
| TR30007 | Cellular and subcellular imaging of motor protein-based behavior in embryonic rat brain | Methods in Cell Biology | shRNA | TR30007 |
| TR30007 | Construction of DKK1-siRNA eukaryotic expression vectors and the therapeutic effect on osteoporotic rats | Chinese Journal of Osteoporosis | shRNA | TR30007 |
| TR30007 | Knockdown of the host cellular protein transportin 3 attenuates prototype foamy virus infection | Biosci. Biotechnol. Biochem. | shRNA | TR30007 |
| TR30007 | Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis | Cell. Microbiol. | shRNA | TR30007 |
| TR30007 | Biologic Roles of Estrogen Receptor-ß and Insulin-Like Growth Factor-2 in Triple-Negative Breast Cancer | BioMed Research International | shRNA | TR30007 |
| TR30007 | PDLIM5 mediates PKCe translocation in PMA-induced growth cone collapse | Cell. Signal. | shRNA | TR30007 |
| TR30007 | Memory and PTPIP51 - A new protein in hippocampus and cerebellum | Mol. Cell. Neurosci. | shRNA | TR30007 |
| TR30012 | Role of Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2) In Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes | Drug Metab. Dispos. | shRNA | TR30012 |
| TR30012 | Forkhead box protein A1 is a prognostic predictor and promotes tumor growth of gastric cancer | Onco Targets Ther | shRNA | TR30012 |
| TR30012 | Signaling mechanisms coupled to CXCL12/CXCR4-mediated cellular proliferation are PTEN-dependent | Am J Clin Exp Urol | shRNA | TR30012 |
| TR30012 | STING agonists induce an innate antiviral immune response against hepatitis B virus | Antimicrob. Agents Chemother. | shRNA | TR30012 |
| TR30012 | a-Actinin-4 Is Required for Amoeboid-type Invasiveness ofMelanoma Cells* | JOURNAL OF BIOLOGICAL CHEMISTRY | shRNA | TR30012 |
| TR30012 | AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells | Biochem. Pharmacol. July 2014 | shRNA | TR20003 |
| TR30013 | SATB2 expression increased anchorage-independent growth and cell migration in human bronchial epithelial cells | Toxicol. Appl. Pharmacol. | shRNA | TR30013 |
| TR30013 | SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response | J. Clin. Invest. | shRNA | TR30013 |
| TR30013 | A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/ß-catenin signalling pathway | Cell Discovery | shRNA | TR30013 |
| TR30013 | Endogenous Nodal promotes melanoma undergoing epithelial-mesenchymal transition via Snail and Slug in vitro and in vivo | Am J Cancer Res | shRNA | TR30013 |
| TR30013 | Activation of peroxisome proliferator-activated receptor a stimulates ADAM10-mediated proteolysis of APP | Proc. Natl. Acad. Sci. U.S.A. | shRNA | TR30013 |
| TR30013 | Knockdown of the host cellular protein transportin 3 attenuates prototype foamy virus infection | Biosci. Biotechnol. Biochem. | shRNA | TR30013 |
| TR30013 | Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis | Cell. Microbiol. | shRNA | TR30013 |
| TR30013 | Sphingomyelin Synthase 1 Regulates Neuro-2a Cell Proliferation and Cell Cycle Progression Through Modulation of p27 Expression and Akt Signaling | Mol. Neurobiol. | shRNA | TR30007 |
| TR30014 | Imaging of motor-dependent transport in neuronal and nonneuronal cells at high spatial and temporal resolution | Methods in Cell Biology | shRNA | TR30014 |
| TR30014 | Cellular and subcellular imaging of motor protein-based behavior in embryonic rat brain | Methods in Cell Biology | shRNA | TR30014 |
| TR30014 | The vesicular nucleotide transporter (VNUT) is involved in the extracellular ATP effect on neuronal differentiation | Purinergic Signal. | shRNA | TR30014 |
| TR30014 | Dual Expression of shAkt1 and Pdcd4 Suppresses Lung Tumorigenesis in K-rasLA1 Mice | Anticancer Res. | shRNA | TR30014 |
| TR30014 | S100 Calcium-Binding Protein A6 Promotes Epithelial-Mesenchymal Transition through ß-Catenin in Pancreatic Cancer Cell Line | PLoS ONE | shRNA | TR30014 |
| TR30014 | ADAM8 as a drug target in pancreatic cancer | Nat Commun | shRNA | TR30014 |
| TR30014 | RNA-Processing Protein TDP-43 Regulates FOXO-Dependent Protein Quality Control in Stress Response | PLoS Genet. | shRNA | TR30014 |
| TR30015 | Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription | PLoS Biol. | shRNA | TR30015 |
| TR30018 | HO-1/CO system and embryonic stem cell differentiation and maturation into cardiomyocytes | Antioxid. Redox Signal. | shRNA | TR30018 |
| TR30018 | The Novel Gene CRNDE Encodes a Nuclear Peptide (CRNDEP) Which Is Overexpressed in Highly Proliferating Tissues | PLoS ONE | shRNA | TR30018 |
| TR30018 | p38 MAPK down-regulates fibulin 3 expression through methylation of gene regulatory sequences. Role in migration and invasion | J. Biol. Chem. | shRNA | TR30018 |
| TR30021 | Targeting the MLL complex in castration-resistant prostate cancer | Nat. Med. | shRNA | TR30021 |
| TR30023 | Protein composition and movements of membrane swellings associated with primary cilia | Cell. Mol. Life Sci. | shRNA | TR30023 |
| TR30032 | Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation | J. Neurosci. | shRNA | TR30032 |
| TR313235 | HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects | Hum. Mol. Genet., Feb 2011; 20: 553 - 579 | shRNA | |
| TRADD | Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure | Digestive and Liver Disease | shRNA | TR320590 |
| Transfection | Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers, FGF22 and FGF7 | J. Cell. Sci. | shRNA | TR30014 |
| TRIL | Toll-like Receptor 3 (TLR3) Signaling Requires TLR4 Interactor with Leucine-rich Repeats (TRIL) | J. Biol. Chem., Nov 2011; 286: 38795 - 38804. | shRNA | TR315701 |
| TRIM28 | Expression of tripartite motif-containing protein 28 in primary breast carcinoma predicts metastasis and is involved in the stemness, chemoresistance, and tumor growth | Tumour Biol. | shRNA | TG502285 |
| TRIM28 | Exonuclease-1 interacts with the transcriptional co-repressor KAP1 | Matters | shRNA | TR320633 |
| Trim32 | TRIM32 overexpression improves chemoresistance through regulation of mitochondrial function in non-small-cell lung cancers | OncoTargets and therapy | shRNA | TL701612 |
| TRIM39 | TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process | Experimental Cell Research Volume 315, Issue 7, 15 April 2009, Pages 1313-1325 | shRNA | TR300845 |
| TRIM72 | Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair | JCI Insight | shRNA | TG517706 |
| TRIM8 | TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background | Front Oncol | shRNA | TR300821 |
| TRIM8 | TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours | Mol. Cancer | shRNA | TR300821 |
| TRIM8 | TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma | Oncotarget | shRNA | TR300821 |
| TRIP10 | Collective membrane dynamics emerging from curvature-dependent spatial coupling | bioRxiv | shRNA | TG712260 |
| Trp53 | Maternal Obesity Programs Senescence Signaling and Glucose Metabolism in Osteo-Progenitors From Rat and Human. | Endocrinology | shRNA | TG500002 |
| TRPC1 | Molecular mechanisms of spontaneous and directed mast cell motility | J. Leukoc. Biol., Nov 2012; 92: 1029 - 1041. | shRNA | TG308629 |
| TRPC1 | Ca2+ Waves Initiate Antigen-Stimulated Ca2+ Responses in Mast Cells | J. Immunol., Nov 2009; 183: 6478 - 6488 | shRNA | TR308629 |
| TRPC1 | Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration | FASEB J, Apr 2009; 10.1096/fj.09-131128. | shRNA | TR308629 |
| TRPC3 | ACTIVITY-DEPENDENT RELEASE OF ENDOGENOUS BDNF FROM MOSSY FIBERS EVOKES A TRPC3 CURRENT AND Ca2+ ELEVATIONS IN CA3 PYRAMIDAL NEURONS | J Neurophysiol, May 2010; 103: 2846 - 2856 | shRNA | TR308628 |
| TRPC3 | Ca2+ Waves Initiate Antigen-Stimulated Ca2+ Responses in Mast Cells | J. Immunol., Nov 2009; 183: 6478 - 6488 | shRNA | TR308628 |
| TRPC4 | Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration | FASEB J, Apr 2009; 10.1096/fj.09-131128. | shRNA | TR300814 |
| Trpc5 | Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca(2+) influx | J. Neurochem. | shRNA | TR509727 |
| TRPC5 | Cross-Linking of GM1 Ganglioside by Galectin-1 Mediates Regulatory T Cell Activity Involving TRPC5 Channel Activation: Possible Role in Suppressing Experimental Autoimmune Encephalomyelitis | J. Immunol., Apr 2009; 182: 4036 - 4045. | shRNA | TR308627 |
| TRPC6 | TRPC6 Channels Are Required for Proliferation, Migration and Invasion of Breast Cancer Cell Lines by Modulation of Orai1 and Orai3 Surface Exposure | Cancers (Basel) 2018 | shRNA | TR308626 |
| TRPC6 | Hyperforin/HP-β-Cyclodextrin Enhances Mechanosensitive Ca(2+) Signaling in HaCaT Keratinocytes and in Atopic Skin Ex Vivo Which Accelerates Wound Healing | Biomed Res Int | shRNA | TF308626 |
| TRPC6 | Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes | J. Cell. Sci. | shRNA | TF308626 |
| Trpc6 | HYPERFORIN MODULATES DENDRITIC SPINE MORPHOLOGY IN HIPPOCAMPAL PYRAMIDAL NEURONS BY ACTIVATING Ca 2+ -PERMEABLE TRPC6 CHANNELS | Hippocampus | shRNA | TG711962 |
| TRPC6 | Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration | FASEB J, Apr 2009; 10.1096/fj.09-131128. | shRNA | TR308626 |
| TRPM2 | TRPM2 contributes to LPC-induced intracellular Ca(2+) influx and microglial activation | Biochem. Biophys. Res. Commun | shRNA | TR515108 |
| TRPM2 | The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting | Leukemia July 2014 | shRNA | TG308624 |
| TRPM4 | TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility | PLoS ONE | shRNA | TF504191 |
| TRPM7 | Magnesium-Induced Cell Survival Is Dependent on TRPM7 Expression and Function | Mol. Neurobiol. | shRNA | TR320704 |
| TRPM7 | Cholesterol-induced activation of TRPM7 regulate cell proliferation, migration, and viability of human prostate cells | Biochim. Biophys. Acta. April 2014 | shRNA | TR320704 |
| TRPM7 | Increase in Serum Ca2+/Mg2+ Ratio Promotes Proliferation of Prostate Cancer Cells by Activating TRPM7 Channels | J. Biol. Chem., Jan 2013; 288: 255 - 263. | shRNA | TG516988 |
| TSC22D1 | Transforming Growth Factor-ß–Stimulated Clone-22 Is an Androgen-Regulated Gene That Enhances Apoptosis in Prostate Cancer following Insulin-Like Growth Factor-I Receptor Inhibition | Clin. Cancer Res., Dec 2009; 15: 7634 - 7641 | shRNA | TR300799 |
| TSPAN8 | Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells | Oncotarget | shRNA | TR308597 |
| TSPAN8 | Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts | Oncotarget | shRNA | TR308597 |
| TT200002 | AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells | Biochem. Pharmacol. July 2014 | shRNA | TR30012 |
| TTK | Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores | J. Cell Biol., Jun 2008; 181: 893 - 901 | shRNA | TR320563 |
| TTLL6 | Amyloid-Beta oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin | EMBO J. 2013 Nov 13;32(22):2920-37. | shRNA | TG300748 |
| TUBB3 | ßIII-Tubulin Is a Multifunctional Protein Involved in Drug Sensitivity and Tumorigenesis in Non–Small Cell Lung Cancer | Cancer Res., Jun 2010; 70: 4995 - 5003 | shRNA | TR308568 |
| TULP1 | Tubby-like protein 1 (Tulp1) is a target of microRNA-134 and is down-regulated in experimental epilepsy | Int J Physiol Pathophysiol Pharmacol | shRNA | TR308561 |
| TWIST1 | Overcoming acquired resistance of gefitinib in lung cancer cells without T790M by AZD9291 or Twist1 knockdown in vitro and in vivo | Arch. Toxicol. | shRNA | TF308556 |
| TWIST1 | A83-01 inhibits TGF-β-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells | Breast Cancer Res. Treat | shRNA | TF308556 |
| Txndc5 | Endoplasmic Reticulum Protein ERp46 in Renal Cell Carcinoma | PLoS ONE | shRNA | TG505718 |
| Txnip | Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury | FJan000Research, Jan 2014. | shRNA | TG503152 |
| TXNRD1 | Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells | Free Radic. Biol. Med. | shRNA | TR300712 |
| Ube2e1 | Regulation of canonical Wnt signalling by the ciliopathy protein MKS1 and the E2 ubiquitin-conjugating enzyme UBE2E1 | eLife | shRNA | TR502364 |
| UBE2I | Modulation of host cell SUMOylation facilitates efficient development of Plasmodium berghei and Toxoplasma gondii | Cell. Microbiol | shRNA | TG300697 |
| UBE3A | Interaction of HPV E6 oncoproteins with specific proteasomal subunits | Virology. 2013 Nov;446(1-2):389-96. doi: 10.1016 | shRNA | TG308522 |
| Ube3a | Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome | PLoS Biology | shRNA | TL502369 |
| UBE4B | Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription | PLoS Biol. | shRNA | TF308519 |
| UBE4B | Mitochondrial damage and cholesterol storage in human hepatocellular carcinoma cells with silencing of UBIAD1 gene expression | Molecular Genetics and Metabolism Reports | shRNA | TF308519 |
| UBIAD1 | Mitochondrial damage and cholesterol storage in human hepatocellular carcinoma cells with silencing of UBIAD1 gene expression | Molecular Genetics and Metabolism Reports | shRNA | TF308518 |
| UBR1 | Phosphorylation Impacts N-End Rule Degradation of the Proteolytically Activated Form of BMX Kinase | JBC | shRNA | TG300681 |
| UBR2 | Phosphorylation Impacts N-End Rule Degradation of the Proteolytically Activated Form of BMX Kinase | JBC | shRNA | TF300680 |
| UBXN4 | Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets | Mol. Biol. Cell, Mar 2012; 23: 800 - 810. | shRNA | TR308513 |
| UCHL1 | NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's Disease | Hum. Mol. Genet. | shRNA | TF710038 |
| UCHL1 | Expression and Functional Studies of Ubiquitin C-Terminal Hydrolase L1 Regulated Genes | PLoS ONE 4(8): e6764 (2009) | shRNA | TR316775 |
| UGDH | Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential | Horm Cancer | shRNA | TG308504 |
| UGT8 | Microbubble-based enhancement of radiation effect: Role of cell membrane ceramide metabolism | PLoS ONE | shRNA | TG308493 |
| UHMK1 | Genome-wide association study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene | Bone | shRNA | TR320754 |
| UHRF1 | Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus | J. Clin. Invest. | shRNA | TG308492 |
| UNC13B | CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis | Mol. Biol. Cell Dec 2013. | shRNA | TG710861 |
| Unc93b1 | Antioxidative properties of paraoxonase 2 in intestinal epithelial cells | Am J Physiol Gastrointest Liver Physiol, Sep 2012; 303: G623 - G634. | shRNA | TR515293 |
| UPF1 | UPF1 silenced cellular model systems for screening of read-through agents active on β039 thalassemia point mutation | BMC Biotechnol. | shRNA | TR308482 |
| UPF1 | Modulation of nonsense mediated decay by rapamycin | Nucleic Acids Res. | shRNA | TR308482 |
| UPF1 | A luciferase reporter assay to investigate the differential selenium-dependent stability of selenoprotein mRNAs. | The Journal of nutritional biochemistry | shRNA | TR308482 |
| USP17L2 | The Deubiquitinating Enzyme USP17 Is Highly Expressed in Tumor Biopsies, Is Cell Cycle Regulated, and Is Required for G1-S Progression | Cancer Res., Apr 2010; 70: 3329 - 3339 | shRNA | TR307933 |
| USP17L9P | The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility | Nature Communications 2, 259 (29 March 2011) doi:10.1038/ncomms1243 Article | shRNA | TR321147 |
| USP17L9P | The Deubiquitinating Enzyme USP17 Blocks N-Ras Membrane Trafficking and Activation but Leaves K-Ras Unaffected | J. Biol. Chem., Apr 2010; 285: 12028 - 12036 | shRNA | TR321147 |
| USP19 | USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer | OncoTargets and therapy | shRNA | TR308463 |
| Usp21 | Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions | Mol. Biol. Cell, Mar 2012; 23: 1095 - 1103. | shRNA | TR708469 |
| USP4 | Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease | Hepatology | shRNA | TG502380 |
| USP7 | Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation | The Journal of Biological Chemistry | shRNA | TL308454 |
| USP7 | USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway | Proc Natl Acad Sci U S A | shRNA | TF308454 |
| USP7 | HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation | Nucleic Acids Res. April 2014 | shRNA | TR308454 |
| USP8 | USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-dependent Protein Levels | J. Neurosci. | shRNA | TG705081 |
| USP9X | TGFβ-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Maintenance | SSRN Journal | shRNA | TF510959 |
| USP9X | TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance | Cell Rep | shRNA | TF510959 |
| UXT | Depletion of UXT, a novel TSG101 interaction protein, leads to enhanced CEP55 attenuation through lysosome degradation | Biochemical and biophysical research communications | shRNA | TF308443 |
| VAMP2 | The SNARE Proteins SNAP25 and Synaptobrevin Are Involved in Endocytosis at Hippocampal Synapses | J. Neurosci., May 2013; 33: 9169 - 9175. | shRNA | TF709295 |
| VAMP3 | The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling TCRs to the immune synapse | J. Cell. Sci. | shRNA | TR308442 |
| VAMP3 | The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling TCRs to the immune synapse | J. Cell. Sci. | shRNA | TR515358 |
| VAMP3 | Regulated delivery of molecular cargo to invasive tumour-derived microvesicles | Nat Commun | shRNA | TF308442 |
| various knockdown plasmids | NF-B regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexes | Nucleic Acids Res., Jan 2012; 40: 181 - 195. | shRNA | |
| Vash1 | Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. | Science (New York, N.Y.) | shRNA | TL511800 |
| Vash2 | Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. | Science (New York, N.Y.) | shRNA | TL506751 |
| Vav2 | Transcription factor CUX1 is required for intestinal epithelial wound healing and targets the VAV2-RAC1 Signalling complex. | Biochimica et biophysica acta. Molecular cell research | shRNA | TL705141 |
| VCAN | Versican regulates metastasis of epithelial ovarian carcinoma cells and spheroids | J Ovarian Res July 2014 | shRNA | TG313695 |
| Vdr | The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo | The Journal of Physiology | shRNA | TL709870 |
| VDR | RNAi-mediated knockdown of VDR surprisingly suppresses cell growth in Jurkat T and U87-MG cells | Heliyon | shRNA | TG320568 |
| VDR | Vitamin D deficiency in rats causes cardiac dysfunction by inducing myocardial insulin resistance | Mol Nutr Food Res | shRNA | TG513148 |
| VDR | Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis | Gut July 2014 | shRNA | TG320568 |
| Vegfa | Fluid Flow-induced Soluble Vascular Endothelial Growth Factor Isoforms Regulate Actin Adaptation in Osteoblasts | J. Biol. Chem., Oct 2010; 285: 30931 - 30941 | shRNA | TR510369 |
| VENTX | VentX trans-Activates p53 and p16ink4a to Regulate Cellular Senescence | J. Biol. Chem., Apr 2011; 286: 12693 - 12701 | shRNA | |
| VENTX | VentX, a Novel Lymphoid-Enhancing Factor/T-Cell Factor–Associated Transcription Repressor, Is a Putative Tumor Suppressor | Cancer Res., Jan 2010; 70: 202 - 211 | shRNA | TR317112 |
| VHL | Oncotropic H-1 parvovirus infection degrades HIF-1a protein in human pancreatic cancer cells independently of VHL and RACK1 | Int. J. Oncol. | shRNA | TR300577 |
| VPS13A | A conserved function in phosphatidylinositol metabolism for Mammalian vps13 family proteins | PLoS ONE | shRNA | TF704233 |
| Vps35 | Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer’s disease | Neuron | shRNA | TL503494 |
| WDR5 | TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis | Cancer Res. | shRNA | TG300500 |
| WDR5 | TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis | Cancer Res. | shRNA | TG513026 |
| WDR5 | WDR5 high expression and its effect on tumorigenesis in leukemia | Oncotarget | shRNA | TG300500 |
| WDR82 | Bone morphogenetic protein 4 reduces global H3K4me3 to inhibit proliferation and promote differentiation of human neural stem cells | bioRxiv | shRNA | TG301034 |
| WEE1 | Whole-Genome Expression Microarray Combined with Machine Learning to Identify Prognostic Biomarkers for High-Grade Glioma | J. Mol. Neurosci. | shRNA | TF320571 |
| WFDC2 | Human Epididymis Secretory Protein 4 (HE4) Compromises Cytotoxic Mononuclear Cells via Inducing Dual Specificity Phosphatase 6 | Front Pharmacol | shRNA | TR318721 |
| WFDC2 | HE4 sabotages cytotoxic mononuclear cells via inducing dual specificity phosphatase 6 secretion | Gynecologic Oncology | shRNA | TR318721 |
| WFDC2 | HE4 suppresses the expression of osteopontin in mononuclear cells and compromises their cytotoxicity against ovarian cancer cells | Clin. Exp. Immunol. | shRNA | TR318721 |
| WIF1 | Triptolide inhibits Wnt signaling in NSCLC through upregulation of multiple Wnt inhibitory factors via epigenetic modifications to Histone H3 | Int. J. Cancer | shRNA | TG513512 |
| Wnk1 | WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. | Science signaling | shRNA | TL712155 |
| WNK3 | With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume | Am J Physiol Cell Physiol, Nov 2011; 301: C1150 - C1160. | shRNA | TR320730 |
| WNT3A | Triptolide inhibits Wnt signaling in NSCLC through upregulation of multiple Wnt inhibitory factors via epigenetic modifications to Histone H3 | Int. J. Cancer | shRNA | TG300447 |
| Wnt3a | Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/ß-catenin pathway | Neuro Oncology, Jul 2013; 10.1093/neuonc/not104. | shRNA | TG300447 |
| WNT4 | Context dependent non canonical WNT signaling mediates activation of fibroblasts by transforming growth factor-ß | Exp. Cell Res. | shRNA | TG300446 |
| WNT5A | Activation of Wnt5A signaling is required for CXC chemokine ligand 12–mediated T-cell migration | Blood, Aug 2009; 114: 1366 - 1373 | shRNA | TR320572 |
| WNT5A | Activation of Wnt5A signaling is required for CXCL12-mediated T-cell migration | Blood, Jun 2009; 10.1182/blood-2008-08-175869 | shRNA | TR320572 |
| WNT5B | Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras–Mutated Colorectal Cancer | Mol. Cancer Ther., Dec 2010; 9: 3351 - 3362 | shRNA | TR300445 |
| WNT6 | WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma | Theranostics | shRNA | TR308360 |
| WRN | CDK1 phosphorylates WRN at collapsed replication forks | Nat Commun | shRNA | TR308355 |
| WRN | Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress | Nucleic Acids Res. | shRNA | TF308355 |
| WRNIP1 | Checkpoint Defects Elicit a WRNIP1-Mediated Response to Counteract R-Loop-Associated Genomic Instability | Cancers (Basel) 2020 | shRNA | TR300444 |
| WRNIP1 | Checkpoint defects require WRNIP1 to counteract R-loop-associated genomic instability | bioRxiv | shRNA | TR300444 |
| WT1 | Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis | FASEB J. | shRNA | TG300442 |
| Wwp2 | DIDO as a Switchboard that Regulates Self-Renewal and Differentiation in Embryonic Stem Cells | Stem Cell Reports | shRNA | TG516592 |
| WWTR1 | Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in the muscle injury model | Mol. Cell. Biol., Feb 2014. | shRNA | TF505533 |
| XIAP | MicroRNA-212 inhibits the proliferation, migration and invasion of renal cell carcinoma by targeting X-linked inhibitor of apoptosis protein (XIAP) | Oncotarget | shRNA | TG314473 |
| XKR5 | XK-related protein 5 (XKR5) is a novel negative regulator of KIT/D816V-mediated transformation | Oncogenesis | shRNA | TG300427 |
| XPA | Downregulated XPA promotes carcinogenesis of bladder cancer via impairment of DNA repair | Tumour Biol | shRNA | TR308346 |
| XPC | The Xpc gene markedly affects cell survival in mouse bone marrow | Mutagenesis, Jul 2009; 24: 309 - 316. | shRNA | TR308345 |
| XRCC3 | WRN controls formation of extrachromosomal telomeric circles and is required for TRF2B-mediated telomere shortening | Mol. Cell. Biol., Mar 2008; 28: 1892 - 1904. | shRNA | TR510156 |
| XRCC5 | Dual Functions of the Homeoprotein DLX4 in Modulating Responsiveness of Tumor Cells to Topoisomerase II-Targeting Drugs | Cancer Res., Jan 2013; 73: 1000 - 1010. | shRNA | TG300421 |
| YAP1 | Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway | Biosci. Rep. | shRNA | TR308332 |
| YAP1 | YAP1 plays a key role of the conversion of normal fibroblasts into cancer-associated fibroblasts that contribute to prostate cancer progression | J. Exp. Clin. Cancer Res. | shRNA | TG502437 |
| YBX1 | Silencing Y-box binding protein-1 inhibits triple-negative breast cancer cell invasiveness via regulation of MMP1 and beta-catenin expression | Cancer Lett. | shRNA | TG308329 |
| YWHAB | Infection of Prions and Treatment of PrP106-126 Alter the Endogenous Status of Protein 14-3-3 and Trigger the Mitochondrial Apoptosis Possibly via Activating Bax Pathway | Mol Neurobiol. 2013 Oct 18 | shRNA | TG300398 |
| Yy1 | An integrated transcriptomics-guided genome-wide promoter analysis and next-generation proteomics approach to mine factor(s) regulating cellular differentiation | DNA Res | shRNA | TR713377 |
| ZBTB10 | MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells | Endocrinology, Jun 2010; 151: 2462 - 2473 | shRNA | TR300388 |
| Zbtb16 | Striatal ZBTB16 Is Associated With Cognitive Deficits in Alzheimer Disease Mice | International Neurourology Journal | shRNA | TL507125 |
| ZDHHC18 | DHHC protein family targets different subsets of glioma stem cells in specific niches | J. Exp. Clin. Cancer Res. | shRNA | TF307371 |
| Zdhhc3 | Palmitoylation-dependent control of JAK1 kinase signaling governs responses to neuropoietic cytokines and survival in DRG neurons | The Journal of Biological Chemistry | shRNA | TL703601 |
| Zdhhc3 | Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a | Nat Commun | shRNA | TG504254 |
| ZDHHC8 | Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome | Cereb. Cortex | shRNA | TF308290 |
| Zeb1 | Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2 | Cellular and Molecular Gastroenterology and Hepatology | shRNA | TL513177 |
| ZEB1 | CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells | International journal of molecular sciences | shRNA | TR301174 |
| Zeb1 | CXCR2+ MDSCs promote breast cancer progression by inducing EMT and activated T cell exhaustion | Oncotarget | shRNA | TG513177 |
| ZEB1 | Ginkgolide B Inhibits Human Bladder Cancer Cell Migration and Invasion Through MicroRNA-223-3p | Cell. Physiol. Biochem. | shRNA | TR301174 |
| ZEB2 | miR-637 Prevents Glioblastoma Progression by Interrupting ZEB2/WNT/β-catenin Cascades. | Cellular and molecular neurobiology | shRNA | TG308288 |
| ZEB2 | miR-637 prevents glioblastoma progression by interrupting ZEB2/WNT/β-catenin cascades | Research Square | shRNA | TG308288 |
| Zfp423 | Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation | Molecular and Cellular Biology | shRNA | TL711983 |
| Zfp521 | Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch | Molecular and Cellular Biology | shRNA | TL705963 |
| Zfp521 | Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch | Mol. Cell. Biol. | shRNA | TG506694 |
| Zfpm2 | ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism | J. Clin. Invest. April 2014 | shRNA | TG512097 |
| ZNF567 | RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy | Autophagy | shRNA | TG300130 |
| ZNF567 | RIP1 Kinase Is an Oncogenic Driver in Melanoma | Cancer Res. | shRNA | TG300130 |
| ZSCAN4 | ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype | Oncogene | shRNA | TF300013 |
| ZSCAN5A | A Modified Adenovirus Vector-Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target | Transl Oncol | shRNA | TR300012 |
| ZSCAN5A | The Transcriptional Activity of Osterix Requires the Recruitment of Sp1 to the Osteocalcin Proximal Promoter | Bone | shRNA | TR300012 |
